All Outputs (25)

Understanding patterns of capability loss among elderly users (2009)
Presentation / Conference Contribution
Seidel, D., Crilly, N., Langdon, P. M., Matthews, F. E., Jagger, C., Brayne, C., & Clarkson, P. J. (2009). Understanding patterns of capability loss among elderly users.

The objective of this study was to understand patterns of capability loss among elderly users of products and services. Data from a longitudinal, population-based study were obtained for analysis, which recruited a representative sample of 13,004 peo... Read More about Understanding patterns of capability loss among elderly users.

APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA study (2009)
Journal Article
Keage, H. A., Matthews, F. E., Yip, A., Gao, L., McCracken, C., McKeith, I. G., …Brayne, C. (2009). APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA study. Age and ageing, 39(1), 104-111. https://doi.org/10.1093/ageing/afp210

Background: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate on incident dementia... Read More about APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA study.

Recovery in instrumental activities of daily living (IADLs): Findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2009)
Journal Article
Seidel, D., Jagger, C., Brayne, C., & Matthews, F. E. (2009). Recovery in instrumental activities of daily living (IADLs): Findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Age and ageing, 38(6), 663-668. https://doi.org/10.1093/ageing/afp128

Objective: to provide evidence for predictors of recovery in instrumental activities of daily living (IADLs) among disabled older people living in the community. Design: MRC CFAS recruited a sample of 13,004 individuals aged 65 years and above from f... Read More about Recovery in instrumental activities of daily living (IADLs): Findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

Epidemiological pathology of dementia: Attributable-risks at death in the medical research council cognitive function and ageing study (2009)
Journal Article
Matthews, F. E., Brayne, C., Lowe, J., McKeith, I., Wharton, S. B., & Ince, P. (2009). Epidemiological pathology of dementia: Attributable-risks at death in the medical research council cognitive function and ageing study. PLoS Medicine, 6(11), https://doi.org/10.1371/journal.pmed.1000180

Background: Dementia drug development aims to modulate pathological processes that cause clinical syndromes. Population data (epidemiological neuropathology) will help to model and predict the potential impact of such therapies on dementia burden in... Read More about Epidemiological pathology of dementia: Attributable-risks at death in the medical research council cognitive function and ageing study.

Patterns of functional loss among older people: A prospective analysis (2009)
Journal Article
Seidel, D., Crilly, N., Matthews, F. E., Jagger, C., Clarkson, P. J., & Brayne, C. (2009). Patterns of functional loss among older people: A prospective analysis. Human Factors, 51(5), 669-680. https://doi.org/10.1177/0018720809353597

Objective: Patterns of capability loss and disability onset among older people were investigated prospectively. Background: With aging, the gap between personal capability and environmental demand becomes wider, resulting in higher levels of disabili... Read More about Patterns of functional loss among older people: A prospective analysis.

Estimating dementia-free life expectancy for Parkinson's patients using Bayesian inference and microsimulation (2009)
Journal Article
Van Den Hout, A., & Matthews, F. E. (2009). Estimating dementia-free life expectancy for Parkinson's patients using Bayesian inference and microsimulation. Biostatistics, 10(4), 729-743. https://doi.org/10.1093/biostatistics/kxp027

Interval-censored longitudinal data taken from a Norwegian study of individuals with Parkinson's disease are investigated with respect to the onset of dementia. Of interest are risk factors for dementia and the subdivision of total life expectancy (L... Read More about Estimating dementia-free life expectancy for Parkinson's patients using Bayesian inference and microsimulation.

Estimating life expectancy in health and ill health by using a hidden markov model (2009)
Journal Article
Van Den Hout, A., Jagger, C., & Matthews, F. E. (2009). Estimating life expectancy in health and ill health by using a hidden markov model. Journal of the Royal Statistical Society: Series C, 58(4), 449-465. https://doi.org/10.1111/j.1467-9876.2008.00659.x

Summary. Population studies with longitudinal follow-up and mortality information can be used to estimate transitions between healthy and unhealthy states before death. When health is defined with respect to cognitive ability during old age, the traj... Read More about Estimating life expectancy in health and ill health by using a hidden markov model.

Development and validation of risk score for predicting positive repeat prostate biopsy in patients with a previous negative biopsy in a UK population (2009)
Journal Article
Rochester, M. A., Pashayan, N., Matthews, F., Doble, A., & McLoughlin, J. (2009). Development and validation of risk score for predicting positive repeat prostate biopsy in patients with a previous negative biopsy in a UK population. BMC Urology, 9(1), https://doi.org/10.1186/1471-2490-9-7

Background. Little evidence is available to determine which patients should undergo repeat biopsy after initial benign extended core biopsy (ECB). Attempts have been made to reduce the frequency of negative repeat biopsies using PSA kinetics, density... Read More about Development and validation of risk score for predicting positive repeat prostate biopsy in patients with a previous negative biopsy in a UK population.

A piecewise-constant Markov model and the effects of study design on the estimation of life expectancies in health and ill health (2009)
Journal Article
van den Hout, A., & Matthews, F. E. (2009). A piecewise-constant Markov model and the effects of study design on the estimation of life expectancies in health and ill health. Statistical Methods in Medical Research, 18(2), 145-162. https://doi.org/10.1177/0962280208089090

Multi-state models are frequently applied to describe transitions over time between three states: healthy, not healthy and death. The three-state model can be used to estimate life expectancies in health and ill health. In this article, continuous-ti... Read More about A piecewise-constant Markov model and the effects of study design on the estimation of life expectancies in health and ill health.

Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: A population based neuropathological cohort study (2009)
Journal Article
Byford, M., Brayne, C., McKeith, I., Chatfield, M., Ince, P., & Matthews, F. (2009). Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: A population based neuropathological cohort study. BMC Geriatrics, 9(1), https://doi.org/10.1186/1471-2318-9-22

Background. Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in subcortical areas of the brain associated... Read More about Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: A population based neuropathological cohort study.

Prevalence of autism-spectrum conditions: UK school-based population study (2009)
Journal Article
Baron-Cohen, S., Scott, F. J., Allison, C., Williams, J., Bolton, P., Matthews, F. E., & Brayne, C. (2009). Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry, 194(6), 500-509. https://doi.org/10.1192/bjp.bp.108.059345

Background: Recent reports estimate the prevalence of autism-spectrum conditions in the UK to be 1%. Aims: To use different methods to estimate the prevalence of autism-spectrum conditions, including previously undiagnosed cases, in Cambridgeshire. M... Read More about Prevalence of autism-spectrum conditions: UK school-based population study.

Population variation in glial fibrillary acidic protein levels in brain ageing: Relationship to alzheimer-type pathology and dementiaon behalf of the MRC cognitive function and ageing neuropathology study group (2009)
Journal Article
Wharton, S. B., O'Callaghan, J. P., Savva, G. M., Nicoll, J. A., Matthews, F., Simpson, J. E., …Ince, P. G. (2009). Population variation in glial fibrillary acidic protein levels in brain ageing: Relationship to alzheimer-type pathology and dementiaon behalf of the MRC cognitive function and ageing neuropathology study group. Dementia and Geriatric Cognitive Disorders, 27(5), 465-473. https://doi.org/10.1159/000217729

Background: The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood. Methods: Using quantitative ELISA, we have investigated glial fibrillary... Read More about Population variation in glial fibrillary acidic protein levels in brain ageing: Relationship to alzheimer-type pathology and dementiaon behalf of the MRC cognitive function and ageing neuropathology study group.

Age, neuropathology, and dementia (2009)
Journal Article
Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009). Age, neuropathology, and dementia. New England Journal of Medicine, 360(22), 2302-2309. https://doi.org/10.1056/NEJMoa0806142

BACKGROUND: Research in Alzheimer's disease is focused mainly on younger old persons, whereas studies involving very old persons report attenuated relationships between the pathological features of Alzheimer's disease and dementia. METHODS: We assess... Read More about Age, neuropathology, and dementia.

What will happen if we do nothing to control trachoma: Health expectancies for blinding trachoma in Southern Sudan (2009)
Journal Article
Ngondi, J. M., Matthews, F. E., Reacher, M. H., King, J., Brayne, C., Gouda, H., & Emerson, P. M. (2009). What will happen if we do nothing to control trachoma: Health expectancies for blinding trachoma in Southern Sudan. PLoS Neglected Tropical Diseases, 3(3), https://doi.org/10.1371/journal.pntd.0000396

Background: Uncontrolled trachoma is a leading cause of blindness. Current global trachoma burden summary measures are presented as disability adjusted life years but have limitations due to inconsistent methods and inadequate population-based data o... Read More about What will happen if we do nothing to control trachoma: Health expectancies for blinding trachoma in Southern Sudan.

