Research Projects

Esperion ETC 1002 Study Nov 1, 2016 - Mar 31, 2019

PIONEER5: Efficacy and safety of oral semaglutide versus placebo in subjects with type 2 diabetes and moderate renal impairment Nov 1, 2016 - Oct 31, 2019
Primary objective:
To compare the effect of once-daily dosing of 14 mg oral semaglutide versus placebo, both in combination with metformin and/or sulfonylurea, basal insulin alone or metformin in combination with basal insulin on glycaemic control i... Read More about PIONEER5: Efficacy and safety of oral semaglutide versus placebo in subjects with type 2 diabetes and moderate renal impairment.

AX-8 Clinical Research Collaboration Jun 1, 2016 - May 31, 2018
Primary:
Study the efficacy of compound AX-8 in suppressing cough and upper airway symptoms in subjects with cough hypersensitivity syndrome.

Secondary:
Study the safety of compound AX-8.

TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research Sep 1, 2017 - Dec 31, 2026
The death rate is higher in Yorkshire than the rest of England resulting in about 200 extra deaths each year of which more than half are in Hull. There are other significant cancer outcome inequalities between different groups; for example poorer pe... Read More about TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research.

Development and application of a multi-scale computational model of sarcoidosis to predict therapeutic approaches for non-self-resolving disease Jun 30, 2017 - Aug 31, 2020
An in silico computational model of sarcoidosis

A Double-blind, Randomized, Parallel-group, Placebo-controlled Study of MLE4901 for the Treatment of Polycystic Ovary Syndrome (PCOS) Jan 11, 2017 - Jan 10, 2018

BREATHE: Breathlessness RElief AT HomE Apr 1, 2019 - Oct 31, 2021
A feasibility study to address this RQ:
Does a paramedic-administered short non-pharmacological complex breathlessness intervention improve breathlessness and reduce conveyance to ED for people with breathlessness crisis compared with usual practice... Read More about BREATHE: Breathlessness RElief AT HomE.

VOLCANO-2: A double-blind, placebo controlled study of the efficacy and safety of three doses of Orvepitant in subjects with chronic refractory cough Aug 1, 2017 - Dec 31, 2019

Liberates: Improving glucose control in patients with diabetes following myocardial infarction: The role of a novel glycaemic monitoring strategy Aug 1, 2017 - Jul 31, 2020

IVF Study 1: Does Insulin or Endocrine Disruptor levels affect fertility? Jan 1, 2014 - Dec 31, 2018

IVF Study 2: Does Insulin or Endocrine Disruptor levels affect fertility? Jan 1, 2014 - Dec 31, 2018

Trial net CRN funding Jan 1, 2016 - Dec 31, 2018

A study of the incorporation and release of tissue factor as cancer cell-derived microparticles. Aug 1, 2014 - Jul 31, 2017

Lavolta - A phase III, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of May 18, 2014 - Jul 31, 2017

The MID (Multi-Modal Intervention Diabetes) - Frail Study Jun 1, 2015 - Apr 30, 2018

Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature? Jul 1, 2015 - Jun 30, 2020
The study aims to demonstrate the indirect effect of Apixaban on suppressing the release of pro-inflammatory, pro-coagulant tissue factor-containing microvesicles, by inhibiting factor Xa and preventing the activation of PAR2. The study also demonstr... Read More about Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature?.

OSPREY: An Observational Study of the Phenotype and pRescribing in East Yorkshire and its relevance to the introduction of new prescribing guidelines for airways disease. Oct 1, 2016 - Dec 31, 2018

Orbit-4: A multi-centre, randomised, double-blind, placebo-controlled study to evaluate the safety and efficacy of Pulmaquin in the management of chronic lung infections with pseudomonas aeruginosa in subjects with non-cystic fibrosis bronchiectasis, including 28 Oct 31, 2014 - Jul 31, 2018

TUF: The Utility of FeNo in the differential diagnosis of chronic cough Nov 2, 2015 - Jun 1, 2018