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All Outputs (334)

Blinding trachoma in postconflict southern Sudan (2006)
Journal Article
Ngondi, J., Ole-Sempele, F., Onsarigo, A., Matende, I., Baba, S., Reacher, M., …Emerson, P. (2006). Blinding trachoma in postconflict southern Sudan. PLoS Medicine, 3(12), 2424-2430. https://doi.org/10.1371/journal.pmed.0030478

Background: Trachoma is a leading cause of preventable blindness. Reports from eye surgery camps and anecdotal data indicated that blinding trachoma is a serious cause of visual impairment in Mankien payam (district) of southern Sudan. We conducted t... Read More about Blinding trachoma in postconflict southern Sudan.

Self-rated health status as a predictor of death, functional and cognitive impairment: A longitudinal cohort study (2006)
Journal Article
Bond, J., Dickinson, H. O., Matthews, F., Jagger, C., & Brayne, C. (2006). Self-rated health status as a predictor of death, functional and cognitive impairment: A longitudinal cohort study. European Journal of Ageing, 3(4), 193-206. https://doi.org/10.1007/s10433-006-0039-8

Understanding the prognostic capacity of a simple measure of self-rated health (SRH) by older people becomes increasingly important as the population ages. SRH has been shown to predict survival, functional status and service use. The relationship wi... Read More about Self-rated health status as a predictor of death, functional and cognitive impairment: A longitudinal cohort study.

Dementia before death in ageing societies - The promise of prevention and the reality (2006)
Journal Article
Brayne, C., Gao, L., Dewey, M., & Matthews, F. E. (2006). Dementia before death in ageing societies - The promise of prevention and the reality. PLoS Medicine, 3(10), 1922-1930. https://doi.org/10.1371/journal.pmed.0030397

Background: Dementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions. Given population increases in longevity it is important to understand not only risk and... Read More about Dementia before death in ageing societies - The promise of prevention and the reality.

The frequency and validity of self-reported diagnosis of Parkinson's disease in the UK elderly: MRC CFAS cohort (2006)
Journal Article
Foltynie, T., Matthews, F. E., Ishihara, L., & Brayne, C. (2006). The frequency and validity of self-reported diagnosis of Parkinson's disease in the UK elderly: MRC CFAS cohort. BMC Neurology, 6, https://doi.org/10.1186/1471-2377-6-29

Background: Estimates of the incidence and prevalence of chronic diseases can be made using established cohort studies but these estimates may have lower reliability if based purely on self-reported diagnosis. Methods: The MRC Cognitive Function & Ag... Read More about The frequency and validity of self-reported diagnosis of Parkinson's disease in the UK elderly: MRC CFAS cohort.

Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study (2006)
Journal Article
Ngondi, J., Onsarigo, A., Matthews, F., Reacher, M., Brayne, C., Baba, S., …Emerson, P. M. (2006). Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study. Lancet, 368(9535), 589-595. https://doi.org/10.1016/S0140-6736%2806%2969202-7

Background: A trachoma control programme was started in southern Sudan in 2001. We did a 3-year evaluation to quantify uptake of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) interventions, and to assess the prevalence of... Read More about Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study.

An investigation of whether factors associated with short-term attrition change or persist over ten years: Data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2006)
Journal Article
Matthews, F. E., Chatfield, M., & Brayne, C. (2006). An investigation of whether factors associated with short-term attrition change or persist over ten years: Data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC public health, 6, https://doi.org/10.1186/1471-2458-6-185

Background: Factors associated with the loss of participants in long-term longitudinal studies of ageing, due to refusal or moves, have been discussed less than those with short term follow-up. Methods: In a population-based study of cognition and ag... Read More about An investigation of whether factors associated with short-term attrition change or persist over ten years: Data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

White matter lesions in an unselected cohort of the elderly: Molecular pathology suggests origin from chronic hypoperfusion injury (2006)
Journal Article
Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., …Ince, P. G. (2006). White matter lesions in an unselected cohort of the elderly: Molecular pathology suggests origin from chronic hypoperfusion injury. Stroke, 37(6), 1391-1398. https://doi.org/10.1161/01.STR.0000221308.94473.14

BACKGROUND AND PURPOSE - "Incidental" MRI white matter (WM) lesions, comprising periventricular lesions (PVLs) and deep subcortical lesions (DSCLs), are common in the aging brain. Direct evidence of ischemia associated with incidental WM lesions (WML... Read More about White matter lesions in an unselected cohort of the elderly: Molecular pathology suggests origin from chronic hypoperfusion injury.

Regional differences in multidimensional aspects of health: Findings from the MRC cognitive function and ageing study (2006)
Journal Article
Matthews, F. E., Miller, L. L., Brayne, C., & Jagger, C. (2006). Regional differences in multidimensional aspects of health: Findings from the MRC cognitive function and ageing study. BMC public health, 6, https://doi.org/10.1186/1471-2458-6-90

Background: Differences in mortality and health experience across regions are well recognised and UK government policy aims to address this inequality. Methods combining life expectancy and health have concentrated on specific areas, such as self-per... Read More about Regional differences in multidimensional aspects of health: Findings from the MRC cognitive function and ageing study.

Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study (2006)
Journal Article
Yip, A. G., Brayne, C., & Matthews, F. E. (2006). Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. Age and ageing, 35(2), 154-160. https://doi.org/10.1093/ageing/afj030

Objective: To investigate a number of prospectively collected factors (sociodemographic, medical and behavioural) and their association with incident dementia in a population-based cohort. Design: Nested case-control analysis (at 2 and 6 years) of a... Read More about Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study.

Prevalence and causes of blindness and low vision in southern Sudan (2006)
Journal Article
Ngondi, J., Ole-Sempele, F., Onsarigo, A., Matende, I., Baba, S., Reacher, M., …Emerson, P. M. (2006). Prevalence and causes of blindness and low vision in southern Sudan. PLoS Medicine, 3(12), 2416-2423. https://doi.org/10.1371/journal.pmed.0030477

Background: Blindness and low vision are thought to be common in southern Sudan. However, the magnitude and geographical distribution are largely unknown. We aimed to estimate the prevalence of blindness and low vision, identify the main causes of bl... Read More about Prevalence and causes of blindness and low vision in southern Sudan.

Depression in the elderly: Pathological study of raphe and locus ceruleus (2005)
Journal Article
Syed, A., Chatfield, M., Matthews, F., Harrison, P., Brayne, C., & Esiri, M. M. (2005). Depression in the elderly: Pathological study of raphe and locus ceruleus. Neuropathology and Applied Neurobiology, 31(4), 405-413. https://doi.org/10.1111/j.1365-2990.2005.00662.x

Depressive symptoms in the elderly are common and disabling and constitute a risk factor for the development of Alzheimer's disease (AD). One hypothesis worth exploring is that depression in the elderly is related to development of AD pathology at su... Read More about Depression in the elderly: Pathological study of raphe and locus ceruleus.

Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination (2005)
Journal Article
Huppert, F. A., Cabelli, S. T., & Matthews, F. E. (2005). Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination. BMC Geriatrics, 5, https://doi.org/10.1186/1471-2318-5-7

Background: Despite the MMSE's known flaws, it is still used extensively as both a screening instrument for dementia and a population measure of cognitive ability. The aim of this paper is to provide data on the distribution of MMSE scores in a repre... Read More about Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination.

Brain donation for research: consent and re-consent post Alder Hey. (2005)
Journal Article
Barnes, L., Matthews, F. E., Barber, B., Davies, L., Lloyd, D., Brayne, C., & Parry, B. (2005). Brain donation for research: consent and re-consent post Alder Hey

Background: Recent scandals relating to the unconsented retention and use of human organs in the UK have led to widespread changes to governance and ethical frameworks for research throughout England and Wales. Ethics committees now ask for proof of... Read More about Brain donation for research: consent and re-consent post Alder Hey..

The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study (2005)
Journal Article
Matthews, F., Brayne, C., Arie, T., Bond, J., Copeland, J., Day, N., …Parker, C. (2005). The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study. PLoS Medicine, 2(8), 0753-0763. https://doi.org/10.1371/journal.pmed.0020193

Background: Although incidence of dementia is known to vary between nations, variation within country has not been explored because most incidence studies are single site or have insufficient numbers to compare sites. Few countries have conducted mul... Read More about The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study.

Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression (2005)
Journal Article
Brayne, C., Gao, L., & Matthews, F. (2005). Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression. Neurobiology of Aging, 26(SUPPL.), 6-10. https://doi.org/10.1016/j.neurobiolaging.2005.09.030

There are many challenges facing epidemiologists wishing to investigate relationships between physical activity, obesity, diabetes, dementia and depression, all of which are complex fields in their own right. There is a large literature investigating... Read More about Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression.

Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study (2005)
Journal Article
Spiers, N. A., Matthews, R. J., Jagger, C., Matthews, F. E., Boult, C., Robinson, T. G., & Brayne, C. (2005). Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study. The journals of gerontology. Series A, Biological sciences and medical sciences, 60(2), 248-254. https://doi.org/10.1093/gerona/60.2.248

Background. This paper reports the association between self-reported diseases and impairments and 2-year onset of disability in a prospective study of people aged 65 years or older in five urban and rural centers in England and Wales (Medical Researc... Read More about Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study.

A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies (2005)
Journal Article
Chatfield, M. D., Brayne, C. E., & Matthews, F. E. (2005). A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies. Journal of clinical epidemiology, 58(1), 13-19. https://doi.org/10.1016/j.jclinepi.2004.05.006

Longitudinal studies of the elderly are complicated by the loss of individuals between waves due to death or other dropout mechanisms. Factors that affect dropout may well be similar from one study to another. This article systematically reviews all... Read More about A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.

Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain (2004)
Journal Article
Fernando, M. S., O'Brien, J. T., Perry, R. H., English, P., Forster, G., McMeekin, W., …Ince, P. G. (2004). Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. Neuropathology and Applied Neurobiology, 30(4), 385-395. https://doi.org/10.1111/j.1365-2990.2004.00550.x

White matter lesions (WML) on magnetic resonance imaging (MRI) brain scans are associated with ageing. They are unrelated to specific disorders, and their impact on cognitive and other brain functions is poorly characterized. Pathological studies oft... Read More about Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain.