The Role of High-density Lipoprotein in Oral and Dental Diseases

Sadeghalbanaei, Leila; Shirban, Farinaz; Bagherniya, Mohammad; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, transport of bioactive molecules, and induction of signal transduction pathways. Further, there is a mutual connection between oral health and general health. Hence HDL could be a poten-tially crucial factor relating oral health to general health. As far as we know, no compre-hensive study has been carried out to date, which has explored the association between HDL concentration and oral diseases including lichen plan, recurrent aphthous ulcers, candidiasis, implant osseointegration, oral cancer and precancerous conditions. Here in this review, we summarized the relationship between HDL and oral health, suggesting a significant association between HDL concentration and oral health.

Citation

Sadeghalbanaei, L., Shirban, F., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2023). The Role of High-density Lipoprotein in Oral and Dental Diseases. Current medicinal chemistry, 30(20), 2226-2246. https://doi.org/10.2174/0929867329666220901120654

• Journal Article Type: Review
• Acceptance Date: Sep 7, 2022
• Online Publication Date: Oct 21, 2022
• Publication Date: Mar 23, 2023
• Deposit Date: Apr 15, 2023
• Publicly Available Date: Oct 22, 2023
• Journal: Current Medicinal Chemistry
• Print ISSN: 0929-8673
• Electronic ISSN: 1875-533X
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 20
• Pages: 2226-2246
• DOI: https://doi.org/10.2174/0929867329666220901120654
• Keywords: HDL; Oropharyngeal cancer; Dental health; Oral health; Oral disease; Dental disease
• Public URL: https://hull-repository.worktribe.com/output/4261003