A guide to pedagogical research for scientists from a biological sciences background (2022)
Journal Article
Lacey, M. M., & Efthimiou, G. (2022). A guide to pedagogical research for scientists from a biological sciences background. Access Microbiology, 4(8), Article 416. https://doi.org/10.1099/acmi.0.000416

How we teach science and engage with the public, particularly in fast moving subjects such as microbiology, are constantly being reflected upon, improved and innovated. This has led to a significant increase of pedagogy publications by microbiology e... Read More about A guide to pedagogical research for scientists from a biological sciences background.

Enhanced stimulation of antigen-specific immune responses against nucleophosmin 1 mutated acute myeloid leukaemia by an anti-programmed death 1 antibody (2022)
Journal Article
Greiner, J., Goetz, M., Schuler, P. J., Bulach, C., Hofmann, S., Schrezenmeier, H., …Guinn, B. A. (2022). Enhanced stimulation of antigen-specific immune responses against nucleophosmin 1 mutated acute myeloid leukaemia by an anti-programmed death 1 antibody. British journal of haematology, 198(5), 866-874. https://doi.org/10.1111/bjh.18326

Nucleophosmin1 (NPM1) is one of the most commonly mutated genes in AML and is often associated with a favourable prognosis. Immune responses play an increasing role in AML treatment decisions; however, the role of immune checkpoint inhibition is stil... Read More about Enhanced stimulation of antigen-specific immune responses against nucleophosmin 1 mutated acute myeloid leukaemia by an anti-programmed death 1 antibody.

Molecular Mechanisms and Therapies of Myeloid Leukaemia (2022)
Journal Article
Brown, E., & Guinn, B. A. (2022). Molecular Mechanisms and Therapies of Myeloid Leukaemia. International Journal of Molecular Sciences, 23(11), Article 6251. https://doi.org/10.3390/ijms23116251

microRNA expression in acute myeloid leukaemia: New targets for therapy? (2022)
Journal Article
Fletcher, D., Brown, E., Javadala, J., Uysal-Onganer, P., & Guinn, B. (2022). microRNA expression in acute myeloid leukaemia: New targets for therapy?. eJHaem, 3(3), 596-608. https://doi.org/10.1002/jha2.441

Recent studies have shown that short non-coding RNAs, known as microRNAs (miRNAs) and their dysregulation, are implicated in the pathogenesis of acute myeloid leukaemia (AML). This is due to their role in the control of gene expression in a variety o... Read More about microRNA expression in acute myeloid leukaemia: New targets for therapy?.

miRNA expression in acute myeloid leukaemia: new targets for therapy? (2022)
Journal Article
Fletcher, D., Brown, E., Javadala, J., Uysal-Onganer, P., & Guinn, B. (in press). miRNA expression in acute myeloid leukaemia: new targets for therapy?. eJHaem, https://doi.org/10.1002/jha2.441

Recent studies have shown that short non-coding RNAs, known as microRNAs (miRNAs) and their dysregulation, are implicated in the pathogenesis of acute myeloid leukaemia (AML). This is due to their role in the control of gene expression in a variety o... Read More about miRNA expression in acute myeloid leukaemia: new targets for therapy?.

Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis (2022)
Working Paper
Faulkner, E. C., Moverley, A. A., Hart, S. P., & Nikitenko, L. L. Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis

Increasing age is the main risk factor for chronic lung diseases (CLD) including idiopathic pulmonary fibrosis (IPF). Halting or reversing progression of IPF remains an unmet clinical need due to limited knowledge of underlying mechanisms. In particu... Read More about Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis.

Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review (2022)
Journal Article
Butler, H., Saulat, O., & Guinn, B. A. (2022). Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review. Carcinogenesis, 43(3), 183-189. https://doi.org/10.1093/carcin/bgac012

Clear cell ovarian cancer (CCOC) is a rare type of epithelial cancer often resistant to platinum-based chemotherapy. Biomarkers for the diagnosis of CCOC, and targets for immunotherapy, both have the potential to improve outcomes for patients. Our re... Read More about Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review.

Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients (2021)
Journal Article
Greiner, J., Brown, E., Bullinger, L., Hills, R. K., Morris, V., Döhner, H., …Guinn, B. A. (2021). Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients. International Journal of Molecular Sciences, 22(19), Article 10482. https://doi.org/10.3390/ijms221910482

Abstract: Despite recent advances in therapies including immunotherapy, patients with acute myeloid leukaemia (AML) still experience relatively poor survival rates. The Inhibition of Apoptosis (IAP) family member, survivin, also known by its gene and... Read More about Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients.

Can non-invasive biomarkers lead to an earlier diagnosis of Alzheimer’s Disease? (2021)
Journal Article
Bature, F., Pappas, Y., Pang, D., & Guinn, B. A. (2021). Can non-invasive biomarkers lead to an earlier diagnosis of Alzheimer’s Disease?. Current Alzheimer Research, 18(11), 908-913. https://doi.org/10.2174/1567205018666211207094630

Olive Pomace Oil can be Used as an Alternative Carbon Source for Clavulanic Acid Production by Streptomyces clavuligerus (2019)
Journal Article
Young, T., Li, Y., & Efthimiou, G. (2020). Olive Pomace Oil can be Used as an Alternative Carbon Source for Clavulanic Acid Production by Streptomyces clavuligerus. Waste and biomass valorization, 11(8), 3965-3970. https://doi.org/10.1007/s12649-019-00719-5

Clavulanic acid is an important drug, both medically and economically. It is used to combat bacterial resistance to β-lactam antibiotics and is on the World Health Organisation’s List of Essential Medicines in combination with amoxicillin. An olive o... Read More about Olive Pomace Oil can be Used as an Alternative Carbon Source for Clavulanic Acid Production by Streptomyces clavuligerus.

Simultaneous analysis of micro-RNA and DNA for determining the body fluid origin of DNA profiles (2013)
Journal Article
van der Meer, D., Uchimoto, M. L., & Williams, G. (2013). Simultaneous analysis of micro-RNA and DNA for determining the body fluid origin of DNA profiles. Journal of Forensic Sciences, 58(4), 967-971. https://doi.org/10.1111/1556-4029.12160

Micro-RNAs (miRNAs) can be specifically expressed in forensically relevant body fluids such as blood or saliva. The aim of the study was to develop a simultaneous extraction and analysis protocol that allows for the acquisition of a DNA profile and t... Read More about Simultaneous analysis of micro-RNA and DNA for determining the body fluid origin of DNA profiles.