All Outputs (5)

A theoretical analysis of the scale separation in a model to predict solid tumour growth (2022)
Journal Article
de Melo Quintela, B., Hervas-Raluy, S., Garcia-Aznar, J. M., Walker, D., Wertheim, K. Y., & Viceconti, M. (2022). A theoretical analysis of the scale separation in a model to predict solid tumour growth. Journal of Theoretical Biology, 547, Article 111173. https://doi.org/10.1016/j.jtbi.2022.111173

Solid tumour growth depends on a host of factors which affect the cell life cycle and extracellular matrix vascularization that leads to a favourable environment. The whole solid tumour can either grow or wither in response to the action of the immun... Read More about A theoretical analysis of the scale separation in a model to predict solid tumour growth.

A multi-approach and multi-scale platform to model CD4+ T cells responding to infections (2021)
Journal Article
Wertheim, K. Y., Puniya, B. L., La Fleur, A., Shah, A. R., Barberis, M., & Helikar, T. (2021). A multi-approach and multi-scale platform to model CD4+ T cells responding to infections. PLoS Computational Biology, 17(8), Article e1009209. https://doi.org/10.1371/journal.pcbi.1009209

Immune responses rely on a complex adaptive system in which the body and infections interact at multiple scales and in different compartments. We developed a modular model of CD4+ T cells, which uses four modeling approaches to integrate processes at... Read More about A multi-approach and multi-scale platform to model CD4+ T cells responding to infections.

PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers (2020)
Journal Article
Martí-Bonmatí, L., Alberich-Bayarri, Á., Ladenstein, R., Blanquer, I., Segrelles, J. D., Cerdá-Alberich, L., …Neri, E. (2020). PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers. European Radiology Experimental, 4(1), https://doi.org/10.1186/s41747-020-00150-9

PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consor... Read More about PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers.

Can VEGFC Form Turing Patterns in the Zebrafish Embryo? (2019)
Journal Article
Wertheim, K. Y., & Roose, T. (2019). Can VEGFC Form Turing Patterns in the Zebrafish Embryo?. Bulletin of Mathematical Biology, 81(4), 1201-1237. https://doi.org/10.1007/s11538-018-00560-2

This paper is concerned with a late stage of lymphangiogenesis in the trunk of the zebrafish embryo. At 48 hours post-fertilisation (HPF), a pool of parachordal lymphangioblasts (PLs) lies in the horizontal myoseptum. Between 48 and 168 HPF, the PLs... Read More about Can VEGFC Form Turing Patterns in the Zebrafish Embryo?.

A Mathematical Model of Lymphangiogenesis in a Zebrafish Embryo (2017)
Journal Article
Wertheim, K. Y., & Roose, T. (2017). A Mathematical Model of Lymphangiogenesis in a Zebrafish Embryo. Bulletin of Mathematical Biology, 79(4), 693-737. https://doi.org/10.1007/s11538-017-0248-7

The lymphatic system of a vertebrate is important in health and diseases. We propose a novel mathematical model to elucidate the lymphangiogenic processes in zebrafish embryos. Specifically, we are interested in the period when lymphatic endothelial... Read More about A Mathematical Model of Lymphangiogenesis in a Zebrafish Embryo.