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Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies (2020)
Journal Article
Waller, R., Narramore, R., Simpson, J. E., Heath, P. R., Verma, N., Tinsley, M., Barnes, J. R., Haris, H. T., Henderson, F. E., Matthews, F. E., Richardson, C. D., Brayne, C., Ince, P. G., Kalaria, R. N., & Wharton, S. B. (2021). Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies. Brain Pathology, 31(3), Article e12928. https://doi.org/10.1111/bpa.12928

White matter lesions (WML) are common in the ageing brain, often arising in a field effect of diffuse white matter abnormality. Although WML are associated with cerebral small vessel disease (SVD) and Alzheimer’s disease (AD), their cause and pathoge... Read More about Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies.

Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study (2020)
Journal Article
Röhr, S., Pabst, A., Riedel-Heller, S. G., Jessen, F., Turana, Y., Handajani, Y. S., Brayne, C., Matthews, F. E., Stephan, B. C., Lipton, R. B., Katz, M. J., Wang, C., Guerchet, M., Preux, P. M., Mbelesso, P., Ritchie, K., Ancelin, M. L., Carrière, I., Guaita, A., Davin, A., …Sachdev, P. S. (2020). Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimer's Research and Therapy, 12(1), Article 167. https://doi.org/10.1186/s13195-020-00734-y

Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across internation... Read More about Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study.

Timing of GP end-of-life recognition in people aged ≥75 years: Retrospective cohort study using data from primary healthcare records in England (2020)
Journal Article
Stow, D., Matthews, F. E., & Hanratty, B. (2020). Timing of GP end-of-life recognition in people aged ≥75 years: Retrospective cohort study using data from primary healthcare records in England. The British journal of general practice : the journal of the Royal College of General Practitioners, 70(701), E874-E879. https://doi.org/10.3399/bjgp20X713417

Background High-quality, personalised palliative care should be available to all, but timely recognition of end of life may be a barrier to end-of-life care for older people. Aim To investigate the timing of end-of-life recognition, palliative regist... Read More about Timing of GP end-of-life recognition in people aged ≥75 years: Retrospective cohort study using data from primary healthcare records in England.

Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies? (2020)
Journal Article
Barker, R. O., Hanratty, B., Kingston, A., Ramsay, S. E., & Matthews, F. E. (2021). Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies?. Age and ageing, 50(3), 921-927. https://doi.org/10.1093/ageing/afaa227

Background: Care home residents have complex care and support needs. There is a perception that the needs of residents have increased, but the evidence is limited. We investigated changes in health and functioning of care home residents over two deca... Read More about Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies?.

Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response (2020)
Journal Article
Fadul, M. M., Heath, P. R., Cooper-Knock, J., Kurz, J. M., Al-Azzawi, H. A., Ali, Z., Smith, T., Matthews, F. E., Brayne, C., Wharton, S. B., & Simpson, J. E. (2020). Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21(21), Article 7924. https://doi.org/10.3390/ijms21217924

White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular lesions (PVL, n = 7) and radiologically-normal-appearing (control) periventricular white matter... Read More about Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response.

Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study (2020)
Journal Article
Hamilton, C. A., Matthews, F. E., Donaghy, P. C., Taylor, J. P., O'Brien, J. T., Barnett, N., Olsen, K., Lloyd, J., Petrides, G., McKeith, I. G., & Thomas, A. J. (2021). Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study. American Journal of Geriatric Psychiatry, 29(3), 272-284. https://doi.org/10.1016/j.jagp.2020.07.018

Objective: We explored whether the mild cognitive impairment (MCI) stages of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) differ in their cognitive profiles, and longitudinal progression. Design: A prospective, longitudinal design was u... Read More about Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study.

Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort (2020)
Journal Article
Chambers, A., Bury, J. J., Minett, T., Richardson, C. D., Brayne, C., Ince, P. G., Shaw, P. J., Garwood, C. J., Heath, P. R., Simpson, J. E., Matthews, F. E., & Wharton, S. B. (2020). Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort. Journal of Neuropathology & Experimental Neurology, 79(9), 950-958. https://doi.org/10.1093/JNEN/NLAA064

Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of macromolecules results in formation of advanced glycation end-products (AGEs). We determined the variation in AGE formation in brains from the Cognitive Function and A... Read More about Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort.

Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia (2020)
Journal Article
Zheng, L., Matthews, F. E., & Anstey, K. J. (2021). Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia. Age and ageing, 50(1), 169-175. https://doi.org/10.1093/ageing/afaa111

Background: Cognitive health expectancy estimates the proportion of the lifespan that is lived in good cognitive health at the population level. A number of cardiovascular diseases have been identified to be risk factors for cognitive decline and dem... Read More about Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia.

Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II (2020)
Journal Article
Grossi, C. M., Richardson, K., Savva, G. M., Fox, C., Arthur, A., Loke, Y. K., Steel, N., Brayne, C., Matthews, F. E., Robinson, L., Myint, P. K., & Maidment, I. D. (2020). Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II. BMC Geriatrics, 20(1), Article 267. https://doi.org/10.1186/s12877-020-01657-x

Background: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in England's older populatio... Read More about Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II.

Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., Zammit, A., Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Archives of Gerontology and Geriatrics, 91, Article 104112. https://doi.org/10.1016/j.archger.2020.104112

Background: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4). Methods: Parti... Read More about Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment.

Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium (2020)
Journal Article
Wolters, F. J., Chibnik, L. B., Waziry, R., Anderson, R., Berr, C., Beiser, A., Bis, J. C., Blacker, D., Bos, D., Brayne, C., Dartigues, J. F., Darweesh, S. K., Davis-Plourde, K. L., De Wolf, F., Debette, S., Dufouil, C., Fornage, M., Goudsmit, J., Grasset, L., Gudnason, V., …Hofman, A. (2020). Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology, 95(5), E519-E531. https://doi.org/10.1212/WNL.0000000000010022

Objective To determine changes in the incidence of dementia between 1988 and 2015.MethodsThis analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Al... Read More about Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.

Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis (2020)
Journal Article
Pieper, N. T., Grossi, C. M., Chan, W. Y., Loke, Y. K., Savva, G. M., Haroulis, C., Steel, N., Fox, C., Maidment, I. D., Arthur, A. J., Myint, P. K., Smith, T. O., Robinson, L., Matthews, F. E., Brayne, C., & Richardson, K. (2020). Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis. Age and ageing, 49(6), 939-947. https://doi.org/10.1093/ageing/afaa090

Background: the long-term effect of the use of drugs with anticholinergic activity on cognitive function remains unclear. Methods: we conducted a systematic review and meta-analysis of the relationship between anticholinergic drugs and risk of dement... Read More about Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis.

The COVID-19 pandemic and health inequalities (2020)
Journal Article
Bambra, C., Riordan, R., Ford, J., & Matthews, F. (2020). The COVID-19 pandemic and health inequalities. Journal of Epidemiology and Community Health, 74(11), 964-968. https://doi.org/10.1136/jech-2020-214401

This essay examines the implications of the COVID-19 pandemic for health inequalities. It outlines historical and contemporary evidence of inequalities in pandemics - drawing on international research into the Spanish influenza pandemic of 1918, the... Read More about The COVID-19 pandemic and health inequalities.

APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., CuilingWang, Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline. The journals of gerontology. Series A, Biological sciences and medical sciences, 75(10), 1863-1873. https://doi.org/10.1093/gerona/glaa116

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals ag... Read More about APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline.

Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease (2020)
Journal Article
Hamilton, C. A., Matthews, F. E., Donaghy, P. C., Taylor, J. P., O'Brien, J. T., Barnett, N., …Thomas, A. J. (2021). Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease. Psychological Medicine, 51(15), 2590-2598. https://doi.org/10.1017/S0033291720001130

Background Mild cognitive impairment (MCI) may gradually worsen to dementia, but often remains stable for extended periods of time. Little is known about the predictors of decline to help explain this variation. We aimed to explore whether this heter... Read More about Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease.

Prevalence and determinants of loneliness in people living with dementia: Findings from the IDEAL programme (2020)
Journal Article
Victor, C. R., Rippon, I., Nelis, S. M., Martyr, A., Litherland, R., Pickett, J., Hart, N., Henley, J., Matthews, F., & Clare, L. (2020). Prevalence and determinants of loneliness in people living with dementia: Findings from the IDEAL programme. International journal of geriatric psychiatry, 35(8), 851-858. https://doi.org/10.1002/gps.5305

Objective: To establish the prevalence and determinants of loneliness among people living with dementia. Methods: Using data from the baseline wave of the Improving the experience of Dementia and Enhancing Active Life (IDEAL) cohort study, we examine... Read More about Prevalence and determinants of loneliness in people living with dementia: Findings from the IDEAL programme.

Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences (2020)
Journal Article
Liu, K. Y., Kievit, R. A., Tsvetanov, K. A., Betts, M. J., Düzel, E., Rowe, J. B., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Henson, R. N., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., …Hämmerer, D. (2020). Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences. Nature communications, 11(1), Article 1712. https://doi.org/10.1038/s41467-020-15410-w

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differenc... Read More about Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences.

Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory (2020)
Journal Article
Wolpe, N., Ingram, J. N., Tsvetanov, K. A., Henson, R. N., Wolpert, D. M., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., Geerligs, L., Kievit, R., …Rowe, J. B. (2020). Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory. Neurobiology of Aging, 90, 13-23. https://doi.org/10.1016/j.neurobiolaging.2020.02.016

The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in “explicit” learning processes. We examine differences in brain structure and cogn... Read More about Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory.

Factors associated with self- And informant ratings of quality of life,well-being and life satisfaction in people with mild-to-moderate dementia: Results from the improving the experience of dementia and enhancing active life programme (2020)
Journal Article
Wu, Y. T., Nelis, S. M., Quinn, C., Martyr, A., Jones, I. R., Victor, C. R., Knapp, M., Henderson, C., Hindle, J. V., Jones, R. W., Kopelman, M. D., Morris, R. G., Pickett, J. A., Rusted, J. M., Thom, J. M., Litherland, R., Matthews, F. E., & Clare, L. (2020). Factors associated with self- And informant ratings of quality of life,well-being and life satisfaction in people with mild-to-moderate dementia: Results from the improving the experience of dementia and enhancing active life programme. Age and ageing, 49(3), 446-452. https://doi.org/10.1093/ageing/afz177

Background: A large number of studies have explored factors related to self- and informant ratings of quality of life in people with dementia, but many studies have had relatively small sample sizes and mainly focused on health conditions and dementi... Read More about Factors associated with self- And informant ratings of quality of life,well-being and life satisfaction in people with mild-to-moderate dementia: Results from the improving the experience of dementia and enhancing active life programme.