All Outputs (11)

A Lysyl Oxidase-Responsive Collagen Peptide Illuminates Collagen Remodeling in Wound Healing (2024)
Journal Article
Hiebert, P., Antoniazzi, G., Aronoff, M., Werner, S., & Wennemers, H. (2024). A Lysyl Oxidase-Responsive Collagen Peptide Illuminates Collagen Remodeling in Wound Healing. Matrix Biology, 128, 11-20. https://doi.org/10.1016/j.matbio.2024.02.006

Tissue repair and fibrosis involve the dynamic remodeling of collagen, and accurate detection of these sites is of utmost importance. Here, we use a collagen peptide sensor (1) to visualize collagen formation and remodeling during wound healing in mi... Read More about A Lysyl Oxidase-Responsive Collagen Peptide Illuminates Collagen Remodeling in Wound Healing.

Release of miR-29 Target Laminin C2 Improves Skin Repair (2023)
Journal Article
Robinson, C. J., Thiagarajan, L., Maynard, R., Aruketty, M., Herrera, J., Dingle, L., …Kurinna, S. (2024). Release of miR-29 Target Laminin C2 Improves Skin Repair. American Journal of Pathology, 194(2), 195-208. https://doi.org/10.1016/j.ajpath.2023.11.002

miRNAs are small noncoding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in murine and human skin, where it may regulate functions in skin repair. Cutaneous wound healing model in miR-29a/b1 gene knockout mice was use... Read More about Release of miR-29 Target Laminin C2 Improves Skin Repair.

Targeting NRF2 to promote epithelial repair (2023)
Journal Article
Hiebert, P., & Werner, S. (2023). Targeting NRF2 to promote epithelial repair. Biochemical Society Transactions, 51(1), 101-111. https://doi.org/10.1042/BST20220228

The transcription factor NRF2 is well known as a master regulator of the cellular stress response. As such, activation of NRF2 has gained widespread attention for its potential to prevent tissue injury, but also as a possible therapeutic approach to... Read More about Targeting NRF2 to promote epithelial repair.

Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice (2022)
Journal Article
Ben-Yehuda Greenwald, M., Liu, Y. H., Li, W., Hiebert, P., Zubair, M., Tenor, H., …Werner, S. (2022). Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice. Pharmaceutics, 14(11), Article 2358. https://doi.org/10.3390/pharmaceutics14112358

Chronic, non-healing wounds constitute a major health problem, and the current therapeutic options are limited. Therefore, pharmaceuticals that can be locally applied to complicated wounds are urgently needed. Such treatments should directly target t... Read More about Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice.

Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis (2022)
Journal Article
Hiebert, P., Martyts, A., Schwestermann, J., Janke, K., Hafner, J., Boukamp, P., …Werner, S. (2022). Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis. Matrix Biology, 113, 39-60. https://doi.org/10.1016/j.matbio.2022.09.002

Aging is associated with progressive skin fragility and a tendency to tear, which can lead to severe clinical complications. The transcription factor NRF2 is a key regulator of the cellular antioxidant response, and pharmacological NRF2 activation is... Read More about Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis.

Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis (2022)
Journal Article
Koch, M., Kockmann, T., Rodriguez, E., Wehkamp, U., Hiebert, P., Ben-Yehuda Greenwald, M., …auf dem Keller, U. (2023). Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis. Journal of Investigative Dermatology, 143(2), 220-231.e7. https://doi.org/10.1016/j.jid.2022.08.048

Atopic dermatitis is the most common inflammatory skin disease and is characterized by a deficient epidermal barrier and cutaneous inflammation. Genetic studies suggest a key role of keratinocytes in atopic dermatitis pathogenesis, but the alteration... Read More about Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis.

Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide (2021)
Journal Article
Aronoff, M. R., Hiebert, P., Hentzen, N. B., Werner, S., & Wennemers, H. (2021). Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide. Nature Chemical Biology, 17(8), 865-871. https://doi.org/10.1038/s41589-021-00830-6

Collagens are fibrous proteins that are integral to the strength and stability of connective tissues. During collagen maturation, lysyl oxidases (LOX) initiate the cross-linking of fibers, but abnormal LOX activity is associated with impaired tissue... Read More about Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide.

The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix (2021)
Journal Article
Hiebert, P. (2021). The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix. Matrix Biology Plus, 10, Article 100057. https://doi.org/10.1016/j.mbplus.2021.100057

The transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) is widely recognized as a master regulator of the cellular stress response by facilitating the transcription of cytoprotective genes. As such, the Nrf2 pathway is critical in... Read More about The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix.

A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes (2020)
Journal Article
Ben-Yehuda Greenwald, M., Tacconi, C., Jukic, M., Joshi, N., Hiebert, P., Brinckmann, J., …Werner, S. (2021). A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes. Journal of Investigative Dermatology, 141(2), 415-426. https://doi.org/10.1016/j.jid.2020.05.111

Chronic wounds affect a large percentage of the population worldwide and cause significant morbidity. Unfortunately, efficient compounds for the treatment of chronic wounds are yet not available. Endothelial dysfunction, which is at least in part a r... Read More about A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes.

Comprehensive characterization of myeloid cells during wound healing in healthy and healing-impaired diabetic mice (2020)
Journal Article
Joshi, N., Pohlmeier, L., Ben-Yehuda Greenwald, M., Haertel, E., Hiebert, P., Kopf, M., & Werner, S. (2020). Comprehensive characterization of myeloid cells during wound healing in healthy and healing-impaired diabetic mice. European journal of immunology, 50(9), 1335-1349. https://doi.org/10.1002/eji.201948438

Wound healing involves the concerted action of various lymphoid and in particular myeloid cell populations. To characterize and quantitate different types of myeloid cells and to obtain information on their kinetics during wound healing, we performed... Read More about Comprehensive characterization of myeloid cells during wound healing in healthy and healing-impaired diabetic mice.

Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-Like Lesions in Mice via NRF2 Activation (2019)
Journal Article
Lee, J., Song, K., Hiebert, P., Werner, S., Kim, T. G., & Kim, Y. S. (2020). Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-Like Lesions in Mice via NRF2 Activation. Journal of Investigative Dermatology, 140(6), 1223-1232.e4. https://doi.org/10.1016/j.jid.2019.12.008

Psoriasis is a common inflammatory skin disorder that is characterized by keratinocyte hyperproliferation and abnormal differentiation, resulting in the thickening of the epidermis and stratum corneum. In this study, we investigated in vitro and in v... Read More about Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-Like Lesions in Mice via NRF2 Activation.