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Computational biomechanics changes our view on insect head evolution (2017)
Journal Article
Blanke, A., Watson, P. J., Holbrey, R., & Fagan, M. J. (2017). Computational biomechanics changes our view on insect head evolution. Proceedings of the Royal Society B: Biological Sciences, 284(1848), Article 20162412. https://doi.org/10.1098/rspb.2016.2412

© 2017 The Author(s) Published by the Royal Society. All rights reserved. Despite large-scale molecular attempts, the relationships of the basal winged insect lineages dragonflies, mayflies and neopterans, are still unresolved. Other data sources, su... Read More about Computational biomechanics changes our view on insect head evolution.

Restoring speech following total removal of the larynx by a learned transformation from sensor data to acoustics (2017)
Journal Article
Gilbert, J. M., Gonzalez, J. A., Cheah, L. A., Ell, S. R., Green, P., Moore, R. K., & Holdsworth, E. (2017). Restoring speech following total removal of the larynx by a learned transformation from sensor data to acoustics. The Journal of the Acoustical Society of America, 141(3), EL307-EL313. https://doi.org/10.1121/1.4978364

Total removal of the larynx may be required to treat laryngeal cancer: speech is lost. This article shows that it may be possible to restore speech by sensing movement of the remaining speech articulators and use machine learning algorithms to derive... Read More about Restoring speech following total removal of the larynx by a learned transformation from sensor data to acoustics.

The effect of boundary constraints on finite element modelling of the human pelvis (2017)
Journal Article
Watson, P., Dostanpor, A., Fagan, M. J., & Dobson, C. A. (2017). The effect of boundary constraints on finite element modelling of the human pelvis. Medical engineering & physics, 43, 48-57. https://doi.org/10.1016/j.medengphy.2017.02.001

The use of finite element analysis (FEA) to investigate the biomechanics of anatomical systems critically relies on the specification of physiologically representative boundary conditions. The biomechanics of the pelvis has been the specific focus of... Read More about The effect of boundary constraints on finite element modelling of the human pelvis.

Form-function relationships in dragonfly mandibles under an evolutionary perspective (2017)
Journal Article
Blanke, A., Schmitz, H., Patera, A., Dutel, H., & Fagan, M. J. (2017). Form-function relationships in dragonfly mandibles under an evolutionary perspective. Journal of the Royal Society interface / the Royal Society, 14(128), Article 20161038. https://doi.org/10.1098/rsif.2016.1038

© 2017 The Author(s). Functional requirements may constrain phenotypic diversification or foster it. For insect mouthparts, the quantification of the relationship between shape and function in an evolutionary framework remained largely unexplored. He... Read More about Form-function relationships in dragonfly mandibles under an evolutionary perspective.

Modelling human skull growth: a validated computational model (2017)
Journal Article
Libby, J., Marghoub, A., Johnson, D., Khonsari, R. H., Fagan, M. J., & Moazen, M. (2017). Modelling human skull growth: a validated computational model. Journal of the Royal Society interface / the Royal Society, 14(130), 20170202. https://doi.org/10.1098/rsif.2017.0202

© 2017 The Author(s) Published by the Royal Society. All rights reserved. During the first year of life, the brain grows rapidly and the neurocranium increases to about 65% of its adult size. Our understanding of the relationship between the biomecha... Read More about Modelling human skull growth: a validated computational model.

Heart sound classification from unsegmented phonocardiograms (2017)
Journal Article
Langley, P., & Murray, A. (2017). Heart sound classification from unsegmented phonocardiograms. Physiological Measurement, 38(8), 1658-1670. https://doi.org/10.1088/1361-6579/aa724c

Objective Most algorithms for automated analysis of phonocardiograms (PCG) require segmentation of the signal into the characteristic heart sounds. The aim was to assess the feasibility for accurate classification of heart sounds on short, unsegmente... Read More about Heart sound classification from unsegmented phonocardiograms.

Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains (2017)
Journal Article
McCormack, S. W., Witzel, U., Watson, P. J., Fagan, M. J., & Gröning, F. (2017). Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains. PLoS ONE, 12(11), e0188707. https://doi.org/10.1371/journal.pone.0188707

Alveolar bone remodelling is vital for the success of dental implants and orthodontic treatments. However, the underlying biomechanical mechanisms, in particular the function of the periodontal ligament (PDL) in bone loading and remodelling, are not... Read More about Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains.

Direct Speech Reconstruction from Articulatory Sensor Data by Machine Learning (2017)
Journal Article
Gonzalez, J. A., Cheah, L. A., Gomez, A. M., Green, P. D., Gilbert, J. M., Ell, S. R., Moore, R. K., & Holdsworth, E. (2017). Direct Speech Reconstruction from Articulatory Sensor Data by Machine Learning. IEEE/ACM transactions on audio, speech, and language processing, 25(12), 2362-2374. https://doi.org/10.1109/TASLP.2017.2757263

© 2014 IEEE. This paper describes a technique that generates speech acoustics from articulator movements. Our motivation is to help people who can no longer speak following laryngectomy, a procedure that is carried out tens of thousands of times per... Read More about Direct Speech Reconstruction from Articulatory Sensor Data by Machine Learning.

New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction (2018)
Journal Article
Pinheiro, M., Dobson, C. A., Perry, D., & Fagan, M. J. (2018). New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction. Bone & joint research, 7(2), 148-156. https://doi.org/10.1302/2046-3758.72.bjr-2017-0191.r1

Objectives Legg–Calvé–Perthes’ disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed th... Read More about New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction.

The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation (2018)
Journal Article
Pinheiro, M. D. S., Dobson, C., Clarke, N. M., & Fagan, M. (2018). The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation. Computer methods in biomechanics and biomedical engineering, 21(2), 194-200. https://doi.org/10.1080/10255842.2018.1437151

© 2018 Informa UK Limited, trading as Taylor & Francis Group Legg-Calvé-Perthes disease (LCP) is one of the most poorly understood diseases in paediatric orthopaedics. One common trait of LCP is the marked morphological difference between healthy a... Read More about The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation.

A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain (2018)
Journal Article
Blanke, A., Pinheiro, M., Watson, P. J., & Fagan, M. J. (2018). A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain. Journal of evolutionary biology, 31(5), 665-674. https://doi.org/10.1111/jeb.13251

Insect head shapes are remarkably variable but the influences of these changes on biomechanical performance are unclear. Among “basal” winged insects, such as dragonflies, mayflies, earwigs, and stoneflies, some of the most prominent anatomical chang... Read More about A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain.

Mechanical adaptation of trabecular bone morphology in the mammalian mandible (2018)
Journal Article
Watson, P. J., Fitton, L. C., Meloro, C., Fagan, M. J., & Gröning, F. (2018). Mechanical adaptation of trabecular bone morphology in the mammalian mandible. Scientific reports, 8(1), Article 7277. https://doi.org/10.1038/s41598-018-25597-0

Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this struct... Read More about Mechanical adaptation of trabecular bone morphology in the mammalian mandible.

Categorisation of Mobile EEG: A Researcher's Perspective (2017)
Journal Article
Bateson, A. D., Baseler, H. A., Paulson, K. S., Ahmed, F., & Asghar, A. U. (2017). Categorisation of Mobile EEG: A Researcher's Perspective. Biomed research international, 2017, 1-15. https://doi.org/10.1155/2017/5496196

© 2017 Anthony D. Bateson et al. Researchers are increasingly attempting to undertake electroencephalography (EEG) recordings in novel environments and contexts outside of the traditional static laboratory setting. The term "mobile EEG," although com... Read More about Categorisation of Mobile EEG: A Researcher's Perspective.

Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density (2018)
Journal Article
Dostanpor, A., Dobson, C. A., & Vanicek, N. (2018). Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density. Gait and Posture, 64, 230-237. https://doi.org/10.1016/j.gaitpost.2018.05.005

Background: The gait patterns of women with low bone mineral density (BMD) or osteoporosis have not been thoroughly explored, and when examined, often studied in relation to falls and kyphosis. Research question: The aim of this study was to investig... Read More about Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density.

Validation of an algorithm to reveal the U wave in atrial fibrillation (2018)
Journal Article
Al-Karadi, M. S., Wilkinson, A. J., Caldwell, J., & Langley, P. (2018). Validation of an algorithm to reveal the U wave in atrial fibrillation. Scientific reports, 8(1), Article 11946. https://doi.org/10.1038/s41598-018-30493-8

Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U... Read More about Validation of an algorithm to reveal the U wave in atrial fibrillation.

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. https://doi.org/10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More about The role of miniaturization in the evolution of the mammalian jaw and middle ear.

An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus) (2018)
Journal Article
Sellés de Lucas, V., Dutel, H., Evans, S. E., Gröning, F., Sharp, A. C., Watson, P. J., & Fagan, M. J. (2018). An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus). Interface, 15(147), Article 20180278. https://doi.org/10.1098/rsif.2018.0278

© 2018 The Author(s). The falx cerebri and the tentorium cerebelli are two projections of the dura mater in the cranial cavity which ossify to varying degrees in some mammalian species. The idea that the ossification of these structures may be necess... Read More about An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus).

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More about Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway.

Characterizing and Modeling Bone Formation during Mouse Calvarial Development (2019)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Ventikos, Y., Fagan, M. J., & Moazen, M. (2019). Characterizing and Modeling Bone Formation during Mouse Calvarial Development. Physical review letters, 122(4), Article 048103. https://doi.org/10.1103/PhysRevLett.122.048103

© 2019 American Physical Society. The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as c... Read More about Characterizing and Modeling Bone Formation during Mouse Calvarial Development.

A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth (2019)
Journal Article
Pinheiro, M., Ma, X., Fagan, M. J., McIntyre, G. T., Lin, P., Sivamurthy, G., & Mossey, P. A. (2019). A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth. Journal of Biological Engineering, 13(1), https://doi.org/10.1186/s13036-019-0171-6

© 2019 The Author(s). Background: Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal planes and... Read More about A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth.