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Lack of diastolic reserve in patients with heart failure and normal ejection fraction (2009)
Journal Article
Chattopadhyay, S., Alamgir, M. F., Nikitin, N. P., Rigby, A. S., Clark, A. L., & Cleland, J. G. F. (2010). Lack of diastolic reserve in patients with heart failure and normal ejection fraction. Circulation. Heart failure, 3(1), 35-43. https://doi.org/10.1161/CIRCHEARTFAILURE.108.824888

Background-The genesis of symptoms in patients with heart failure (HF) and normal ejection fraction (HFNEF) is unclear. Most investigations of HFNEF have focused on cardiac function at rest although most of these patients are breathless only on exerc... Read More about Lack of diastolic reserve in patients with heart failure and normal ejection fraction.

Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers? (2009)
Journal Article
Frankenstein, L., Goode, K., Ingle, L., Remppis, A., Schellberg, D., Nelles, M., Katus, H. A., Clark, A. L., Cleland, J. G. F., & Zugck, C. (2011). Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers?. International journal of cardiology, 147(1), 74-78. https://doi.org/10.1016/j.ijcard.2009.08.005

BACKGROUND It is unclear whether risk prediction strategies in chronic heart failure (CHF) need to be specific for sex or beta-blockers. We examined this problem and developed and validated the consequent risk models based on 6-minute-walk-test and N... Read More about Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers?.

Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure (2009)
Journal Article
Ingle, L., Isted, A., Witte, K. K., Cleland, J. G., & Clark, A. L. (2009). Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure. European journal of cardiovascular prevention and rehabilitation, 16(4), 451-456. https://doi.org/10.1097/HJR.0b013e32832a4f54

INTRODUCTION: Exertional oscillatory ventilation (EOV) occurs in many patients with chronic heart failure. Two different definitions of EOV have been proposed by Corrá and Leite. We aimed to compare the prevalence of EOV and its prognostic significan... Read More about Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure.

Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: Data from the OPTIMAAL trial (2009)
Journal Article
Anker, S. D., Voors, A., Okonko, D., Clark, A. L., James, M. K., von Haehling, S., …for the OPTIMAAL Investigators. (2009). Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: Data from the OPTIMAAL trial. European Heart Journal, 30(11), 1331-1339. https://doi.org/10.1093/eurheartj/ehp116

Aims The prevalence, incidence, and prognostic value of anaemia in patients with an acute myocardial infarction (AMI) complicated by heart failure is unclear. Methods and results We analysed the relationship between haemoglobin (Hb) and outcome in 50... Read More about Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: Data from the OPTIMAAL trial.

Prognostic Significance of the Double Pressure Reserve in Patients with Chronic Heart Failure (2009)
Journal Article
Ingle, L., & Clark, A. (2009). Prognostic Significance of the Double Pressure Reserve in Patients with Chronic Heart Failure. Open Heart Failure Journal, 2, 1-5. https://doi.org/10.2174/1876535100902010001

Abstract: Introduction: The double pressure reserve (DPR) has recently been shown to have greater prognostic power
than metabolic equivalents, heart rate indices, and systolic blood pressure in healthy subjects. It is unclear whether DPR
offers any... Read More about Prognostic Significance of the Double Pressure Reserve in Patients with Chronic Heart Failure.

Prolonged Electrical Muscle Stimulation Exercise Improves Strength, Peak VO2, and Exercise Capacity in Patients With Stable Chronic Heart Failure (2009)
Journal Article
Banerjee, P., Caulfield, B., Crowe, L., & Clark, A. L. (2009). Prolonged Electrical Muscle Stimulation Exercise Improves Strength, Peak VO2, and Exercise Capacity in Patients With Stable Chronic Heart Failure. Journal of cardiac failure, 15(4), 319-326. https://doi.org/10.1016/j.cardfail.2008.11.005

Background: Exercise training can help patients with chronic heart failure but may be limited in its applicability due to age and other comorbidities. This investigation evaluated training responses to prolonged electrical muscle stimulation (EMS) in... Read More about Prolonged Electrical Muscle Stimulation Exercise Improves Strength, Peak VO2, and Exercise Capacity in Patients With Stable Chronic Heart Failure.

The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age (2009)
Journal Article
Frankenstein, L., Clark, A. L., Goode, K., Ingle, L., Remppis, A., Schellberg, D., Grabs, F., Nelles, M., Cleland, J. G. F., Katus, H. A., & Zugck, C. (2009). The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age. Heart, 95(10), 825-829. https://doi.org/10.1136/hrt.2008.158626

Background: It is unclear whether age-related increases in N-terminal pro-brain natriuretic peptide (NT-proBNP) represent a normal physiological process - possibly affecting the prognostic power - of NT-proBNP - or reflect age-related subclinical pat... Read More about The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age.