All Outputs (9)

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations. The Cochrane database of systematic reviews, 2021(12), CD013839. https://doi.org/10.1002/14651858.CD013839.pub2

BACKGROUND: Diabetes and vascular disease are the leading causes of lower limb amputation. Currently, 463 million adults are living with diabetes, and 202 million with peripheral vascular disease, worldwide. When a lower limb amputation is considered... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations.

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. (2021)
Journal Article
Danopoulos, E., Twiddy, M., West, R., & Rotchell, J. M. (in press). A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. Journal of hazardous materials, Article 127861. https://doi.org/10.1016/j.jhazmat.2021.127861

Humans are exposed to microplastics (MPs) daily via ingestion and inhalation. It is not known whether this results in adverse health effects and, if so, at what levels of exposure. Without epidemiological studies, human cell in vitro MP toxicological... Read More about A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells..

The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience (2021)
Journal Article
Chen, H., Twiddy, M., Jones, L., & Johnson, M. J. (2021). The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience. European Journal of Cancer Care, 30(6), Article e13503. https://doi.org/10.1111/ecc.13503

Objective: The objective of this study is to explore the specific information and communication needs of men affected by prostate cancer to inform the development of educational materials for clinicians. Methods: This is a qualitative descriptive stu... Read More about The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience.

A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol (2021)
Journal Article
Twiddy, M., Hazara, A., Bhandari, S., & Allgar, V. (in press). A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol. Clinical and Experimental Nephrology, https://doi.org/10.1007/s10157-021-02072-1

Background: Incremental haemodialysis/haemodiafiltration (HD) may help reduce early mortality rates in patients starting HD. This mixed-method feasibility study aims to test the acceptability, tolerance and safety of a novel incremental HD regime, an... Read More about A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol.

The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review (2021)
Journal Article
Simms, M., Parker, P., Rigby, A., Whybrow, P., & Twiddy, M. (in press). The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review. Ultrasound, https://doi.org/10.1177/1742271X21995212

Background: The use of multiparametric magnetic resonance imaging (mpMRI) within active surveillance of prostate cancer programmes is identified by the UK National Institute for Health and Care Excellence (NICE guideline NG 131 2019) as having a role... Read More about The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review.

The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres (2021)
Journal Article
Burton, W., Sahota, P., Twiddy, M., Brown, J., & Bryant, M. (in press). The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres. Prevention Science, https://doi.org/10.1007/s11121-021-01205-y

Background
Poor participant engagement threatens the potential impact and cost effectiveness of public health programmes preventing meaningful evaluation and wider application. Although barriers and levers to engagement with public health programmes... Read More about The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres.

Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study (2021)
Journal Article
Brown, J. M., Croft, J., Poad, H., Bell, R., Collinson, M., Gordon, K., Dooldeniya, M., Conroy, S., Catto, J. W., Noon, A. P., Simms, M., Chahal, R., Jain, S., Koenig, P., Johnson, M., Twiddy, M., & Goodwin, L. (2021). Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study. Journal of Clinical Oncology, 39(3), 202-214. https://doi.org/10.1200/JCO.20.01665

PURPOSE: High-grade nonmuscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease. Treatments include intravesical maintenance Bacillus Calmette-Guerin (mBCG) and radical cystectomy (RC). We wanted to understand whether a randomized trial co... Read More about Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol) (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol). Cochrane Database of Systematic Reviews, 2021(1), Article CD013839. https://doi.org/10.1002/14651858.CD013839

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of through-knee amputation compared to above-knee amputation on clinical and rehabilitation outcomes and complication rates in... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol).

Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers (2021)
Journal Article
Johnson, M. J., Huang, C., Chen, H., Jones, L., & Twiddy, M. (2021). Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003438

Objectives: Men living with prostate cancer have supportive and palliative needs. However, few studies detail unmet needs (vs quality of life measurement) or include data from those with advanced disease. We aimed to identify unmet needs of people li... Read More about Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers.