All Outputs (4)

Practical considerations of dissolved oxygen levels for platelet function under hypoxia (2021)
Journal Article
Kusanto, B., Gordon, A., Naylor-Adamson, L., Atkinson, L., Coupland, C., Booth, Z., …Arman, M. (2021). Practical considerations of dissolved oxygen levels for platelet function under hypoxia. International Journal of Molecular Sciences, 22(24), Article 13223. https://doi.org/10.3390/ijms222413223

Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing bloo... Read More about Practical considerations of dissolved oxygen levels for platelet function under hypoxia.

Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon? (2021)
Journal Article
Atkinson, L., Martin, F., & Sturmey, R. G. (2021). Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?. Human Reproduction, 36(7), 1737-1750. https://doi.org/10.1093/humrep/deab106

The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related declines in fertility or in pathological conditions such as premature ovarian failure. The concept of ovarian rejuvenation was invigorated by the indication... Read More about Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?.

Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi (2018)
Journal Article
Atkinson, L., Yusuf, M. Z., Aburima, A., Ahmed, Y., Thomas, S. G., Naseem, K. M., & Calaminus, S. D. J. (2018). Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi. Scientific reports, 8(1), Article ARTN 3032. https://doi.org/10.1038/s41598-018-21167-6

© 2018 The Author(s). Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised that Nitric oxide (NO), a platelet inhibitor, can modulate the actin cytosk... Read More about Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi.

Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability (2017)
Journal Article
Yusuf, M. Z., Raslan, Z., Atkinson, L., Aburima, A., Thomas, S. G., Naseem, K. M., & Calaminus, S. D. (2017). Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability. Scientific reports, 7(1), Article ARTN 5582. https://doi.org/10.1038/s41598-017-05817-9

Prostacyclin (PGI2) modulates platelet activation to regulate haemostasis. Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation. It was hypothesised that PGI2 could reverse platelet... Read More about Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability.