All Outputs (2)

UV-light-driven prebiotic synthesis of iron–sulfur clusters (2017)
Journal Article
Szostak, J. W., Sasselov, D. D., Sutherland, J. D., Mansy, S. S., Bonfio, C., Valer, L., Scintilla, S., Shah, S., Evans, D. J., Jin, L., Szostak, J., Sasselov, D., Sutherland, J., & Mansy, S. (2017). UV-light-driven prebiotic synthesis of iron–sulfur clusters. Nature Chemistry, 9(12), 1229-1234. https://doi.org/10.1038/nchem.2817

Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the prebiotic chemistry that led to life. However, it is unclear whether iron–sulfur clusters could have been synthesized on prebiotic Earth.... Read More about UV-light-driven prebiotic synthesis of iron–sulfur clusters.

Plant-expressed hepatitis B core antigen virus-like particles : characterization and investigation of their stability in simulated and pig gastro-intestinal fluids (2017)
Journal Article
Berardi, A., Lomonossoff, G. P., Evans, D. J., & Barker, S. A. (2017). Plant-expressed hepatitis B core antigen virus-like particles : characterization and investigation of their stability in simulated and pig gastro-intestinal fluids. International Journal of Pharmaceutics, 522(1-2), 147-156. https://doi.org/10.1016/j.ijpharm.2017.03.001

Virus-like particles (VLPs) are potential oral vaccine candidates, as their highly compact structure may allow them to withstand the harsh conditions of the gastro-intestinal (GI) environment. Hepatitis B core antigen (HBcAg) is an immunogenic protei... Read More about Plant-expressed hepatitis B core antigen virus-like particles : characterization and investigation of their stability in simulated and pig gastro-intestinal fluids.