All Outputs (2)

The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis (2013)
Journal Article
Nikitenko, L. L., Leek, R., Henderson, S., Pillay, N., Turley, H., Generali, D., Gunningham, S., Morrin, H. R., Pellagatti, A., Rees, M. C., Harris, A. L., & Fox, S. B. (2013). The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. Clinical cancer research : an official journal of the American Association for Cancer Research, 19(20), 5740-5748. https://doi.org/10.1158/1078-0432.CCR-13-1712

Purpose: The G-protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers. We therefore... Read More about The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema (2013)
Journal Article
Nikitenko, L. L., Shimosawa, T., Henderson, S., Mäkinen, T., Shimosawa, H., Qureshi, U., Pedley, R. B., Rees, M. C., Fujita, T., & Boshoff, C. (2013). Adrenomedullin haploinsufficiency predisposes to secondary lymphedema. Journal of Investigative Dermatology, 133(7), 1768-1776. https://doi.org/10.1038/jid.2013.47

Secondary lymphedema is a debilitating condition, and genetic factors predisposing to its development remain largely unknown. Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the Adm gene (adrenome... Read More about Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.