All Outputs (3)

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis (2021)
Journal Article
Yuan, T., Annamalai, K., Naik, S., Lupse, B., Geravandi, S., Pal, A., …Ardestani, A. (2021). The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nature communications, 12(1), Article 4928. https://doi.org/10.1038/s41467-021-25145-x

Diabetes results from a decline in functional pancreatic β-cells, but the molecular mechanisms underlying the pathological β-cell failure are poorly understood. Here we report that large-tumor suppressor 2 (LATS2), a core component of the Hippo signa... Read More about The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis.

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes (2021)
Journal Article
Lupse, B., Annamalai, K., Ibrahim, H., Kaur, S., Geravandi, S., Sarma, B., …Ardestani, A. (2021). Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. Cell reports, 36(5), Article 109490. https://doi.org/10.1016/j.celrep.2021.109490

Pancreatic β-cell failure is the key pathogenic element of the complex metabolic deterioration in type 2 diabetes (T2D); its underlying pathomechanism is still elusive. Here, we identify pleckstrin homology domain leucine-rich repeat protein phosphat... Read More about Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.

LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes (2021)
Journal Article
Sanchez, P. K. M., Khazaei, M., Gatineau, E., Geravandi, S., Lupse, B., Liu, H., …Ardestani, A. (2021). LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes. Biochemical and biophysical research communications, 568, 158-166. https://doi.org/10.1016/j.bbrc.2021.06.065

The lactate dehydrogenase isoform A (LDHA) is a key metabolic enzyme that preferentially catalyzes the conversion of pyruvate to lactate. Whereas LDHA is highly expressed in many tissues, its expression is turned off in the differentiated adult β-cel... Read More about LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.