Skip to main content

Research Repository

Advanced Search

All Outputs (99)

Assessment of the role of sutures in a lizard skull: a computer modelling study (2009)
Journal Article
Moazen, M., Curtis, N., O'Higgins, P., Jones, M. E., Evans, S. E., & Fagan, M. J. (2009). Assessment of the role of sutures in a lizard skull: a computer modelling study. Proceedings of the Royal Society B: Biological Sciences, 276(1654), 39-46. https://doi.org/10.1098/rspb.2008.0863

Sutures form an integral part of the functioning skull, but their role has long been debated among vertebrate morphologists and palaeontologists. Furthermore, the relationship between typical skull sutures, and those involved in cranial kinesis, is p... Read More about Assessment of the role of sutures in a lizard skull: a computer modelling study.

Masticatory loading and bone adaptation in the supraorbital torus of developing macaques (2008)
Journal Article
Kupczik, K., Dobson, C. A., Crompton, R. H., Phillips, R., Oxnard, C. E., Fagan, M. J., & O'Higgins, P. (2009). Masticatory loading and bone adaptation in the supraorbital torus of developing macaques. American journal of physical anthropology, 139(2), 193-203. https://doi.org/10.1002/ajpa.20972

Research on the evolution and adaptive significance of primate craniofacial morphologies has focused on adult, fully developed individuals. Here, we investigate the possible relationship between the local stress environment arising from masticatory l... Read More about Masticatory loading and bone adaptation in the supraorbital torus of developing macaques.

Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull (2008)
Journal Article
Moazen, M., Curtis, N., Evans, S. E., O’Higgins, P., & Fagan, M. J. (2008). Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull. Journal of anatomy, 213(5), 499-508. https://doi.org/10.1111/j.1469-7580.2008.00980.x

Lizard skulls vary greatly in shape and construction, and radical changes in skull form during evolution have made this an intriguing subject of research. The mechanics of feeding have surely been affected by this change in skull form, but whether th... Read More about Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull.

A new approach to amino acid racemization in enamel: testing of a less destructive sampling methodology (2008)
Journal Article
Griffin, R. C., Moody, H., Penkman, K. E. H., Fagan, M. J., Curtis, N., & Collins, M. J. (2008). A new approach to amino acid racemization in enamel: testing of a less destructive sampling methodology. Journal of Forensic Sciences, 53(4), 910-916. https://doi.org/10.1111/j.1556-4029.2008.00753.x

Aspartic acid racemization has been found to be an accurate measure of age at death for recent forensic material. This paper examines the practicality of using acid etching of the tooth surface to extract amino acids from the enamel for racemization... Read More about A new approach to amino acid racemization in enamel: testing of a less destructive sampling methodology.

Predicting skull loading: applying multibody dynamics analysis to a macaque skull (2008)
Journal Article
Curtis, N., Kupczik, K., O'Higgins, P., Moazen, M., & Fagan, M. (2008). Predicting skull loading: applying multibody dynamics analysis to a macaque skull. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 291(5), 491-501. https://doi.org/10.1002/ar.20689

Evaluating stress and strain fields in anatomical structures is a way to test hypotheses that relate specific features of facial and skeletal morphology to mechanical loading. Engineering techniques such as finite element analysis are now commonly us... Read More about Predicting skull loading: applying multibody dynamics analysis to a macaque skull.

Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii (2008)
Journal Article
Moazen, M., Curtis, N., Evans, S. E., O'Higgins, P., & Fagan, M. J. (2008). Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii. Journal of biomechanics, 41(6), 1274-1280. https://doi.org/10.1016/j.jbiomech.2008.01.012

Lizard skulls vary greatly in their detailed morphology. Theoretical models and practical studies have posited a definite relationship between skull morphology and bite performance, but this can be difficult to demonstrate in vivo. Computer modelling... Read More about Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii.

Accurate quantification of the influence of benthic macro- and meio-fauna on the geometric properties of estuarine muds by micro computer tomography (2007)
Journal Article
Mazik, K., Curtis, N., Fagan, M. J., Taft, S., & Elliott, M. (2008). Accurate quantification of the influence of benthic macro- and meio-fauna on the geometric properties of estuarine muds by micro computer tomography. Journal of experimental marine biology and ecology, 354(2), 192-201. https://doi.org/10.1016/j.jembe.2007.11.006

This paper describes the novel application of high resolution micro computer tomography (microCT) to the quantification of the properties of marine biogenic structures. CT scanning has been used to examine sediments in the past but the resolution of... Read More about Accurate quantification of the influence of benthic macro- and meio-fauna on the geometric properties of estuarine muds by micro computer tomography.

Peak wall stress measurement in elective and acute abdominal aortic aneurysms (2007)
Journal Article
Heng, M. S., Fagan, M. J., Collier, J. W., Desai, G., McCollum, P. T., & Chetter, I. C. (2008). Peak wall stress measurement in elective and acute abdominal aortic aneurysms. Journal of vascular surgery, 47(1), 17-22. https://doi.org/10.1016/j.jvs.2007.09.002

Background: Abdominal aortic aneurysm (AAA) rupture occurs when wall stress exceeds wall strength. Engineering principles suggest that aneurysm diameter is only one aspect of its geometry that influences wall stress. Finite element analysis considers... Read More about Peak wall stress measurement in elective and acute abdominal aortic aneurysms.

Development of a (silent) speech recognition system for patients following laryngectomy (2007)
Journal Article
Fagan, M. J., Ell, S. R., Gilbert, J. M., Sarrazin, E., & Chapman, P. M. (2008). Development of a (silent) speech recognition system for patients following laryngectomy. Medical engineering & physics, 30(4), 419-425. https://doi.org/10.1016/j.medengphy.2007.05.003

Surgical voice restoration post-laryngectomy has a number of limitations and drawbacks. The present gold standard involves the use of a tracheo-oesophageal fistula (TOF) valve to divert air from the lungs into the throat, which vibrates, and from thi... Read More about Development of a (silent) speech recognition system for patients following laryngectomy.

Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models (2006)
Journal Article
Kupczik, K., Dobson, C. A., Fagan, M. J., Crompton, R. H., Oxnard, C. E., & O'Higgins, P. (2007). Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models. Journal of anatomy, 210(1), 41-53. https://doi.org/10.1111/j.1469-7580.2006.00662.x

Crucial to the interpretation of the results of any finite element analysis of a skeletal system is a test of the validity of the results and an assessment of the sensitivity of the model parameters. We have therefore developed finite element models... Read More about Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models.

Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results (2006)
Journal Article
Dobson, C. A., Sisias, G., Phillips, R., Langton, C. M., & Fagan, M. J. (2006). Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 220(3), 481-484. https://doi.org/10.1243/09544119H00405

Stereolithography (STL) models of complex cancellous bone structures have been produced from three-dimensional micro-computed tomography data sets of human cancellous bone histological samples from four skeletal sites. The STL models have been mechan... Read More about Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results.

A Comparative Study of Aortic Wall Stress Using Finite Element Analysis for Ruptured and Non-ruptured Abdominal Aortic Aneurysms*1 (2004)
Journal Article
VENKATASUBRAMANIAM, A., FAGAN, M., MEHTA, T., MYLANKAL, K., RAY, B., KUHAN, G., …MCCOLLUM, P. (2004). A Comparative Study of Aortic Wall Stress Using Finite Element Analysis for Ruptured and Non-ruptured Abdominal Aortic Aneurysms*1. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 28(2), 168-176. https://doi.org/10.1016/S1078-5884%2804%2900178-9

Background. The decision to repair an asymptomatic abdominal aortic aneurysm (AAA) is currently based on diameter (greater than or equal to 5.5 cm) alone. However, aneurysms less than 5.5 cm do rupture while some reach greater than 5.5 cm without rup... Read More about A Comparative Study of Aortic Wall Stress Using Finite Element Analysis for Ruptured and Non-ruptured Abdominal Aortic Aneurysms*1.

A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms (2004)
Journal Article
Venkatasubramaniam, A. K., Fagan, M. J., Mehta, T., Mylankal, K. J., Ray, B., Kuhan, G., …McCollum, P. T. (2004). A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 28(2), 168-176. https://doi.org/10.1016/j.ejvs.2004.03.029

Background. The decision to repair an asymptomatic abdominal aortic aneurysm (AAA) is currently based on diameter (≥5.5 cm) alone. However, aneurysms less than 5.5 cm do rupture while some reach greater than 5.5 cm without rupturing. Hence the need t... Read More about A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms.

Patient-specific spine models. Part 1: Finite element analysis of the lumbar intervertebral disc—a material sensitivity study (2002)
Journal Article
Fagan, M. J., Julian, S., Siddall, D. J., & Mohsen, A. M. (2002). Patient-specific spine models. Part 1: Finite element analysis of the lumbar intervertebral disc—a material sensitivity study. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 216(5), 299-314. https://doi.org/10.1243/09544110260216577

If patient-specific finite element models of the spine could be developed, they would offer enormous opportunities in the diagnosis and management of back problems. Several generic models have been developed in the past, but there has been very littl... Read More about Patient-specific spine models. Part 1: Finite element analysis of the lumbar intervertebral disc—a material sensitivity study.

Algorithms for accurate rapid prototyping replication of cancellous bone voxel maps (2002)
Journal Article
Sisias, G., Phillips, R., Dobson, C., Fagan, M., & Langton, C. (2002). Algorithms for accurate rapid prototyping replication of cancellous bone voxel maps. Rapid Prototyping Journal, 8(1), 6-24. https://doi.org/10.1108/13552540210413266

A set of algorithms has been developed and evaluated for 3D and 21/2D rapid prototyping replication of 3D reconstructions of cancellous bone samples. The algorithms replicate a voxel map without any loss of fidelity, so as to increase the validity of... Read More about Algorithms for accurate rapid prototyping replication of cancellous bone voxel maps.

Smoothing of pixelated finite element models of cancellous bone structures and the effect on the predicted structural properties of the bone (2002)
Journal Article
Dobson, C. A., Sisias, G., Phillips, R., Langton, C. M., & Fagan, M. J. (2002). Smoothing of pixelated finite element models of cancellous bone structures and the effect on the predicted structural properties of the bone. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 216(2), 145-149. https://doi.org/10.1243/0954411021536360

Many areas of biomedical engineering involve the modelling of biological systems, often using data from medical scanning techniques such as computed microtomography (μCT), and the prediction of the mechanical properties of these systems via finite el... Read More about Smoothing of pixelated finite element models of cancellous bone structures and the effect on the predicted structural properties of the bone.

Stochastically simulated assessment of anabolic treatment following varying degrees of cancellous bone resorption (2000)
Journal Article
Langton, C., Haire, T., Ganney, P., Dobson, C., Fagan, M., Sisias, G., & Phillips, R. (2000). Stochastically simulated assessment of anabolic treatment following varying degrees of cancellous bone resorption. Bone, 27(1), 111-118. https://doi.org/10.1016/s8756-3282%2800%2900290-8

The aim of this study was to investigate the recovery in cancellous bone stiffness resulting from anabolic treatment following varying degrees of resorption, using a stochastic simulation applied to a simplistic structure consisting of five vertical... Read More about Stochastically simulated assessment of anabolic treatment following varying degrees of cancellous bone resorption.