All Outputs (4)

Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours (2012)
Thesis
Smith, R. (2012). Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219918

To establish accurate and early stage tumour diagnosis, quantitative molecular imaging modalities such as positron emission tomography (PET) are being employed. Molecular probes containing a positron emitting isotope (e.g. ¹⁸F, ⁶⁴Cu) are designed to... Read More about Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours.

Polyacrylamide nanoparticle delivery systems in photodynamic therapy (2011)
Thesis
Kuruppuarachchi, M. (2011). Polyacrylamide nanoparticle delivery systems in photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4213126

In treating many diseases, including cancer and bacterial infections, drug resistance has emerged as a major obstacle limiting the therapeutic efficacy of chemotherapeutic agents. One area which may prove to be particularly attractive is Photodynamic... Read More about Polyacrylamide nanoparticle delivery systems in photodynamic therapy.

Synthesis of tetraazamacrocyclic complexes: Biomedical applications (2009)
Thesis
Mewis, R. E. (2009). Synthesis of tetraazamacrocyclic complexes: Biomedical applications. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208988

Tetraazamacrocyclic frameworks of 1,4,7,10-tetraazacylcododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) with functional pendent arms and porphyrins with solubilising polyethylene glycol (PEG) chains have been synthesised. The pendent... Read More about Synthesis of tetraazamacrocyclic complexes: Biomedical applications.

Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer (2008)
Thesis
Welch, C. J. (2008). Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208906

Porphyrin molecules are efficient generators of singlet oxygen and are used as photosensitisers in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting... Read More about Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer.