Dual-functionalised shellac nanocarriers give a super-boost of the antimicrobial action of berberine (2018)
Journal Article
Al-Obaidy, S. S., Greenway, G. M., & Paunov, V. N. (in press). Dual-functionalised shellac nanocarriers give a super-boost of the antimicrobial action of berberine. Nanoscale advances, https://doi.org/10.1039/c8na00121a

We have developed highly efficient antimicrobial nanocarriers for berberine (BRB) based on shellac nanoparticles (NPs) which were surface-functionalised with a surface active polymer, Poloxamer 407 (P407), and the cationic surfactant octadecyltrimeth... Read More

Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. doi:10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. doi:10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More

Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers (2018)
Journal Article
Al-Awady, M. J., Weldrick, P. J., Hardman, M. J., Greenway, G. M., & Paunov, V. N. (2018). Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers. Materials Chemistry Frontiers, 2(11), 2032-2044. doi:10.1039/c8qm00343b

We have developed and tested a novel functionalised nanocarrier for chlorhexidine (CHX) which provides a very strong enhancement of its antimicrobial action. The nanocarrier was based on lightly-cross-linked acrylate copolymer nanogel particles loade... Read More

Electrochemical measurement of antibody­‐antigen recognition biophysics: thermodynamics and kinetics of human chorionic gonadotropin (hCG) binding to redox-­tagged antibodies (2018)
Journal Article
Partington, L. I., Atkin, S. L., Kilpatrick, E. S., Morris, S. H., Piper, M., Lawrence, N. S., & Wadhawan, J. D. (in press). Electrochemical measurement of antibody­‐antigen recognition biophysics: thermodynamics and kinetics of human chorionic gonadotropin (hCG) binding to redox-­tagged antibodies. Journal of Electroanalytical Chemistry, ISSN 1572-6657

The thermodynamics and kinetics of antigen binding under diffusive conditions to an electrode surface modified with ferrocene-tagged antibodies is studied within this work, and realised experimentally for the case of human chorionic gonadotropin (hGC... Read More

A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain (2018)
Journal Article
Blanke, A., Pinheiro, M., Watson, P. J., Blanke, A., Pinheiro, M., Watson, P. J., & Fagan, M. J. (2018). A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain. Journal of evolutionary biology, 31(5), 665-674. doi:10.1111/jeb.13251

Insect head shapes are remarkably variable but the influences of these changes on biomechanical performance are unclear. Among “basal” winged insects, such as dragonflies, mayflies, earwigs, and stoneflies, some of the most prominent anatomical chang... Read More

New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction (2018)
Journal Article
Pinheiro, M., Dobson, C. A., Perry, D., & Fagan, M. J. (2018). New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction. Bone & joint research, 7(2), (148-156). doi:10.1302/2046-3758.72.bjr-2017-0191.r1. ISSN 2046-3758

Objectives Legg–Calvé–Perthes’ disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed tha... Read More

Enhanced antimicrobial effect of berberine in nanogel carriers with cationic surface functionality (2017)
Journal Article
Al-Awady, M. J., Fauchet, A., Greenway, G. M., & Paunov, V. N. (2017). Enhanced antimicrobial effect of berberine in nanogel carriers with cationic surface functionality. Journal of materials chemistry B, Materials for biology and medicine /, 5(38), 7885-7897. doi:10.1039/c7tb02262j

We report a strong enhancement in the antimicrobial action of berberine encapsulated into polyacrylic acid-based nanogels followed by further surface functionalisation with a cationic polyelectrolyte (PDAC). Due to the highly developed surface area,... Read More

Colloid particle formulations for antimicrobial applications (2017)
Journal Article
Halbus, A. F., Horozov, T. S., & Paunov, V. N. (2017). Colloid particle formulations for antimicrobial applications. Advances in Colloid and Interface Science, 249, 134-148. doi:10.1016/j.cis.2017.05.012

Colloidal particles are being extensively studied in various antimicrobial applications due to their small size to volume ratio and ability to exhibit a wide spectrum of antibacterial, antifungal, antialgal and antiviral action. The present review fo... Read More

Computational biomechanics changes our view on insect head evolution (2017)
Journal Article
Blanke, A., Watson, P. J., Holbrey, R., & Fagan, M. J. (2017). Computational biomechanics changes our view on insect head evolution. Proceedings. the Royal Society. Biological sciences /, 284(1848), doi:10.1098/rspb.2016.2412. ISSN 0962-8452

© 2017 The Author(s) Published by the Royal Society. All rights reserved. Despite large-scale molecular attempts, the relationships of the basal winged insect lineages dragonflies, mayflies and neopterans, are still unresolved. Other data sources, su... Read More