Education and trajectories of cognitive decline over 9 years in very old people: Methods and risk analysis (2009)
Journal Article
Muniz-terrera, G., Matthews, F., Dening, T., Huppert, F. A., & Brayne, C. (2009). Education and trajectories of cognitive decline over 9 years in very old people: Methods and risk analysis. Age and ageing, 38(3), 277-282. https://doi.org/10.1093/ageing/afp004

Background: the investigation of cognitive decline in the older population has been hampered by analytical considerations. Most studies of older people over prolonged periods suffer from loss to follow-up, yet this has seldom been investigated fully... Read More about Education and trajectories of cognitive decline over 9 years in very old people: Methods and risk analysis.

Exposure to secondhand smoke and cognitive impairment in non-smokers: National cross sectional study with cotinine measurement (2009)
Journal Article
Llewellyn, D. J., Lang, L. A., Langa, K. M., Naughton, F., & Matthews, F. E. (2009). Exposure to secondhand smoke and cognitive impairment in non-smokers: National cross sectional study with cotinine measurement. BMJ, 338(7695), https://doi.org/10.1136/bmj.b462

Objective To examine the association between a biomarker of exposure to secondhand smoke (salivary cotinine concentration) and cognitive impairment. Design Cross sectional analysis of a national population based study. Setting Stratified random sampl... Read More about Exposure to secondhand smoke and cognitive impairment in non-smokers: National cross sectional study with cotinine measurement.

Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population (2009)
Journal Article
Savva, G. M., Zaccai, J., Matthews, F. E., Davidson, J. E., McKeith, I., & Brayne, C. (2009). Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. British Journal of Psychiatry, 194(3), 212-219. https://doi.org/10.1192/bjp.bp.108.049619

Background Behavioural and psychological symptoms of dementia (BPSD) are major contributors to the burden of dementia. Aims To describe the prevalence, correlates and course of BPSD in the population of England and Wales. Method The prevalence of 12... Read More about Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population.

Risk factors for trachomatous trichiasis in children: cross-sectional household surveys in Southern Sudan (2009)
Journal Article
Ngondi, J., Reacher, M. H., Matthews, F. E., Brayne, C., Gatpan, G., Becknell, S., …Emerson, P. M. (2009). Risk factors for trachomatous trichiasis in children: cross-sectional household surveys in Southern Sudan. Transactions of The Royal Society of Tropical Medicine and Hygiene, 103(3), 305-314. https://doi.org/10.1016/j.trstmh.2008.08.024

We have previously documented blinding trachoma to be a serious public health problem in Southern Sudan, with an unusually high prevalence of trachomatous trichiasis (TT) among children. We aimed to investigate risk factors for TT in children in Sout... Read More about Risk factors for trachomatous trichiasis in children: cross-sectional household surveys in Southern Sudan.

Trachoma survey methods: A literature review (2009)
Journal Article
Ngondi, J., Reacher, M., Matthews, F., Brayne, C., & Emerson, P. (2009). Trachoma survey methods: A literature review. Bulletin of the World Health Organization, 87(2), 143-151. https://doi.org/10.2471/BLT.07.046326

Reliable population-based prevalence data are essential for planning, monitoring and evaluating trachoma control programmes and understanding the scale of the problem, yet they are not currently available for 22 out of 56 trachoma-endemic countries.... Read More about Trachoma survey methods: A literature review.

Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways (2009)
Journal Article
Simpson, J. E., Hosny, O., Wharton, S. B., Heath, P. R., Holden, H., Fernando, M. S., …Ince, P. G. (2009). Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways. Stroke, 40(2), 369-375. https://doi.org/10.1161/STROKEAHA.108.529214

Background and Purpose-White matter lesions (WML) in brain aging are linked to dementia and depression. Ischemia contributes to their pathogenesis but other mechanisms may contribute. We used RNA microarray analysis with functional pathway grouping a... Read More about Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.