All Outputs (6)

Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial (2024)
Journal Article
Yu, Y. L., Siwy, J., An, D. W., González, A., Hansen, T. W., Latosinska, A., …Collier, T. (in press). Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial. Heart, https://doi.org/10.1136/heartjnl-2023-323796

Objective Heart failure (HF) is characterised by collagen deposition. Urinary proteomic profiling (UPP) followed by peptide sequencing identifies parental proteins, for over 70% derived from collagens. This study aimed to refine understanding of the... Read More about Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial.

Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study (2024)
Journal Article
Cuthbert, J. J., Soyiri, I., Lomax, S. J., Turgoose, J., Fuat, A., Cohen, J., & Clark, A. L. (2024). Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study. Heart, 110(12), Article 323577. https://doi.org/10.1136/heartjnl-2023-323577

Background Loop diuretics are commonly prescribed in the community, not always to patients with a recorded diagnosis of heart failure (HF). The rate of HF events in patients prescribed loop diuretics without a diagnosis of HF is unknown. Methods... Read More about Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study.

Hospital admissions in the last year of life of patients with heart failure (2024)
Journal Article
AI Abel, A., Samuel, N. A., Cuthbert, J. J., Brown, O. I., Pellicori, P., Kazmi, S., …Clark, A. L. (2024). Hospital admissions in the last year of life of patients with heart failure. European Heart Journal - Quality of Care and Clinical Outcomes, 10(2), 168-175. https://doi.org/10.1093/ehjqcco/qcad047

Aim To explore the frequency, causes, and pattern of hospitalisation for patients with chronic heart failure (HF) in the 12 months preceding death. We also investigated cause of death. Methods Patients referred to a secondary care HF clinic were rout... Read More about Hospital admissions in the last year of life of patients with heart failure.

Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy (2024)
Journal Article
Cuthbert, J., Clark, A., & Cleland, J. (2024). Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy. Current Heart Failure Reports, https://doi.org/10.1007/s11897-024-00644-2

Purpose of Review Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion loop... Read More about Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy.

Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics (2024)
Journal Article
Cuthbert, J. J., & Clark, A. L. (2024). Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics. Current Heart Failure Reports, 21(2), 101-114. https://doi.org/10.1007/s11897-024-00643-3

Purpose of Review: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion—loop... Read More about Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics.

Medicines optimization prior to discharge in patients admitted to hospital with heart failure (2024)
Journal Article
Cuthbert, J. J., Brown, O. I., Pellicori, P., Dobbs, K., Bulemfu, J., Kazmi, S., …Clark, A. L. (2024). Medicines optimization prior to discharge in patients admitted to hospital with heart failure. ESC Heart Failure, 11(2), 950-961. https://doi.org/10.1002/ehf2.14638

Aims: Approximately half of patients with heart failure and a reduced ejection fraction (HeFREF) are discharged from hospital on triple therapy [angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), beta-blockers... Read More about Medicines optimization prior to discharge in patients admitted to hospital with heart failure.