All Outputs (5)

Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles (2013)
Journal Article
Collier, M. E. W., Ettelaie, C., & Maraveyas, A. (2014). Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles. Thrombosis and haemostasis, 111(4), 647-655. https://doi.org/10.1160/TH13-09-0769

We previously reported that the incorporation of tissue factor (TF) into cell-derived microvesicles (MVs) is regulated by the phosphorylation of the cytoplasmic domain of TF. Since the cytoskeletal protein filamin-A is known to bind to the cytoplasmi... Read More about Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles.

Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity (2013)
Journal Article
Collier, M. E. W., Mah, P.-M., Xiao, Y., Maraveyas, A., & Ettelaie, C. (2013). Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity. Thrombosis and haemostasis, 110(5), 966-976. https://doi.org/10.1160/TH13-01-0055

In this study the uptake of tissue factor (TF)-positive microparticles by endothelial cells and the recycling of the TF component were examined. Human dermal blood endothelial cells (HDBEC) were incubated with microparticles derived from cancer cell... Read More about Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity.

p38 alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles (2013)
Journal Article
Ettelaie, C., ElKeeb, A. M., Maraveyas, A., & Collier, M. E. W. (2013). p38 alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles. BBA - Molecular Cell Research, 1833(3), 613-621. https://doi.org/10.1016/j.bbamcr.2012.11.010

We previously showed that the phosphorylation of Ser253 within the cytoplasmic domain of human tissue factor (TF) initiates the incorporation and release of this protein into cell-derived microparticles. Furthermore, subsequent phosphorylation of Ser... Read More about p38 alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles.

Examination of the up-regulation and transfer of tissue factor to endothelial cells by tumour-derived microparticles (2013)
Thesis
Mah, P. M. (2013). Examination of the up-regulation and transfer of tissue factor to endothelial cells by tumour-derived microparticles. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215976

Overexpression of tissue factor and its release as microparticles is a common feature of aggressive cancer. Furthermore, increased levels of tissue factor have been detected in the tumour associated microvascular endothelial cells. The accumulation o... Read More about Examination of the up-regulation and transfer of tissue factor to endothelial cells by tumour-derived microparticles.

Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor κB (2013)
Thesis
Fountain, D. L. (2013). Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor κB. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215936

The association between thrombosis and cancer has long been established. Tissue factor (TF), the initiator of the extrinsic pathway in the blood coagulation cascade, has been implicated as one of the most important physiological factors causing such... Read More about Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor κB.