The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance
(2018)
Journal Article
Mufti, A. H., Ogiwara, K., Swystun, L. L., Eikenboom, J. C. J., Budde, U., Hopman, W. M., Halldén, C., Goudemand, J., Peake, I. R., Goodeve, A. C., Lillicrap, D., Hampshire, D. J., & on behalf of the European Group on von Willebrand disease (EU-VWD) and Zimmerman Program for the Molecular and Clinical Biology of von Willebrand disease (ZPMCB-VWD) Study Groups. (2018). The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance. Blood Advances, 2(13), 1585-1594. https://doi.org/10.1182/bloodadvances.2017011643
Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VW... Read More about The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance.