All Outputs (24)

Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study (2009)
Journal Article
Brayne, C., Richardson, K., Matthews, F. E., Fleming, J., Hunter, S., Xuereb, J. H., …Dening, T. (2009). Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study. Journal of Alzheimer's Disease, 18(3), 645-658. https://doi.org/10.3233/JAD-2009-1182

Key neuropathological changes associated with late-onset dementia are not fully understood. Population-based longitudinal studies offer an opportunity to step back and examine which pathological indices best link to clinical state. CC75C is a longitu... Read More about Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study.

Biomarkers, dementia, and public health (2009)
Journal Article
Wright, C. F., Hall, A., Matthews, F. E., & Brayne, C. (2009). Biomarkers, dementia, and public health. Annals of the New York Academy of Sciences, 1180, 11-19. https://doi.org/10.1111/j.1749-6632.2009.04942.x

Public health is defined as the organized efforts of society to improve health. This is often framed in terms of prevention, with primary, secondary, and tertiary prevention representing, respectively, fundamental prevention through understanding of... Read More about Biomarkers, dementia, and public health.

Hippocampal tau pathology is related to neuroanatomical connections: An ageing population-based study (2009)
Journal Article
Lace, G., Savva, G. M., Forster, G., De Silva, R., Brayne, C., Matthews, F. E., …Wharton, S. B. (2009). Hippocampal tau pathology is related to neuroanatomical connections: An ageing population-based study. Brain, 132(5), 1324-1334. https://doi.org/10.1093/brain/awp059

Deposits of abnormally phosphorylated tau protein are found in numerous neurodegenerative disorders; the 'tauopathies', which include Alzheimers and Picks diseases, but tau pathology is also found in the ageing brain. Variation in tau pathology in br... Read More about Hippocampal tau pathology is related to neuroanatomical connections: An ageing population-based study.

Education differences in life expectancy with cognitive impairment (2009)
Journal Article
Matthews, F. E., Jagger, C., Miller, L. L., & Brayne, C. (2009). Education differences in life expectancy with cognitive impairment. The journals of gerontology. Series A, Biological sciences and medical sciences, 64(1), 125-131. https://doi.org/10.1093/gerona/gln003

Background. Low education has an impact on life expectancy and level of cognition, but little is known on its effect on life expectancy with cognitive impairment. Methods. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) co... Read More about Education differences in life expectancy with cognitive impairment.