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Welcome to Repository@Hull

The Repository@Hull is intended to be an Open Access showcase for the published research output of the university. Whenever possible, refereed documents accepted for publication, or finished artistic compositions presented in public, will be made available here in full digital format, and hyperlinks to standard published versions will be provided.



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An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner (2008)
Journal Article
Hager, S., Frame, F. M., Collins, A. T., Burns, J. E., & Maitland, N. J. (2008). An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner. Human Gene Therapy, 19(8), 840-850. https://doi.org/10.1089/hum.2007.165

In lentiviral gene delivery systems, transgene expression cassettes are commonly cloned without a polyadenylation signal to prevent disruption of full-length lentiviral genomes on mRNA maturation in producer cells. The lack of the polyadenylation sig... Read More

Prostate cancer stem cells (2008)
Journal Article
Lang, S., Frame, F., & Collins, A. (2009). Prostate cancer stem cells. Journal of Pathology, 217(2), 299-306. https://doi.org/10.1002/path.2478

Despite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone‐refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours orig... Read More

Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells (2010)
Journal Article
Frame, F. M., Hager, S., Pellacani, D., Stower, M. J., Walker, H. F., Burns, J. E., …Maitland, N. J. (2010). Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells. Experimental Cell Research, 316(19), 3161-3171. https://doi.org/10.1016/j.yexcr.2010.08.004

To investigate hierarchy in human prostate epithelial cells, we generated recombinant lentiviruses, infected primary cultures and cell lines, and followed their fate in vitro. The lentiviruses combined constitutive promoters including CMV and β-actin... Read More

Prostate cancer stem cells: do they have a basal or luminal phenotype? (2011)
Journal Article
Maitland, N. J., Frame, F. M., Polson, E. S., Lewis, J. L., & Collins, A. T. (2011). Prostate cancer stem cells: do they have a basal or luminal phenotype?. Hormones and Cancer, 2(1), 47-61. https://doi.org/10.1007/s12672-010-0058-y

The prostate is a luminal secretory tissue whose function is regulated by male sex hormones. Castration produces involution of the prostate to a reversible basal state, and as the majority of prostate cancers also have a luminal phenotype, drug-induc... Read More

Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer (2011)
Journal Article
Pellacani, D., Packer, R. J., Frame, F. M., Oldridge, E. E., Berry, P. A., Labarthe, M., …Maitland, N. J. (2011). Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer. Molecular Cancer, 10(1), https://doi.org/10.1186/1476-4598-10-94

Background Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is sti... Read More

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