All Outputs (8)

Endothelial cells and cancer (2006)
Book Chapter
Nikitenko, L., & Boshoff, C. (2006). Endothelial cells and cancer. In S. Moncada, & A. Higgs (Eds.), The Vascular Endothelium II (307-334). Springer Verlag. https://doi.org/10.1007/3-540-36028-X_10

Endothelial cells play a key role in the development and function of blood and lymph vessels. Excessive proliferation and transformation of endothelial cells lead to pathological angiogenesis/ lymphangiogenesis or vascular malfunctions which are hall... Read More about Endothelial cells and cancer.

Differential functions of tissue factor in the trans-activation of cellular signalling pathways (2006)
Journal Article
Ettelaie, C., Li, C., Collier, M. E. W., Pradier, A., Frentzou, G. A., Wood, C. G., Chetter, I. C., McCollum, P. T., Bruckdorfer, K. R., & James, N. J. (2007). Differential functions of tissue factor in the trans-activation of cellular signalling pathways. Atherosclerosis, 194(1), 88-101. https://doi.org/10.1016/j.atherosclerosis.2006.10.010

In this study we examined the ability of tissue factor (TF) alone, or in conjunction with factor VIIa, factor Xa and TFPI in activating a number of key signalling pathways associated with cellular growth, stress and differentiation responses in human... Read More about Differential functions of tissue factor in the trans-activation of cellular signalling pathways.

Development of a GC-MS Method for the Simultaneous Analysis of Latent Fingerprint Components (2006)
Journal Article
Croxton, R. S., Baron, M. G., Butler, D., Kent, T., & Sears, V. G. (2006). Development of a GC-MS Method for the Simultaneous Analysis of Latent Fingerprint Components. Journal of Forensic Sciences, 51(6), 1329-1333. https://doi.org/10.1111/j.1556-4029.2006.00203.x

Latent fingerprint residue is a complex mixture of organic and inorganic compounds. A full understanding of the composition of this mixture and how it changes after deposition is lacking. Three solvent systems were compared for the simultaneous extrac... Read More about Development of a GC-MS Method for the Simultaneous Analysis of Latent Fingerprint Components.

Endo180 (2006)
Digital Artefact
Wienke, D., Sturge, J., Pirinen, N. J., Henry, L. A., Davies, G. C., & Isacke, C. M. Endo180

Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo 180 to promote adhesion disassembly (2006)
Journal Article
Sturge, J., Wienke, D., & Isacke, C. M. (2006). Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo 180 to promote adhesion disassembly. Journal of Cell Biology, 175(2), 337-347. https://doi.org/10.1083/jcb.200602125

The regulated assembly and disassembly of focal adhesions and adherens junctions contributes to cell motility and tumor invasion. Pivotal in this process is phosphorylation of myosin light chain-2 (MLC2) by Rho kinase (ROCK) downstream of Rho activat... Read More about Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo 180 to promote adhesion disassembly.

Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density (2006)
Journal Article
Nikitenko, L. L., Cross, T., Campo, L., Turley, H., Leek, R., Manek, S., Bicknell, R., & Rees, M. C. (2006). Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density. Clinical cancer research : an official journal of the American Association for Cancer Research, 12(19), 5648-5658. https://doi.org/10.1158/1078-0432.CCR-06-0852

Purpose: The role for the hypoxia-inducible angiogenic factor adrenomedullin (AM) in tumor growth and progression has been suggested. Calcitonin receptor - like receptor (CL) is a G protein - coupled receptor (GPCR) that mediates effects of AM, but l... Read More about Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density.

Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism (2006)
Journal Article
Nikitenko, L. L., Blucher, N., Fox, S. B., Bicknell, R., Smith, D. M., & Rees, M. C. (2006). Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism. Journal of cell science, 119(5), 910-922. https://doi.org/10.1242/jcs.02783

Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are related peptides with distinct pharmacological profiles. Calcitonin-receptor-like receptor (CRLR, now known as CL) can function as either an AM receptor or a CGRP receptor, when cotra... Read More about Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism.

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis (2006)
Journal Article
Jossé, L., Harley, M. E., Monteiro dos Santos Pires, I., & Hughes, D. A. (2006). Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Biochemical Journal, 393(1), 303-309. https://doi.org/10.1042/BJ20051238

Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast and fission yeast tha... Read More about Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.