All Outputs (3)

Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice (2022)
Journal Article
Ben-Yehuda Greenwald, M., Liu, Y. H., Li, W., Hiebert, P., Zubair, M., Tenor, H., …Werner, S. (2022). Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice. Pharmaceutics, 14(11), Article 2358. https://doi.org/10.3390/pharmaceutics14112358

Chronic, non-healing wounds constitute a major health problem, and the current therapeutic options are limited. Therefore, pharmaceuticals that can be locally applied to complicated wounds are urgently needed. Such treatments should directly target t... Read More about Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice.

Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis (2022)
Journal Article
Hiebert, P., Martyts, A., Schwestermann, J., Janke, K., Hafner, J., Boukamp, P., …Werner, S. (2022). Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis. Matrix Biology, 113, 39-60. https://doi.org/10.1016/j.matbio.2022.09.002

Aging is associated with progressive skin fragility and a tendency to tear, which can lead to severe clinical complications. The transcription factor NRF2 is a key regulator of the cellular antioxidant response, and pharmacological NRF2 activation is... Read More about Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis.

Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis (2022)
Journal Article
Koch, M., Kockmann, T., Rodriguez, E., Wehkamp, U., Hiebert, P., Ben-Yehuda Greenwald, M., …auf dem Keller, U. (2023). Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis. Journal of Investigative Dermatology, 143(2), 220-231.e7. https://doi.org/10.1016/j.jid.2022.08.048

Atopic dermatitis is the most common inflammatory skin disease and is characterized by a deficient epidermal barrier and cutaneous inflammation. Genetic studies suggest a key role of keratinocytes in atopic dermatitis pathogenesis, but the alteration... Read More about Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis.