All Outputs (3)

Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins (2013)
Journal Article
Alzahrani, E., & Welham, K. (2014). Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins. Analytical Methods, 6(2), 558-568. https://doi.org/10.1039/c3ay41442f

Protein identification by mass spectrometry forms the cornerstone of proteomics. Commonly, the identification of proteins is based on digestion of proteins into peptides using proteolytic enzymes. Cleavage of the disulphide bonds in proteins before e... Read More about Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins.

Preconcentration of milk proteins using octadecylated monolithic silica microchip (2013)
Journal Article
Alzahrani, E., & Welham, K. (2013). Preconcentration of milk proteins using octadecylated monolithic silica microchip. Analytica Chimica Acta, 798, 40-47. https://doi.org/10.1016/j.aca.2013.08.035

Sample preparation is a bottleneck in systems for chemical analysis and it is a required step in order to remove interference and preconcentrate the target analytes. Much research in recent years has focused on porous monolithic materials since they... Read More about Preconcentration of milk proteins using octadecylated monolithic silica microchip.

Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen (2013)
Journal Article
Kashuba, E., Eagle, G. L., Bailey, J., Evans, P., Welham, K. J., Allsup, D., & Cawkwell, L. (2013). Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen. Journal of Proteomics, 91, 478-485. https://doi.org/10.1016/j.jprot.2013.08.002

CLL is an incurable disease with variable prognosis. The hyper reactivity of the B-cell receptor (BCR) to unknown antigen ligation plays a pivotal role in CLL-cell survival. We aimed to investigate the BCR signalling pathway using proteomics to ident... Read More about Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen.