All Outputs (2)

A multiscale orchestrated computational framework to reveal emergent phenomena in neuroblastoma (2023)
Journal Article
Borau, C., Wertheim, K., Hervas-Raluy, S., Sainz-DeMena, D., Walker, D., Chisholm, R., …García-Aznar, J. (2023). A multiscale orchestrated computational framework to reveal emergent phenomena in neuroblastoma. Computer Methods and Programs in Biomedicine, 241, Article 107742. https://doi.org/10.1016/j.cmpb.2023.107742

Neuroblastoma is a complex and aggressive type of cancer that affects children. Current treatments involve a combination of surgery, chemotherapy, radiotherapy, and stem cell transplantation. However, treatment outcomes vary due to the heterogeneous... Read More about A multiscale orchestrated computational framework to reveal emergent phenomena in neuroblastoma.

Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma (2023)
Journal Article
Italia, M., Wertheim, K. Y., Taschner-Mandl, S., Walker, D., & Dercole, F. (2023). Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma. Cancers, 15(7), Article 1986. https://doi.org/10.3390/cancers15071986

Neuroblastoma is the most common extra-cranial solid tumour in children. Despite multi-modal therapy, over half of the high-risk patients will succumb. One contributing factor is the one-size-fits-all nature of multi-modal therapy. For example, durin... Read More about Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma.