An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart.
(2020)
Presentation / Conference Contribution
Isaac, E., Cooper, S., Lancaster, M., Loubani, M., & Jones, S. An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart. Presented at Basic Cardiovascular Sciences Scientific Sessions 2020, Online
Background: Nav1.5 is the predominantly expressed voltage-gated sodium channel (VGSC) isoform in the heart, responsible for phase 0 of the action potential. Our rodent studies have shown expression of neuronal isoform Nav1.8 protein in the adult hear... Read More about An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart..