All Outputs (2)

Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro (2014)
Journal Article
Murray, B. S., Crot, S., Siankevich, S., & Dyson, P. J. (2014). Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro. Inorganic chemistry, 53(17), 9315-9321. https://doi.org/10.1021/ic501438k

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the... Read More about Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro.

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics (2014)
Journal Article
Murray, B. S., Menin, L., Scopelliti, R., & Dyson, P. J. (2014). Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics. Chemical science, 5(6), 2536-2545. https://doi.org/10.1039/c4sc00116h

Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative conf... Read More about Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics.