The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization
(2013)
Journal Article
Shah, P., Ardestani, A., Dharmadhikari, G., Laue, S., Schumann, D. M., Kerr-Conte, J., …Maedler, K. (2013). The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization. Journal of Clinical Endocrinology and Metabolism, 98(7), E1163–E1172. https://doi.org/10.1210/jc.2013-1029
Context: Inhibition of dipeptidyl peptidase-4 (DPP-4) is a potent strategy to increase glucose-dependent insulinotropic polypeptide and glucagon like peptide 1 (GLP-1) induced insulin secretion in diabetes. It is important to know whether new drugs a... Read More about The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization.