All Outputs (373)

Relocation at older age: Results from the Cognitive Function and Ageing Study (2015)
Journal Article
Wu, Y. T., Prina, A. M., Barnes, L. E., Matthews, F. E., & Brayne, C. (2015). Relocation at older age: Results from the Cognitive Function and Ageing Study. Journal of Public Health, 37(3), 480-487. https://doi.org/10.1093/pubmed/fdv050

Background Community environment might play an important role in supporting ageing in place. This paper aims to explore relocation at older age and its associations with individual and community level factors. Methods The postcodes of the 2424 people... Read More about Relocation at older age: Results from the Cognitive Function and Ageing Study.

Changing non-participation in epidemiological studies of older people: Evidence from the Cognitive Function and Ageing Study I and II (2015)
Journal Article
Gao, L., Green, E., Barnes, L. E., Brayne, C., Matthews, F. E., Robinson, L., & Arthur, A. (2015). Changing non-participation in epidemiological studies of older people: Evidence from the Cognitive Function and Ageing Study I and II. Age and ageing, 44(5), 867-873. https://doi.org/10.1093/ageing/afv101

Background: non-participation in epidemiological studies threatens the generalisability of findings. Objective: to investigate the change in non-participation between the Medical Research Council Cognitive Function and Ageing Study (CFAS) I and II. D... Read More about Changing non-participation in epidemiological studies of older people: Evidence from the Cognitive Function and Ageing Study I and II.

Oxidative glial cell damage associated with white matter lesions in the aging human brain (2015)
Journal Article
Al-Mashhadi, S., Simpson, J. E., Heath, P. R., Dickman, M., Forster, G., Matthews, F. E., …Wharton, S. B. (2015). Oxidative glial cell damage associated with white matter lesions in the aging human brain. Brain Pathology, 25(5), 565-574. https://doi.org/10.1111/bpa.12216

White matter lesions (WML) are common in brain aging and are associated with dementia. We aimed to investigate whether oxidative DNA damage and occur in WML and in apparently normal white matter in cases with lesions. Tissue from WML and control whit... Read More about Oxidative glial cell damage associated with white matter lesions in the aging human brain.

Prevalence of dementia in East Asia: A synthetic review of time trends (2015)
Journal Article
Wu, Y. T., Brayne, C., & Matthews, F. E. (2015). Prevalence of dementia in East Asia: A synthetic review of time trends. International journal of geriatric psychiatry, 30(8), 793-801. https://doi.org/10.1002/gps.4297

Objective This study aims to synthesise evidence on time trends of dementia prevalence in East Asian countries including Japan, China, South Korea and Taiwan and assess the impact of the societal changes on future prevalence. Method Relevant reviews... Read More about Prevalence of dementia in East Asia: A synthetic review of time trends.

Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing (2015)
Journal Article
Sun, X., Allison, C., Matthews, F. E., Zhang, Z., Auyeung, B., Baron-Cohen, S., & Brayne, C. (2015). Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing. Autism Research, 8(3), 250-260. https://doi.org/10.1002/aur.1441

Previous studies reported that the prevalence of Autism Spectrum Conditions (ASC) in mainland China is much lower than estimates from developed countries (around 1%). The aim of the study is to apply current screening and standardized diagnostic inst... Read More about Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing.

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort (2015)
Journal Article
Simpson, J. E., Ince, P. G., Matthews, F. E., Shaw, P. J., Heath, P. R., Brayne, C., …Wharton, S. B. (2015). A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41(4), 483-496. https://doi.org/10.1111/nan.12202

Aims: Population-based studies have shown that approximately 20% of the ageing population (aged 65 years and over) with dementia have little or no classical Alzheimer-type neuropathology. Cumulative DNA damage and a reduced capacity of DNA repair may... Read More about A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.

Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly (2015)
Journal Article
Zaccai, J., Brayne, C., Matthews, F. E., & Ince, P. G. (2015). Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly. Alzheimer's Research and Therapy, 7(1), https://doi.org/10.1186/s13195-015-0101-x

Introduction: Studies with strong selection biases propose that alpha-synucleinopathy (AS) spreads upwards and downwards in the neuraxis from the medulla, that amygdala-dominant AS is strongly associated with Alzheimer's disease (AD), and that a more... Read More about Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly.

A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment (2015)
Journal Article
Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., …Wharton, S. B. (2015). A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment. PLoS ONE, 10(2), https://doi.org/10.1371/journal.pone.0118463

Aims β-amyloid (Aβ) plaques are a key feature of Alzheimer's disease pathology but correlate poorly with dementia. They are associated with astrocytes which may modulate the effect of Aβ-deposition on the neuropil. This study characterised the astroc... Read More about A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept? (2015)
Journal Article
Stephan, B. C., Minett, T., Terrera, G. M., Matthews, F. E., & Brayne, C. (2015). Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept?. Age and ageing, 44(1), 78-83. https://doi.org/10.1093/AGEING/AFU085

Background: criteria for mild cognitive impairment (MCI) capture an intermediate cognitive state between normal ageing and dementia, associated with increased dementia risk. Whether criteria for MCI are applicable in the context of stroke and can be... Read More about Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept?.

Older people, the natural environment and common mental disorders: Cross-sectional results from the Cognitive Function and Ageing Study (2015)
Journal Article
Wu, Y. T., Prina, A. M., Jones, A., Matthews, F. E., & Brayne, C. (2015). Older people, the natural environment and common mental disorders: Cross-sectional results from the Cognitive Function and Ageing Study. BMJ open, 5(9), https://doi.org/10.1136/bmjopen-2015-007936

Objectives: To explore the hypothesis that higher exposure to natural environments in local areas is associated with a lower odds of depression and anxiety in later life. Design: A cross-sectional study based on the year-10 interview of the Medical R... Read More about Older people, the natural environment and common mental disorders: Cross-sectional results from the Cognitive Function and Ageing Study.

Cognitive function in a general population of men and women: A cross sectional study in the European Investigation of Cancer-Norfolk cohort (EPIC-Norfolk) (2015)
Journal Article
Hayat, S. A., Luben, R., Moore, S., Dalzell, N., Bhaniani, A., Anuj, S., …Brayne, C. (2015). Cognitive function in a general population of men and women: A cross sectional study in the European Investigation of Cancer-Norfolk cohort (EPIC-Norfolk). BMC Geriatrics, 14(1), https://doi.org/10.1186/1471-2318-14-142

Background: Although ageing is strongly associated with cognitive decline, a wide range of cognitive ability is observed in older populations with varying rates of change across different cognitive domains. Methods: Cognitive function was measured as... Read More about Cognitive function in a general population of men and women: A cross sectional study in the European Investigation of Cancer-Norfolk cohort (EPIC-Norfolk).

Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis (2014)
Journal Article
Wu, Y. T., Lee, H. Y., Norton, S., Prina, A. M., Fleming, J., Matthews, F. E., & Brayne, C. (2014). Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis. International journal of geriatric psychiatry, 29(12), 1212-1220. https://doi.org/10.1002/gps.4148

Objective: There have been dramatic societal changes in East Asia over the last hundred years. Several of the established risk factors could have important period and cohort effects. This study explores temporal variation of dementia prevalence in ma... Read More about Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis.

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: A population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort (2014)
Journal Article
Garwood, C. J., Simpson, J. E., Al Mashhadi, S., Axe, C., Wilson, S., Heath, P. R., …Wharton, S. B. (2014). DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: A population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort. Neuropathology and Applied Neurobiology, 40(7), 802-814. https://doi.org/10.1111/nan.12156

Aims: Abnormalities of the brain microvasculature in Alzheimer's disease have led to the vascular hypothesis of the disease, which predicts that vascular changes precede neuronal dysfunction and degeneration. To determine the spectrum of endothelial... Read More about DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: A population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.

The descriptive epidemiology of delirium symptoms in a large population-based cohort study: Results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2014)
Journal Article
Davis, D. H., Barnes, L. E., Stephan, B. C., Maclullich, A. M., Meagher, D., Copeland, J., …Brayne, C. (2014). The descriptive epidemiology of delirium symptoms in a large population-based cohort study: Results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC Geriatrics, 14(1), https://doi.org/10.1186/1471-2318-14-87

Background: In the general population, the epidemiological relationships between delirium and adverse outcomes are not well defined. The aims of this study were to: (1) construct an algorithm for the diagnosis of delirium using the Geriatric Mental S... Read More about The descriptive epidemiology of delirium symptoms in a large population-based cohort study: Results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

Gender differences in life expectancy free of impairment at older ages (2014)
Book Chapter
Jagger, C., & Matthews, F. (2014). Gender differences in life expectancy free of impairment at older ages.

C-reactive protein, APOE genotype and longitudinal cognitive change in an older population (2014)
Journal Article
Lima, T. A., Adler, A. L., Minett, T., Matthews, F. E., Brayne, C., & Marioni, R. E. (2014). C-reactive protein, APOE genotype and longitudinal cognitive change in an older population. Age and ageing, 43(2), 289-292. https://doi.org/10.1093/ageing/aft193

Background: circulating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cro... Read More about C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.

The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing (2014)
Journal Article
Shafto, M. A., Tyler, L. K., Dixon, M., Taylor, J. R., Rowe, J. B., Cusack, R., …Matthews, F. E. (2014). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing. BMC Neurology, 14(1), https://doi.org/10.1186/s12883-014-0204-1

Background: As greater numbers of us are living longer, it is increasingly important to understand how we can age healthily. Although old age is often stereotyped as a time of declining mental abilities and inflexibility, cognitive neuroscience revea... Read More about The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing.

Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue (2014)
Journal Article
Love, S., Chalmers, K., Ince, P., Esiri, M., Attems, J., Jellinger, K., …Kehoe, P. G. (2014). Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. American Journal of Neurodegenerative Disease, 3(1), 19-32

In a collaboration involving 11 groups with research interests in cerebral amyloid angiopathy (CAA), we used a two-stage process to develop and in turn validate a new consensus protocol and scoring scheme for the assessment of CAA and associated vasc... Read More about Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue.

Assessing environmental features related to mental health: A reliability study of visual streetscape images (2014)
Journal Article
Wu, Y. T., Nash, P., Barnes, L. E., Minett, T., Matthews, F. E., Jones, A., & Brayne, C. (2014). Assessing environmental features related to mental health: A reliability study of visual streetscape images. BMC public health, 14(1), https://doi.org/10.1186/1471-2458-14-1094

Background: An association between depressive symptoms and features of built environment has been reported in the literature. A remaining research challenge is the development of methods to efficiently capture pertinent environmental features in rele... Read More about Assessing environmental features related to mental health: A reliability study of visual streetscape images.

Dementia: Time trends and policy responses (2014)
Journal Article
Wu, Y. T., Matthews, F. E., & Brayne, C. (2014). Dementia: Time trends and policy responses. Maturitas, 79(2), 191-195. https://doi.org/10.1016/j.maturitas.2014.06.020

In recent years, dementia has been considered a public health priority and become a topic of major political interest. Recent reviews and studies have reported with varying degrees of alarm an impending and existing "dementia epidemic" with increasin... Read More about Dementia: Time trends and policy responses.