DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation
(2014)
Journal Article
Pellacani, D., Kestoras, D., Droop, A. P., Frame, F. M., Berry, P. A., Lawrence, M. G., Stower, M. J., Simms, M. S., Mann, V. M., Collins, A. T., Risbridger, G. P., & Maitland, N. J. (2014). DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation. Cell Death and Differentiation, 21(5), 761-773. https://doi.org/10.1038/cdd.2013.202
Prostate cancer (CaP) is mostly composed of luminal-like differentiated cells, but contains a small subpopulation of basal cells (including stem-like cells), which can proliferate and differentiate into luminal-like cells. In cancers, CpG island hype... Read More about DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.