Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk (2020)
Journal Article
Khan, Q. M., Asif, M., Awan, F. R., Khan, Q. . M., Ngamsom, B., & Pamme, N. (2020). Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk. Analyst, 145(22), 7320-7329. https://doi.org/10.1039/d0an01075h

Animal derived milk which is an important part of human diet due to its high nutritional value not only supports humans but also presents a growth environment for pathogenic bacteria. Milk may become contaminated with bacteria through udder infection... Read More about Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk.

The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance (2020)
Journal Article
Satta, G., Witney, A. A., Begum, N., Ortiz Canseco, J., Boa, A. N., & McHugh, T. D. (2020). The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance. Antimicrobial agents and chemotherapy, 64(9), Article e00675-20. https://doi.org/10.1128/AAC.00675-20

Para-aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is not completely understood yet. The main aim of this project was to identify new potential mechanisms of action an... Read More about The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance.

A feasibility study of a leaky waveguide aptasensor for thrombin (2019)
Journal Article
Alamrani, N. A., Greenway, G. M., Pamme, N., Goddard, N. J., & Gupta, R. (2019). A feasibility study of a leaky waveguide aptasensor for thrombin. Analyst, 144(20), 6048-6054. https://doi.org/10.1039/c9an01421g

This proof-of-principle study demonstrates the feasibility of a leaky waveguide (LW) aptasensor, where aptamers were immobilised in a mesoporous chitosan waveguiding film for the detection of thrombin. This work has demonstrated that aptamers immobil... Read More about A feasibility study of a leaky waveguide aptasensor for thrombin.

A method for determining average iron content of ferritin by measuring its optical dispersion (2019)
Journal Article
Gupta, R., Alamrani, N. A., Greenway, G. M., Pamme, N., & Goddard, N. J. (2019). A method for determining average iron content of ferritin by measuring its optical dispersion. Analytical chemistry, 91(11), 7366-7372. https://doi.org/10.1021/acs.analchem.9b01231

© 2019 American Chemical Society. We report a method where the refractive index increments of an iron storage protein, ferritin, and apoferritin (ferritin minus iron) were measured over the wavelength range of 450-678 nm to determine the average iron... Read More about A method for determining average iron content of ferritin by measuring its optical dispersion.

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites (2019)
Journal Article
Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators... Read More about N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals (2018)
Journal Article
Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., …Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry: a European journal, 24(52), 13749-13753. https://doi.org/10.1002/chem.201802395

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclid... Read More about Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals.

On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules (2017)
Journal Article
Alorabi, A. Q., Tarn, M. D., Gómez-Pastora, J., Bringas, E., Ortiz, I., Paunov, V. N., & Pamme, N. (2017). On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules. Lab on a chip, 17(22), 3785-3795. https://doi.org/10.1039/c7lc00918f

Polyelectrolyte (PE) microcapsules for drug delivery are typically fabricated via layer-by-layer (LbL) deposition of PE layers of alternating charge on sacrificial template microparticles, which usually requires multiple incubation and washing steps... Read More about On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules.

Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes (2017)
Journal Article
McConkey, G. A., Bedingfield, P. T., Burrell, D. R., Chambers, N. C., Cunningham, F., Prior, T. J., …Boa, A. N. (2017). Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes. Bioorganic and Medicinal Chemistry Letters, 27(16), 3878-3882. https://doi.org/10.1016/j.bmcl.2017.06.052

Two new tricyclic β-aminoacrylate derivatives (2e and 3e) have been found to be inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with Ki 0.037 and 0.15 μM respectively. 1H and 13C NMR spectroscopic data show that these compo... Read More about Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.

Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples (2016)
Journal Article
Esfahani, M. M. N., Shaw, K. J., Esfahani, M. M., Kemp, C., Tarn, M. D., Melling, L., …Mosley, O. (2016). Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples. Lab on a chip, 16(11), 2108-2115. https://doi.org/10.1039/c6lc00228e

Despite recent advances in microfluidic-based integrated diagnostic systems, the sample introduction interface, especially with regards to large volume samples, has often been neglected. We present a sample introduction interface that allows direct o... Read More about Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples.