Modelling Antifouling compounds of Macroalgal Holobionts in Current and Future pH Conditions (2022)
Journal Article
Hardege, J. D., Roggatz, C. C., & Saha, M. (2022). Modelling Antifouling compounds of Macroalgal Holobionts in Current and Future pH Conditions. Journal of Chemical Ecology, https://doi.org/10.1007/s10886-021-01340-4

Marine macroalgae are important ecosystem engineers in marine coastal habitats. Macroalgae can be negatively impacted through excessive colonization by harmful bacteria, fungi, microalgae, and macro-colonisers and thus employ a range of chemical comp... Read More about Modelling Antifouling compounds of Macroalgal Holobionts in Current and Future pH Conditions.

Behavioural stress propagation in benthic invertebrates caused by acute pH drop-induced metabolites (2021)
Journal Article
Feugere, L., Angell, L., Fagents, J., Nightingale, R., Rowland, K., Skinner, S., …Wollenberg Valero, K. C. (2021). Behavioural stress propagation in benthic invertebrates caused by acute pH drop-induced metabolites. Frontiers in Marine Science, 8, Article 773870. https://doi.org/10.3389/fmars.2021.773870

Studies on pH stress in marine animals typically focus on direct or species-specific aspects. We here test the hypothesis that a drop to pH = 7.6 indirectly affects the intra- and interspecific interactions of benthic invertebrates by means of chemic... Read More about Behavioural stress propagation in benthic invertebrates caused by acute pH drop-induced metabolites.

Uridine-5'-tri-phosphate is a candidate component of the soluble sex pheromone bouquet in a marine shrimp, Lysmata wurdemanni (2020)
Journal Article
Zhang, D., Liu, X., Harley, M. A., & Hardege, J. D. (2020). Uridine-5'-tri-phosphate is a candidate component of the soluble sex pheromone bouquet in a marine shrimp, Lysmata wurdemanni. Marine ecology progress series, 640, 139-146. https://doi.org/10.3354/meps13294

Characterisation of distance sex pheromones in decapods is challenging, although great efforts have been made in this field in the past 50 yr. In a previous study, we identified a component of the distance (soluble) sex pheromone bouquet of the peppe... Read More about Uridine-5'-tri-phosphate is a candidate component of the soluble sex pheromone bouquet in a marine shrimp, Lysmata wurdemanni.

Free-sustaining three-dimensional S235 steel-based porous electrocatalyst for highly efficient and durable oxygen evolution (2018)
Journal Article
Han, W., Kuepper, K., Hou, P., Akram, W., Eickmeier, H., Hardege, J., …Schäfer, H. (2018). Free-sustaining three-dimensional S235 steel-based porous electrocatalyst for highly efficient and durable oxygen evolution. ChemSusChem, 11(20), 3661-3671. https://doi.org/10.1002/cssc.201801351

A novel oxygen evolution reaction (OER) catalyst (3D S235-P steel) based on steel S235 substrate has been successfully prepared via a facile one-step surface modification. The standard Carbon Manganese steel was phosphorizated superficially leading t... Read More about Free-sustaining three-dimensional S235 steel-based porous electrocatalyst for highly efficient and durable oxygen evolution.

Pheromone (2018)
Book Chapter
Vaglio, S., Bartels-Hardege, H., & Hardege, J. (2018). Pheromone. In Encyclopedia of Animal Cognition and Behavior (1-11). Cham: Springer Publishing Company. https://doi.org/10.1007/978-3-319-47829-6_457-1

Target gene expression studies on Platynereis dumerilii and Platynereis cfr massiliensis at the shallow CO2 vents off Ischia, Italy (2017)
Journal Article
Wäge, J., Rotchell, J. M., Gambi, M., & Hardege, J. D. (2018). Target gene expression studies on Platynereis dumerilii and Platynereis cfr massiliensis at the shallow CO2 vents off Ischia, Italy. Estuarine, coastal and shelf science, 207, 351-358. https://doi.org/10.1016/j.ecss.2017.11.012

© 2017 Elsevier Ltd Many studies predict negative effects of ocean acidification on marine organisms, potentially leading to loss of biodiversity and ecosystem function. Research on species inhabiting naturally high pCO2 environments, such as volcani... Read More about Target gene expression studies on Platynereis dumerilii and Platynereis cfr massiliensis at the shallow CO2 vents off Ischia, Italy.

