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Perceived and objective availability of green and blue spaces and quality of life in people with dementia: results from the IDEAL programme (2021)
Journal Article
Wu, Y. T., Clare, L., Jones, I. R., Nelis, S. M., Quinn, C., Martyr, A., …Matthews, F. E. (2021). Perceived and objective availability of green and blue spaces and quality of life in people with dementia: results from the IDEAL programme. Social Psychiatry and Psychiatric Epidemiology, 56(9), 1601-1610. https://doi.org/10.1007/s00127-021-02030-y

Purpose: The aim of this study was to investigate the associations between quality of life and both perceived and objective availability of local green and blue spaces in people with dementia, including potential variation across rural/urban settings... Read More about Perceived and objective availability of green and blue spaces and quality of life in people with dementia: results from the IDEAL programme.

Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia (2021)
Journal Article
Dodds, R. M., Murray, J. C., Granic, A., Hurst, C., Uwimpuhwe, G., Richardson, S., Brayne, C., Matthews, F. E., Sayer, A. A., Arthur, A., Baldwin, C., Barnes, L. E., Comas-Herrera, A., Dening, T., Forster, G., Harrison, S., Ince, P. G., Jagger, C., McKeith, I. G., Parry, B., …Woods, B. (2021). Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia. Journal of Cachexia, Sarcopenia and Muscle, 12(2), 308-318. https://doi.org/10.1002/jcsm.12660

Background: Poor performance in the 5-chair stand test (5-CST) indicates reduced lower limb muscle strength. The 5-CST has been recommended for use in the initial assessment of sarcopenia, the accelerated loss of muscle strength and mass. In order to... Read More about Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia.

Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II (2021)
Journal Article
Bennett, H. Q., Kingston, A., Spiers, G., Robinson, L., Corner, L., Bambra, C., …Jagger, C. (2021). Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II. International Journal of Epidemiology, 50(3), 841-851. https://doi.org/10.1093/ije/dyaa271

Background: Despite increasing life expectancy (LE), cross-sectional data show widening inequalities in disability-free LE (DFLE) by socioeconomic status (SES) in many countries. We use longitudinal data to better understand trends in DFLE and years... Read More about Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II.

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain (2021)
Journal Article
Bury, J. J., Chambers, A., Heath, P. R., Ince, P. G., Shaw, P. J., Matthews, F. E., …Wharton, S. B. (2021). Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9(1), Article 5. https://doi.org/10.1186/s40478-020-01109-y

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this s... Read More about Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.

Dementia in the older population is associated with neocortex content of serum amyloid P component (2021)
Journal Article
Ellmerich, S., Taylor, G. W., Richardson, C. D., Minett, T., Schmidt, A. F., Brayne, C., Matthews, F. E., Ince, P. G., Wharton, S. B., & Pepys, M. B. (2021). Dementia in the older population is associated with neocortex content of serum amyloid P component. Brain Communications, 3(4), Article fcab225. https://doi.org/10.1093/braincomms/fcab225

Despite many reported associations, the direct cause of neurodegeneration responsible for cognitive loss in Alzheimer's disease and some other common dementias is not known. The normal human plasma protein, serum amyloid P component, a constituent of... Read More about Dementia in the older population is associated with neocortex content of serum amyloid P component.

Current and future prevalence estimates of mild cognitive impairment, dementia, and its subtypes in a population-based sample of people 70 years and older in Norway: The HUNT study (2021)
Journal Article
Gjøra, L., Strand, B. H., Bergh, S., Borza, T., Brækhus, A., Engedal, K., Johannessen, A., Kvello-Alme, M., Krokstad, S., Livingston, G., Matthews, F. E., Myrstad, C., Skjellegrind, H., Thingstad, P., Aakhus, E., Aam, S., & Selbæk, G. (2021). Current and future prevalence estimates of mild cognitive impairment, dementia, and its subtypes in a population-based sample of people 70 years and older in Norway: The HUNT study. Journal of Alzheimer's Disease, 79(3), 1213-1226. https://doi.org/10.3233/JAD-201275

Background: Having accurate, up-to-date information on the epidemiology of mild cognitive impairment (MCI) and dementia is imperative. Objective: To determine the prevalence of MCI and dementia in Norway using data from a large population-based study... Read More about Current and future prevalence estimates of mild cognitive impairment, dementia, and its subtypes in a population-based sample of people 70 years and older in Norway: The HUNT study.

Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies (2020)
Journal Article
Waller, R., Narramore, R., Simpson, J. E., Heath, P. R., Verma, N., Tinsley, M., Barnes, J. R., Haris, H. T., Henderson, F. E., Matthews, F. E., Richardson, C. D., Brayne, C., Ince, P. G., Kalaria, R. N., & Wharton, S. B. (2021). Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies. Brain Pathology, 31(3), Article e12928. https://doi.org/10.1111/bpa.12928

White matter lesions (WML) are common in the ageing brain, often arising in a field effect of diffuse white matter abnormality. Although WML are associated with cerebral small vessel disease (SVD) and Alzheimer’s disease (AD), their cause and pathoge... Read More about Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies.

Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study (2020)
Journal Article
Röhr, S., Pabst, A., Riedel-Heller, S. G., Jessen, F., Turana, Y., Handajani, Y. S., Brayne, C., Matthews, F. E., Stephan, B. C., Lipton, R. B., Katz, M. J., Wang, C., Guerchet, M., Preux, P. M., Mbelesso, P., Ritchie, K., Ancelin, M. L., Carrière, I., Guaita, A., Davin, A., …Sachdev, P. S. (2020). Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimer's Research and Therapy, 12(1), Article 167. https://doi.org/10.1186/s13195-020-00734-y

Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across internation... Read More about Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study.

Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies? (2020)
Journal Article
Barker, R. O., Hanratty, B., Kingston, A., Ramsay, S. E., & Matthews, F. E. (2021). Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies?. Age and ageing, 50(3), 921-927. https://doi.org/10.1093/ageing/afaa227

Background: Care home residents have complex care and support needs. There is a perception that the needs of residents have increased, but the evidence is limited. We investigated changes in health and functioning of care home residents over two deca... Read More about Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies?.

Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response (2020)
Journal Article
Fadul, M. M., Heath, P. R., Cooper-Knock, J., Kurz, J. M., Al-Azzawi, H. A., Ali, Z., Smith, T., Matthews, F. E., Brayne, C., Wharton, S. B., & Simpson, J. E. (2020). Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21(21), Article 7924. https://doi.org/10.3390/ijms21217924

White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular lesions (PVL, n = 7) and radiologically-normal-appearing (control) periventricular white matter... Read More about Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response.

Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study (2020)
Journal Article
Hamilton, C. A., Matthews, F. E., Donaghy, P. C., Taylor, J. P., O'Brien, J. T., Barnett, N., Olsen, K., Lloyd, J., Petrides, G., McKeith, I. G., & Thomas, A. J. (2021). Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study. American Journal of Geriatric Psychiatry, 29(3), 272-284. https://doi.org/10.1016/j.jagp.2020.07.018

Objective: We explored whether the mild cognitive impairment (MCI) stages of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) differ in their cognitive profiles, and longitudinal progression. Design: A prospective, longitudinal design was u... Read More about Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study.

Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort (2020)
Journal Article
Chambers, A., Bury, J. J., Minett, T., Richardson, C. D., Brayne, C., Ince, P. G., Shaw, P. J., Garwood, C. J., Heath, P. R., Simpson, J. E., Matthews, F. E., & Wharton, S. B. (2020). Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort. Journal of Neuropathology & Experimental Neurology, 79(9), 950-958. https://doi.org/10.1093/JNEN/NLAA064

Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of macromolecules results in formation of advanced glycation end-products (AGEs). We determined the variation in AGE formation in brains from the Cognitive Function and A... Read More about Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort.

Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia (2020)
Journal Article
Zheng, L., Matthews, F. E., & Anstey, K. J. (2021). Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia. Age and ageing, 50(1), 169-175. https://doi.org/10.1093/ageing/afaa111

Background: Cognitive health expectancy estimates the proportion of the lifespan that is lived in good cognitive health at the population level. A number of cardiovascular diseases have been identified to be risk factors for cognitive decline and dem... Read More about Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia.

Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II (2020)
Journal Article
Grossi, C. M., Richardson, K., Savva, G. M., Fox, C., Arthur, A., Loke, Y. K., Steel, N., Brayne, C., Matthews, F. E., Robinson, L., Myint, P. K., & Maidment, I. D. (2020). Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II. BMC Geriatrics, 20(1), Article 267. https://doi.org/10.1186/s12877-020-01657-x

Background: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in England's older populatio... Read More about Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II.

Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., Zammit, A., Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Archives of Gerontology and Geriatrics, 91, Article 104112. https://doi.org/10.1016/j.archger.2020.104112

Background: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4). Methods: Parti... Read More about Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment.

Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium (2020)
Journal Article
Wolters, F. J., Chibnik, L. B., Waziry, R., Anderson, R., Berr, C., Beiser, A., Bis, J. C., Blacker, D., Bos, D., Brayne, C., Dartigues, J. F., Darweesh, S. K., Davis-Plourde, K. L., De Wolf, F., Debette, S., Dufouil, C., Fornage, M., Goudsmit, J., Grasset, L., Gudnason, V., …Hofman, A. (2020). Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology, 95(5), E519-E531. https://doi.org/10.1212/WNL.0000000000010022

Objective To determine changes in the incidence of dementia between 1988 and 2015.MethodsThis analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Al... Read More about Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.

Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis (2020)
Journal Article
Pieper, N. T., Grossi, C. M., Chan, W. Y., Loke, Y. K., Savva, G. M., Haroulis, C., Steel, N., Fox, C., Maidment, I. D., Arthur, A. J., Myint, P. K., Smith, T. O., Robinson, L., Matthews, F. E., Brayne, C., & Richardson, K. (2020). Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis. Age and ageing, 49(6), 939-947. https://doi.org/10.1093/ageing/afaa090

Background: the long-term effect of the use of drugs with anticholinergic activity on cognitive function remains unclear. Methods: we conducted a systematic review and meta-analysis of the relationship between anticholinergic drugs and risk of dement... Read More about Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis.

The COVID-19 pandemic and health inequalities (2020)
Journal Article
Bambra, C., Riordan, R., Ford, J., & Matthews, F. (2020). The COVID-19 pandemic and health inequalities. Journal of Epidemiology and Community Health, 74(11), 964-968. https://doi.org/10.1136/jech-2020-214401

This essay examines the implications of the COVID-19 pandemic for health inequalities. It outlines historical and contemporary evidence of inequalities in pandemics - drawing on international research into the Spanish influenza pandemic of 1918, the... Read More about The COVID-19 pandemic and health inequalities.

APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., CuilingWang, Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline. The journals of gerontology. Series A, Biological sciences and medical sciences, 75(10), 1863-1873. https://doi.org/10.1093/gerona/glaa116

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals ag... Read More about APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline.