Outputs (211)

Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex (2019)
Journal Article
Benelhaj, N. E., Maraveyas, A., Featherby, S., Collier, M. E., Johnson, M. J., & Ettelaie, C. (2019). Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex. Thrombosis Research, 175, 13-20. https://doi.org/10.1016/j.thromres.2019.01.009

Alterations in the endothelial permeability occur in response to the activation of coagulation mechanisms in order to control clot formation. The activation of the protease activated receptors (PAR) can induce signals that regulate such cellular resp... Read More about Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex.

Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study (2019)
Journal Article
Ekström, M., Williams, M., Johnson, M. J., Huang, C., & Currow, D. C. (2019). Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study. Journal of pain and symptom management, 57(4), 715-723.e5. https://doi.org/10.1016/j.jpainsymman.2019.01.001

Context: Chronic breathlessness is a cardinal symptom in cardiopulmonary disease where both overall intensity or severity (S) and unpleasantness (U) are commonly quantified. Objective: We aimed to evaluate agreement between breathlessness severity an... Read More about Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study.

No excess harms from sustained-release morphine: A randomised placebo-controlled trial in chronic breathlessness (2019)
Journal Article
Johnson, M. J., Sbizzera, I., Fairhurst, C., Agar, M., Fazekas, B., Agar, M. R., Ekström, M., & Currow, D. C. (2019). No excess harms from sustained-release morphine: A randomised placebo-controlled trial in chronic breathlessness. BMJ supportive & palliative care, 10(4), 421-428. https://doi.org/10.1136/bmjspcare-2019-002009

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Objectives: We aimed to identify and evaluate: (1) treatment-emergent adverse events (TEAE (worse or new since baseline)) and the subgroup of... Read More about No excess harms from sustained-release morphine: A randomised placebo-controlled trial in chronic breathlessness.

Living well with breathlessness: How clinicians can help (2018)
Journal Article
Hutchinson, A., Barclay, N., Galvin, K., & Johnson, M. (2019). Living well with breathlessness: How clinicians can help. The British journal of general practice : the journal of the Royal College of General Practitioners, 69(678), 26-27. https://doi.org/10.3399/bjgp19X700505

None

Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review (2018)
Journal Article
Miller, J., Wells, L., Nwulu, U., Currow, D., Johnson, M. J., & Skipworth, R. J. (2018). Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review. American Journal of Clinical Nutrition, 108(6), 1196-1208. https://doi.org/10.1093/ajcn/nqy244

Background: There is great overlap between the presentation of cachexia, sarcopenia, and malnutrition. Distinguishing between these conditions would allow for better targeted treatment for patients. Objectives: The aim was to systematically review va... Read More about Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review.

Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial (2018)
Journal Article
Hutchinson, A., Rees, S., Young, A., Maraveyas, A., Date, K., & Johnson, M. J. (2019). Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial. Palliative medicine, 33(5), 510-517. https://doi.org/10.1177/0269216318815377

Background: Cancer patients have a four- to fivefold greater risk of thrombosis than the general population. Recommended treatment for cancer-associated thrombosis is 3–6 months of low-molecular-weight heparin. The ‘select-d’ trial is an open-label,... Read More about Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial.

Statistical compared to clinical significance and the risk of misattribution (2018)
Journal Article
Ekström, M., Johnson, M. J., & Currow, D. C. (2018). Statistical compared to clinical significance and the risk of misattribution. European respiratory journal, 52(5), Article 1801723. https://doi.org/10.1183/13993003.01723-2018

Response to “Hyoscine Butylbromide for the Management of Death Rattle: Sooner Rather Than Later” (2018)
Journal Article
Boland, J. W., Johnson, M., & Currow, D. (2019). Response to “Hyoscine Butylbromide for the Management of Death Rattle: Sooner Rather Than Later”. Journal of pain and symptom management, 57(3), e12-e13. https://doi.org/10.1016/j.jpainsymman.2018.11.018

Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study (2018)
Journal Article
Boland, J. W., Allgar, V., Boland, E. G., Kaasa, S., Hjermstad, M. J., & Johnson, M. J. (2019). Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study. Palliative medicine, 33(2), 206-212. https://doi.org/10.1177/0269216318811011

Background: Performance status, a predictor of cancer survival, and ability to maintain independent living deteriorate in advanced disease. Understanding predictors of performance status trajectory could help identify those at risk of functional dete... Read More about Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study.

Clinical decision-making at the end of life: A mixed-methods study (2018)
Journal Article
Taylor, P., Johnson, M. J., & Dowding, D. W. (in press). Clinical decision-making at the end of life: A mixed-methods study. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2018-001535

Objectives To improve the ability of clinical staff to recognise end of life in hospital inpatients dying as a result of cancer and heart failure, and to generate new hypotheses for further research.

Methods This mixed-methods study used decision th... Read More about Clinical decision-making at the end of life: A mixed-methods study.