Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep and EEG power spectra in a model of situational insomnia
(2012)
Journal Article
Bettica, P., Squassante, L., Groeger, J. A., Gennery, B., Winsky-Sommerer, R., & Dijk, D.-J. (2012). Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep and EEG power spectra in a model of situational insomnia. Neuropsychopharmacology, 37(5), 1224-1233. https://doi.org/10.1038/npp.2011.310
Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single... Read More about Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep and EEG power spectra in a model of situational insomnia.