Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
(2011)
Journal Article
Carnell, M., Zech, T., Calaminus, S. D., Ura, S., Hagedorn, M., Johnston, S. A., May, R. C., Soldati, T., Machesky, L. M., & Insall, R. H. (2011). Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. Journal of Cell Biology, 193(5), 831-839. https://doi.org/10.1083/jcb.201009119
WASP and SCAR homologue (WASH) is a recently identified and evolutionarily conserved regulator of actin polymerization. In this paper, we show that WASH coats mature Dictyostelium discoideum lysosomes and is essential for exocytosis of indigestible m... Read More about Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis.