[18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Burrows, N.; Gieling, R. G.; Morrow, C. J.; Forster, D.; Radigois, M.; Smigova, A.; Babur, M.; Hodgkinson, C.; Brown, G.; McMahon, A.; Dive, C.; Hiscock, D.; Wilson, I.; Williams, K. J.; Cawthorne, Christopher; Burrows, Natalie; Gieling, Roben G.; Morrow, Christopher J.; Forster, Duncan; Gregory, Jamil; Radigois, Marc; Smigova, Alison; Babur, Muhammad; Simpson, Kathryn; Hodgkinson, Cassandra; Brown, Gavin; McMahon, Adam; Dive, Caroline; Hiscock, Duncan; Wilson, Ian; Williams, Kaye J.

doi:10.1158/1535-7163.mct-12-0905

All Outputs (22)

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers (2013)
Journal Article
Simpson, K. L., Cawthorne, C., Zhou, C., Hodgkinson, C. L., Walker, M. J., Trapani, F., Kadirvel, M., Brown, G., Dawson, M. J., MacFarlane, M., Williams, K. J., Whetton, A. D., & Dive, C. (2013). A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death and Disease, 4(5), e613-e613. https://doi.org/10.1038/cddis.2013.137

Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal t... Read More about A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.

[18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941 (2013)
Journal Article
Cawthorne, C., Burrows, N., Gieling, R. G., Morrow, C. J., Forster, D., Gregory, J., Radigois, M., Smigova, A., Babur, M., Simpson, K., Hodgkinson, C., Brown, G., McMahon, A., Dive, C., Hiscock, D., Wilson, I., & Williams, K. J. (2013). [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941. Molecular Cancer Therapeutics, 12(5), 819-828. https://doi.org/10.1158/1535-7163.mct-12-0905

The phosphoinositide 3-kinase (PI3K) pathway is deregulated in a range of cancers, and several targeted inhibitors are entering the clinic. This study aimed to investigate whether the positron emission tomography tracer 3′-deoxy-3′-[ 18 F]fluorothymi... Read More about [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941.