The sibling polychaetes Platynereis dumerilii and Platynereis massiliensis in the Mediterranean Sea: are phylogeographic patterns related to exposure to ocean acidification? (2017)
Journal Article
Wäge, J., Valvassori, G., Hardege, J. D., Schulze, A., & Gambi, M. C. (2017). The sibling polychaetes Platynereis dumerilii and Platynereis massiliensis in the Mediterranean Sea: are phylogeographic patterns related to exposure to ocean acidification?. Marine Biology, 164(10), Article 199. https://doi.org/10.1007/s00227-017-3222-x

High pCO2 environments, such as volcanic carbon dioxide (CO2) vents, which mimic predicted near-future scenarios of ocean acidification (OA), offer an opportunity to examine effects of low pH conditions on marine biodiversity and adaptation/acclimati... Read More about The sibling polychaetes Platynereis dumerilii and Platynereis massiliensis in the Mediterranean Sea: are phylogeographic patterns related to exposure to ocean acidification?.

Electro-oxidation of Ni42 steel: A highly active bifunctional electrocatalyst (2016)
Journal Article
Schäfer, H., Chevrier, D. M., Zhang, P., Stangl, J., Müller-Buschbaum, K., Hardege, J. D., …Schmidt, M. (2016). Electro-oxidation of Ni42 steel: A highly active bifunctional electrocatalyst. Advanced Functional Materials, 26(35), 6402-6417. https://doi.org/10.1002/adfm.201601581

Janus type water‐splitting catalysts have attracted highest attention as a tool of choice for solar to fuel conversion. AISI Ni42 steel is upon harsh anodization converted into a bifunctional electrocatalyst. Oxygen evolution reaction (OER) and hydro... Read More about Electro-oxidation of Ni42 steel: A highly active bifunctional electrocatalyst.

Seizure control by decanoic acid through direct AMPA receptor inhibition (2015)
Journal Article
Chang, P., Augustin, K., Boddum, K., Williams, S., Sun, M., Terschak, J. A., …Williams, R. S. (2016). Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain, 139(2), 431-443. https://doi.org/10.1093/brain/awv325

The medium chain triglyceride ketogenic diet is an established treatment for drug-resistant epilepsy that increases plasma levels of decanoic acid and ketones. Recently, decanoic acid has been shown to provide seizure control in vivo, yet its mechani... Read More about Seizure control by decanoic acid through direct AMPA receptor inhibition.

Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii (2015)
Journal Article
Wäge, J., Lerebours, A., Hardege, J. D., & Rotchell, J. M. (2016). Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii. Ecotoxicology and environmental safety, 124(February), 105-110. https://doi.org/10.1016/j.ecoenv.2015.10.008

© 2015 Elsevier Inc. Fossil fuel emissions and changes in net land use lead to an increase in atmospheric CO 2 concentration and a subsequent decrease of ocean pH. Noticeable effects on organisms' calcification rate, shell structure and energy metabo... Read More about Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii.

Oxidized mild steel S235: an efficient anode for the electrocatalytically initiated water-splitting (2015)
Journal Article
Schäfer, H., Küpper, K., Wollschläger, J., Kashaev, N., Hardege, J., Walder, L., …Dorn, F. (2015). Oxidized mild steel S235: an efficient anode for the electrocatalytically initiated water-splitting. ChemSusChem, 8(18), 3099-3110. https://doi.org/10.1002/cssc.201500666

The surface of steel S235 was oxidized by Cl₂ gas and checked for its electrocatalytic efficiency regarding oxygen formation in aqueous solution. If exposed to humid Cl₂ gas for 110 min, steel S235 became an electrocatalyst that exhibits an overpoten... Read More about Oxidized mild steel S235: an efficient anode for the electrocatalytically initiated water-splitting.

Effects of low seawater pH on the marine polychaete Platynereis dumerilii (2015)
Journal Article
Wäge, J., Hardege, J. D., Larsson, T. A., Simakov, O., Chapman, E. C., Arendt, D., & Rotchell, J. M. (2015). Effects of low seawater pH on the marine polychaete Platynereis dumerilii. Marine pollution bulletin, 95(1), 166-172. https://doi.org/10.1016/j.marpolbul.2015.04.027

An important priority for any organism is to maintain internal cellular homeostasis including acidbase balance. Yet, the molecular level impacts of changing environmental conditions, such as low pH, remain uncharacterised. Herein, we isolate partial... Read More about Effects of low seawater pH on the marine polychaete Platynereis dumerilii.

Identification of a female sex pheromone in Carcinus maenas (2011)
Journal Article
Hardege, J. D., Bartels-Hardege, H. D., Fletcher, N., Terschak, J. A., Harley, M., Smith, M. A., …Bublitz, R. (2011). Identification of a female sex pheromone in Carcinus maenas. Marine ecology progress series, 436, 177-189. https://doi.org/10.3354/meps09226

Despite major progress in our understanding of animal signaling systems, the identification of chemical signals in aquatic organisms is still in its infancy. Exemplary for this is the lack of structural knowledge of crustacean sex pheromones despite... Read More about Identification of a female sex pheromone in Carcinus maenas.

Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification (2011)
Journal Article
Hardege, J., Rotchell, J., Terschak, J., & Greenway, G. (2011). Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification. Trends in Analytical Chemistry, 30(8), 1320-1326. https://doi.org/10.1016/j.trac.2011.07.004

Changing ocean-carbonate chemistry caused by oceanic uptake of anthropogenic atmospheric carbon dioxide leads to the formation of carbonic acid, thus lowering the pH of the sea with predictions of a decrease from current levels at 8.15 to 7.82 by the... Read More about Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification.

Simultaneously hermaphroditic shrimp use lipophilic cuticular hydrocarbons as contact sex pheromones (2011)
Journal Article
Hardege, J. D., Harley, M. A., Lin, J., Terschak, J. A., & Zhang, D. (2011). Simultaneously hermaphroditic shrimp use lipophilic cuticular hydrocarbons as contact sex pheromones. PLoS ONE, 6(4), e17720. https://doi.org/10.1371/journal.pone.0017720

Successful mating is essentially a consequence of making the right choices at the correct time. Animals use specific strategies to gain information about a potential mate, which is then applied to decision-making processes. Amongst the many informati... Read More about Simultaneously hermaphroditic shrimp use lipophilic cuticular hydrocarbons as contact sex pheromones.

The fecal odor of sick hedgehogs (Erinaceus europaeus) mediates olfactory attraction of the tick Ixodes hexagonus (2011)
Journal Article
Bunnell, T., Hanisch, K., Hardege, J. D., & Breithaupt, T. (2011). The fecal odor of sick hedgehogs (Erinaceus europaeus) mediates olfactory attraction of the tick Ixodes hexagonus. Journal of Chemical Ecology, 37(4), 340-347. https://doi.org/10.1007/s10886-011-9936-1

Parasite loads of animals vary among individuals, but the underlying mechanisms have not been fully identified. Here, we investigated whether health status of hedgehogs (Erinaceus europaeus) is correlated with tick burden, and whether chemical cues l... Read More about The fecal odor of sick hedgehogs (Erinaceus europaeus) mediates olfactory attraction of the tick Ixodes hexagonus.

New compounds, sexual differences, and age-related variations in the femoral gland secretions of the lacertid lizard Acanthodactylus boskianus (2011)
Journal Article
Khannoon, E. R., Flachsbarth, B., El-Gendy, A., Mazik, K., Hardege, J. D., & Schulz, S. (2011). New compounds, sexual differences, and age-related variations in the femoral gland secretions of the lacertid lizard Acanthodactylus boskianus. Biochemical Systematics and Ecology, 39(2), 95-101. https://doi.org/10.1016/j.bse.2011.01.008

Integumental gland secretions in lizards have been postulated to play a role as semiochemicals, but few studies have analysed the chemical nature of the gland secretions used in communication. We analysed the femoral gland secretions of Acanthodactyl... Read More about New compounds, sexual differences, and age-related variations in the femoral gland secretions of the lacertid lizard Acanthodactylus boskianus.

Biological responses to contaminants in the Humber Estuary: disentangling complex relationships (2011)
Journal Article
García-Alonso, J., Greenway, G., Munshi, A., Gómez, J., Mazik, K., Knight, A. W., …Elliott, M. (2011). Biological responses to contaminants in the Humber Estuary: disentangling complex relationships. Marine environmental research, 71(4), 295-303. https://doi.org/10.1016/j.marenvres.2011.02.004

Due to the ecological importance of estuaries, it is necessary to understand the biological effects that potentially toxic contaminants induce in bioindicator species. A key aspect is whether effects at lower levels of biological organisation transfe... Read More about Biological responses to contaminants in the Humber Estuary: disentangling complex relationships.

Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis) (2011)
Journal Article
Velez, Z., Hubbard, P. C., Hardege, J. D., Welham, K. J., Barata, E. N., & Canário, A. V. M. (2011). Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis). Aquaculture, 314(1-4), 153-158. https://doi.org/10.1016/j.aquaculture.2011.01.025

Nocturnal animals often rely heavily on olfactory cues to locate their food. This is especially true for fish whose prey live buried in the substrate. The aim of the current study was to identify non-polar odorants released by the ragworm (Hediste di... Read More about Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis).

Microscreening toxicity system based on living magnetic yeast and gradient chips (2010)
Journal Article
García-Alonso, J., Fakhrullin, R. F., Paunov, V. N., Shen, Z., Hardege, J. D., Pamme, N., …Greenway, G. M. (2011). Microscreening toxicity system based on living magnetic yeast and gradient chips. Analytical and Bioanalytical Chemistry, 400(4), 1009-1013. https://doi.org/10.1007/s00216-010-4241-3

There is an increasing demand for easy and cost-effective methods to screen the toxicological impact of the growing number of chemical mixtures being generated by industry. Such a screening method has been developed using viable, genetically modified... Read More about Microscreening toxicity system based on living magnetic yeast and gradient chips.