All Outputs (2)

Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse (2011)
Journal Article
Matsakas, A., Macharia, R., Otto, A., Elashry, M. I., Mouisel, E., Romanello, V., Sartori, R., Amthor, H., Sandri, M., Narkar, V., & Patel, K. (2012). Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse. Experimental Physiology, 97(1), 125-140. https://doi.org/10.1113/expphysiol.2011.063008

Myostatin regulates both muscle mass and muscle metabolism. The myostatin null (MSTN -/- ) mouse has a hypermuscular phenotype owing to both hypertrophy and hyperplasia of the myofibres. The enlarged muscles display a reliance on glycolysis for ener... Read More about Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse.

Axon and muscle spindle hyperplasia in the myostatin null mouse (2011)
Journal Article
Elashry, M. I., Otto, A., Matsakas, A., El-Morsy, S. E., Jones, L., Anderson, B., & Patel, K. (2011). Axon and muscle spindle hyperplasia in the myostatin null mouse. Journal of anatomy, 218(2), 173-184. https://doi.org/10.1111/j.1469-7580.2010.01327.x

Germline deletion of the myostatin gene results in hyperplasia and hypertrophy of the tension-generating (extrafusal) fibres in skeletal muscle. As this gene is expressed predominantly in myogenic tissues it offers an excellent model with which to in... Read More about Axon and muscle spindle hyperplasia in the myostatin null mouse.