All Outputs (3)

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 (2016)
Journal Article
Watson, C. N., Cox, D., Watson, S. P., Arman, M., Henderson, I. R., & Kerrigan, S. W. (2016). Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets, 27(6), 535-540. https://doi.org/10.3109/09537104.2016.1148129

Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human p... Read More about Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3.

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane (2013)
Journal Article
Schachtner, H., Calaminus, S. D. J., Sinclair, A., Monypenny, J., Blundell, M. P., Leon, C., Holyoake, T. L., Thrasher, A. J., Michie, A. M., Vukovic, M., Gachet, C., Jones, G. E., Thomas, S. G., Watson, S. P., & Machesky, L. M. (2013). Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood, 121(13), 2542-2552. https://doi.org/10.1182/blood-2012-07-443457

Megakaryocytes give rise to platelets via extension of proplatelet arms, which are released through the vascular sinusoids into the bloodstream. Megakaryocytes and their precursors undergo varying interactions with the extracellular environment in th... Read More about Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.

Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading (2008)
Journal Article
Calaminus, S. D. J., Thomas, S., McCarty, O. J. T., Machesky, L. M., & Watson, S. P. (2008). Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. Journal of thrombosis and haemostasis : JTH, 6(11), 1944-1952. https://doi.org/10.1111/j.1538-7836.2008.03141.x

During platelet spreading, the actin cytoskeleton undergoes marked changes, forming filopodia, lamellipodia and stress fibres. In the present study, we report the identification of a novel actin-rich structure, termed an actin nodule, which appears p... Read More about Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading.