All Outputs (2)

A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6 (2018)
Journal Article
Keat, N., Kenny, J., Chen, K., Onega, M., Garman, N., Slack, R. J., Parker, C. A., Lumbers, R. T., Hallett, W., Saleem, A., Passchier, J., & Lukey, P. T. (2018). A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6. Journal of Nuclear Medicine Technology, 46(2), 136-143. https://doi.org/10.2967/jnmt.117.203547

The αvβ6 integrin is involved in the pathogenesis of cancer and fibrosis. A radiolabeled 20-amino-acid αvβ6-binding peptide, derived from the foot and mouth virus (NAVPNLRGDLQVLAQKVART [A20FMDV2]), has been developed to image αvβ6 levels preclinicall... Read More about A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6.

Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus (2018)
Journal Article
Narayan, N., Owen, D. R., Mandhair, H., Smyth, E., Carlucci, F., Saleem, A., Gunn, R. N., Rabiner, E. A., Wells, L., Dakin, S. G., Sabokbar, A., & Taylor, P. C. (2018). Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus. Journal of nuclear medicine, 59(7), 1125-1132. https://doi.org/10.2967/jnumed.117.202200

PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely report... Read More about Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus.