Arginine deprivation with pegylated Arginine Deiminase in patients with Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial

Szlosarek, Peter W.; Steele, Jeremy P.; Nolan, Luke; Gilligan, David; Taylor, Paul; Spicer, James; Lind, Michael; Mitra, Sankhasuvra; Shamash, Jonathan; Phillips, Melissa M.; Luong, Phuong; Payne, Sarah; Hillman, Paul; Ellis, Stephen; Szyszko, Teresa; Dancey, Gairin; Butcher, Lee; Beck, Stephan; Avril, Norbert E.; Thomson, Jim; Johnston, Amanda; Tomsa, Marianne; Lawrence, Cheryl; Schmid, Peter; Crook, Timothy; Wu, Bor-Wen; Bomalaski, John S.; Lemoine, Nicholas; Sheaff, Michael T.; Rudd, Robin M.; Fennell, Dean; Hackshaw, Allan

doi:10.1001/jamaoncol.2016.3049

All Outputs (3)

EGFR and related therapeutic targets in malignant pleural mesothelioma (2016)
Thesis
Oguh, L. I. (2016). EGFR and related therapeutic targets in malignant pleural mesothelioma. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221787

Introduction
Malignant pleural mesothelioma (MPM) is a rare but aggressive disease and the current first line treatment is associated with a survival rate of 40%. There is currently no second line therapy. This study aimed to explore the expression... Read More about EGFR and related therapeutic targets in malignant pleural mesothelioma.

Investigating the role of microRNA-31 as a modulator of chemosensitivity in malignant leural mesothelioma (2016)
Thesis
Moody, H. L. (2016). Investigating the role of microRNA-31 as a modulator of chemosensitivity in malignant leural mesothelioma. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4219227

Malignant pleural mesothelioma (MPM) is associated with an extremely poor prognosis and the majority of patients are initially or rapidly become unresponsive to platinum-based chemotherapy. MicroRNA-31 (miR-31) is encoded on a genomic fragile site, 9... Read More about Investigating the role of microRNA-31 as a modulator of chemosensitivity in malignant leural mesothelioma.

Arginine deprivation with pegylated Arginine Deiminase in patients with Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial (2016)
Journal Article
Szlosarek, P. W., Steele, J. P., Nolan, L., Gilligan, D., Taylor, P., Spicer, J., Lind, M., Mitra, S., Shamash, J., Phillips, M. M., Luong, P., Payne, S., Hillman, P., Ellis, S., Szyszko, T., Dancey, G., Butcher, L., Beck, S., Avril, N. E., Thomson, J., …Hackshaw, A. (2017). Arginine deprivation with pegylated Arginine Deiminase in patients with Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial. JAMA Oncology, 3(1), 58-66. https://doi.org/10.1001/jamaoncol.2016.3049

Importance: Preclinical studies show that arginine deprivation is synthetically lethal in argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothelioma. The role of the arginine-lowering agent pegylated arginine deiminase (ADI-PEG20)... Read More about Arginine deprivation with pegylated Arginine Deiminase in patients with Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial.