Skip to main content

Research Repository

Advanced Search

All Outputs (228)

Deactivation of implantable defibrillators at the end of life - A register-based study of ICD-deactivation at home and the impact of palliative care (2023)
Journal Article
Höijer, C. J., & Johnson, M. J. (2023). Deactivation of implantable defibrillators at the end of life - A register-based study of ICD-deactivation at home and the impact of palliative care. International journal of cardiology, 386, 91-94. https://doi.org/10.1016/j.ijcard.2023.05.046

Background: The Implantable Cardioverter-Defibrillator (ICD) is a well-established life-saving therapy for heart failure patients, but due to the risk for unnecessary shocks, deactivation of ICD:s is recommended at the end of life. We aimed to identi... Read More about Deactivation of implantable defibrillators at the end of life - A register-based study of ICD-deactivation at home and the impact of palliative care.

Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool (2023)
Journal Article
Goedegebuur, J., Abbel, D., Accassat, S., Achterberg, W. P., Akbari, A., Arfuch, V. M., …Noble, S. I. (2023). Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool. Thrombosis Research, 228, 54-60. https://doi.org/10.1016/j.thromres.2023.05.008

BACKGROUND: Even though antithrombotic therapy has probably little or even negative effects on the well-being of people with cancer during their last year of life, deprescribing antithrombotic therapy at the end of life is rare in practice. It is oft... Read More about Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool.

Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial) (2023)
Journal Article
Sousa, M. S., Martin, P., Johnson, M. J., Lind, M., Maddocks, M., Bullock, A., Agar, M., Chang, S., Kochovska, S., Kinchin, I., Morgan, D., Fazekas, B., Razmovski-Naumovski, V., Lee, J. T., Itchins, M., Bray, V., & Currow, D. C. (2023). Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial). PLoS ONE, 18(5 May), Article e0285850. https://doi.org/10.1371/journal.pone.0285850

Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, p... Read More about Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial).

A non-randomised controlled study to assess the effectiveness of a new proactive multidisciplinary care intervention for older people living with frailty (2023)
Journal Article
Murtagh, F. E., Okoeki, M., Ukoha-kalu, B. O., Khamis, A., Clark, J., Boland, J. W., …Johnson, M. J. (2023). A non-randomised controlled study to assess the effectiveness of a new proactive multidisciplinary care intervention for older people living with frailty. BMC Geriatrics, 23(1), Article 6. https://doi.org/10.1186/s12877-023-03727-2

Background Integrated care may improve outcomes for older people living with frailty. We aimed to assess the effectiveness of a new, anticipatory, multidisciplinary care service in improving the wellbeing and quality of life (QoL) of older people li... Read More about A non-randomised controlled study to assess the effectiveness of a new proactive multidisciplinary care intervention for older people living with frailty.

Experiences of a Novel Integrated Service for Older Adults at Risk of Frailty: A Qualitative Study (2023)
Journal Article
Wilson, I., Ukoha-kalu, B. O., Okoeki, M., Clark, J., Boland, J. W., Pask, S., …Murtagh, F. E. (2023). Experiences of a Novel Integrated Service for Older Adults at Risk of Frailty: A Qualitative Study. Journal of Patient Experience, 10, https://doi.org/10.1177/23743735231199827

The UK has a significant and growing population of older adults with frailty and complex healthcare needs, necessitating innovative care solutions. This study aimed to explore patients’ and carers’ experiences of a novel integrated service that was s... Read More about Experiences of a Novel Integrated Service for Older Adults at Risk of Frailty: A Qualitative Study.

Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction (2023)
Journal Article
Bravington, A., Obita, G., Baddeley, E., Johnson, M. J., Murtagh, F. E., Currow, D. C., …Boland, J. W. (2023). Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction. PLoS ONE, 18(8), Article e0289501. https://doi.org/10.1371/journal.pone.0289501

BACKGROUND: Malignant bowel obstruction is experienced by 15% of people with advanced cancer, preventing them from eating and drinking and causing pain, nausea and vomiting. Surgery is not always appropriate. Management options include tube or stent... Read More about Development of a Core Outcome Set for the research and assessment of inoperable malignant bowel obstruction.

‘It’s tough. It is hard’: A qualitative interview study of staff and volunteers caring for hospice in-patients with delirium (2023)
Journal Article
Featherstone, I., Siddiqi, N., Jones, L., Coppo, E., Sheldon, T., Hosie, A., …Johnson, M. J. (2023). ‘It’s tough. It is hard’: A qualitative interview study of staff and volunteers caring for hospice in-patients with delirium. Palliative medicine, https://doi.org/10.1177/02692163231170655

Background: Delirium is a distressing condition often experienced by hospice in-patients. Increased understanding of current multidisciplinary care of delirium is needed to develop interventions in this setting. Aim(s): To explore hospice staff and v... Read More about ‘It’s tough. It is hard’: A qualitative interview study of staff and volunteers caring for hospice in-patients with delirium.

Predictors of hospital admission when presenting with acute-on-chronic breathlessness: binary logistic regression (2023)
Journal Article
Hutchinson, A., Pickering, A., Williams, P., & Johnson, M. (2023). Predictors of hospital admission when presenting with acute-on-chronic breathlessness: binary logistic regression. PLoS ONE, 18(8), Article e0289263. https://doi.org/10.1371/journal.pone.0289263

BACKGROUND: Breathlessness due to medical conditions commonly causes emergency department presentations and unplanned admissions. Acute-on-chronic breathlessness is a reason for 20% of emergency presentations by ambulance with 69% of these being admi... Read More about Predictors of hospital admission when presenting with acute-on-chronic breathlessness: binary logistic regression.

Effect of regular low-dose extended-release morphine on chronic breathlessness in chronic obstructive pulmonary disease: the BEAMS randomized clinical trial (2022)
Journal Article
Ekström, M., Ferreira, D., Chang, S., Louw, S., Johnson, M. J., Eckert, D. J., …Currow, D. C. (2022). Effect of regular low-dose extended-release morphine on chronic breathlessness in chronic obstructive pulmonary disease: the BEAMS randomized clinical trial. Journal of the American Medical Association, 328(20), 2022-2032. https://doi.org/10.1001/jama.2022.20206

Importance: Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing is needed. Objective: To det... Read More about Effect of regular low-dose extended-release morphine on chronic breathlessness in chronic obstructive pulmonary disease: the BEAMS randomized clinical trial.

Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study) (2022)
Journal Article
Benelhaj, N. E., Hutchinson, A., Maraveyas, A., & Johnson, M. (2022). Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study). PLoS ONE, 17(10), Article e0276754. https://doi.org/10.1371/journal.pone.0276754

Background: The diagnosis of symptomatic cancer-associated thrombosis often causes distress and alarm for patients, especially for those unaware of the risk, or the signs and symptoms to look out for. There are few data about cancer patients’ experie... Read More about Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study).

Respiratory distress symptom intervention for non-pharmacological management of the lung cancer breathlessness-cough-fatigue symptom cluster: randomised controlled trial (2022)
Journal Article
Yorke, J., Johnson, M. J., Punnett, G., Smith, J., Blackhall, F., Lloyd Williams, M., …Molassiotis, A. (in press). Respiratory distress symptom intervention for non-pharmacological management of the lung cancer breathlessness-cough-fatigue symptom cluster: randomised controlled trial. BMJ supportive & palliative care, https://doi.org/10.1136/spcare-2022-003924

Objectives: In lung cancer, three prominent symptoms, such as breathlessness, cough and fatigue, are closely related with each other forming a 'respiratory distress symptom cluster'. The aim of this study was to determine the clinical and cost-effect... Read More about Respiratory distress symptom intervention for non-pharmacological management of the lung cancer breathlessness-cough-fatigue symptom cluster: randomised controlled trial.

Invisibility of breathlessness in clinical consultations: a cross-sectional, national online survey (2022)
Journal Article
Kochovska, S., Chang, S., Ferreira, D., Brunelli, V. N., Luckett, T., Morgan, L., …Currow, D. C. (2022). Invisibility of breathlessness in clinical consultations: a cross-sectional, national online survey. European respiratory journal, 60(5), Article 2201603. https://doi.org/10.1183/13993003.01603-2022

Breathlessness diminishes the physical, mental and social wellbeing of people living long-term with this disabling symptom [1]. Identifying its impacts on patients and their families helps to inform appropriate non-pharmacological and pharmacological... Read More about Invisibility of breathlessness in clinical consultations: a cross-sectional, national online survey.

The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: A systematic review (2022)
Journal Article
Seddon, K., Bravington, A., Obita, G., Baddeley, E., Johnson, M. J., Murtagh, F. E., Currow, D. C., Boland, E. G., Nelson, A., Oliver, A., Noble, S. I., & Boland, J. W. (2022). The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: A systematic review. Palliative medicine, 36(9), 1336-1350. https://doi.org/10.1177/02692163221122352

Background: Malignant bowel obstruction, a complication of certain advanced cancers, causes severe symptoms which profoundly affect quality of life. Clinical management remains complex, and outcome assessment is inconsistent. Aim: To identify outc... Read More about The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: A systematic review.

The assessment and management of unintentional weight loss associated with cachexia in a primary care setting: a mixed-methods study (2022)
Thesis
Nwulu, U. U. (2022). The assessment and management of unintentional weight loss associated with cachexia in a primary care setting: a mixed-methods study. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4420753

Introduction: Unintentional weight loss (UWL) is the main symptom of cachexia, a multifactorial syndrome associated with advanced disease. Other symptoms include loss of appetite and muscle weakness. UWL in older adults can be caused by many disease... Read More about The assessment and management of unintentional weight loss associated with cachexia in a primary care setting: a mixed-methods study.

Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings (2022)
Journal Article
Hutchinson, A., Allgar, V., Cohen, J., Currow, D. C., Griffin, S., Hart, S., …Johnson, M. J. (2022). Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings. ERJ Open Research, 8(4), Article 00257-2022. https://doi.org/10.1183/23120541.00257-2022

Introduction: One-fifth of emergency department presentations by ambulance are due to acute-on-chronic breathlessness. We explored the feasibility of an evaluation-phase, cluster randomised controlled trial (cRCT) of the effectiveness and cost-effect... Read More about Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings.

Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review (2022)
Journal Article
Patterson, M., Greenley, S., Ma, Y., Bullock, A., Curry, J., Smithson, J., …Johnson, M. J. (2022). Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review. BMJ supportive & palliative care, Article 003492. https://doi.org/10.1136/bmjspcare-2021-003492

Background: Parenteral nutrition (PN) and palliative venting gastrostomies (PVG) are two interventions used clinically to manage inoperable malignant bowel obstruction (MBO); however, little is known about their role in clinical and quality-of-life o... Read More about Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2022)
Journal Article
Pearson, M., Jackson, G., Jackson, C., Boland, J., Featherstone, I., Huang, C., …Johnson, M. (2022). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. BMJ open, 12(7), Article e060450. https://doi.org/10.1136/bmjopen-2021-060450

INTRODUCTION: Delirium is a complex condition in which altered mental state and cognition causes severe distress and poor clinical outcomes for patients and families, anxiety and stress for the health professionals and support staff providing care, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

Comparing recalled versus experienced symptoms of breathlessness ratings: An ecological assessment study using mobile phone technology (2022)
Journal Article
Sandberg, J., Sundh, J., Anderberg, P., Currow, D. C., Johnson, M., Lansing, R., & Ekström, M. (2022). Comparing recalled versus experienced symptoms of breathlessness ratings: An ecological assessment study using mobile phone technology. Respirology : official journal of the Asian Pacific Society of Respirology, https://doi.org/10.1111/resp.14313

Background and objective: Recall of breathlessness is important for clinical care but might differ from the experienced (momentary) symptoms. This study aimed to characterize the relationship between momentary breathlessness ratings and the recall of... Read More about Comparing recalled versus experienced symptoms of breathlessness ratings: An ecological assessment study using mobile phone technology.

CPR Heart Failure Interview study (2022)
Data
CPR Heart Failure Interview study. [Data]

Academic F2 doctor interview study of CPR conversations for people with heart failure