All Outputs (953)

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers (2013)
Journal Article
Simpson, K. L., Cawthorne, C., Zhou, C., Hodgkinson, C. L., Walker, M. J., Trapani, F., Kadirvel, M., Brown, G., Dawson, M. J., MacFarlane, M., Williams, K. J., Whetton, A. D., & Dive, C. (2013). A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death and Disease, 4(5), e613-e613. https://doi.org/10.1038/cddis.2013.137

Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal t... Read More about A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.

Secondary bone tumors in prostate cancer: New treatments on the horizon (2013)
Book Chapter
Sturge, J. (2013). Secondary bone tumors in prostate cancer: New treatments on the horizon. In M. Berhouma (Ed.), Bone tumors: Symptoms, diagnosis and treatment (145-175). Nova Science Publishers

Secondary bone tumors associated with the advancement of solid tumors of the prostate and other tissue sites result in the increased risk of intractable bone pain, pathological skeletal fracture and spinal-cord compression. In addition to increasing... Read More about Secondary bone tumors in prostate cancer: New treatments on the horizon.

CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A (2013)
Journal Article
Cazares-Körner, C., Pires, I. M., Swallow, I. D., Grayer, S. C., O'Connor, L. J., Olcina, M. M., Christlieb, M., Conway, S. J., & Hammond, E. M. (2013). CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A. ACS Chemical Biology, 8(7), 1451-1459. https://doi.org/10.1021/cb4001537

The increased resistance of hypoxic cells to all forms of cancer therapy presents a major barrier to the successful treatment of most solid tumors. Inhibition of the essential kinase Checkpoint kinase 1 (Chk1) has been described as a promising cancer... Read More about CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A.

High and low, but not intermediate, PRAME expression levels are poor prognostic markers in myelodysplastic syndrome at disease presentation (2013)
Journal Article
Liberante, F. G., Pellagatti, A., Boncheva, V., Bowen, D. T., Mills, K. I., Boultwood, J., & Guinn, B. A. (2013). High and low, but not intermediate, PRAME expression levels are poor prognostic markers in myelodysplastic syndrome at disease presentation. British journal of haematology, 162(2), 282-285. https://doi.org/10.1111/bjh.12352

A Missense Mutation in the Sodium Channel β2 Subunit Reveals SCN2B as a New Candidate Gene for Brugada Syndrome (2013)
Journal Article
Riuró, H., Beltran-Alvarez, P., Tarradas, A., Selga, E., Campuzano, O., Vergés, M., Pagans, S., Iglesias, A., Brugada, J., Brugada, P., Vázquez, F. M., Pérez, G. J., Scornik, F. S., & Brugada, R. (2013). A Missense Mutation in the Sodium Channel β2 Subunit Reveals SCN2B as a New Candidate Gene for Brugada Syndrome. Human Mutation, 34(7), 961-966. https://doi.org/10.1002/humu.22328

Brugada Syndrome (BrS) is a familial disease associated with sudden cardiac death. A 20%-25% of BrS patients carry genetic defects that cause loss-of-function of the voltage-gated cardiac sodium channel. Thus, 70%-75% of patients remain without a gen... Read More about A Missense Mutation in the Sodium Channel β2 Subunit Reveals SCN2B as a New Candidate Gene for Brugada Syndrome.

Photothermal colloid antibodies for shape-selective recognition and killing of microorganisms (2013)
Journal Article
Borovička, J., Metheringham, W. J., Madden, L. A., Walton, C. D., Stoyanov, S. D., & Paunov, V. N. (2013). Photothermal colloid antibodies for shape-selective recognition and killing of microorganisms. Journal of the American Chemical Society, 135(14), 5282-5285. https://doi.org/10.1021/ja400781f

We have developed a class of selective antimicrobial agents based on the recognition of the shape and size of the bacterial cells. These agents are anisotropic colloid particles fabricated as negative replicas of the target cells which involve templa... Read More about Photothermal colloid antibodies for shape-selective recognition and killing of microorganisms.

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane (2013)
Journal Article
Schachtner, H., Calaminus, S. D. J., Sinclair, A., Monypenny, J., Blundell, M. P., Leon, C., Holyoake, T. L., Thrasher, A. J., Michie, A. M., Vukovic, M., Gachet, C., Jones, G. E., Thomas, S. G., Watson, S. P., & Machesky, L. M. (2013). Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood, 121(13), 2542-2552. https://doi.org/10.1182/blood-2012-07-443457

Megakaryocytes give rise to platelets via extension of proplatelet arms, which are released through the vascular sinusoids into the bloodstream. Megakaryocytes and their precursors undergo varying interactions with the extracellular environment in th... Read More about Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.

Parallels between embryo and cancer cell metabolism (2013)
Journal Article
Smith, D., & Sturmey, R. (2013). Parallels between embryo and cancer cell metabolism. Biochemical Society Transactions, 41(2), 664 - 669. https://doi.org/10.1042/BST20120352

A key characteristic of cancer cells is the ability to switch from a predominantly oxidative metabolism to glycolysis and the production of lactate even when oxygen is plentiful. This metabolic switch, known as the Warburg effect, was first described... Read More about Parallels between embryo and cancer cell metabolism.

The automated monocyte count is independently predictive of overall survival from diagnosis in chronic lymphocytic leukaemia and of survival following first-line chemotherapy (2013)
Journal Article
Mazumdar, R., Evans, P., Culpin, R., Bailey, J., & Allsup, D. (2013). The automated monocyte count is independently predictive of overall survival from diagnosis in chronic lymphocytic leukaemia and of survival following first-line chemotherapy. Leukemia Research, 37(6), 614-618. https://doi.org/10.1016/j.leukres.2013.02.020

We conducted an analysis of the effect of monocytosis at diagnosis of CLL on subsequent overall (OS) and treatment-free survival (TFS). Monocyte counts were performed using the Sysmex XE2100™ analyser. A monocyte count >0.91×109L-1 at the time of dia... Read More about The automated monocyte count is independently predictive of overall survival from diagnosis in chronic lymphocytic leukaemia and of survival following first-line chemotherapy.

p38 alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles (2013)
Journal Article
Ettelaie, C., ElKeeb, A. M., Maraveyas, A., & Collier, M. E. W. (2013). p38 alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles. BBA - Molecular Cell Research, 1833(3), 613-621. https://doi.org/10.1016/j.bbamcr.2012.11.010

We previously showed that the phosphorylation of Ser253 within the cytoplasmic domain of human tissue factor (TF) initiates the incorporation and release of this protein into cell-derived microparticles. Furthermore, subsequent phosphorylation of Ser... Read More about p38 alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles.

New targets for the immunotherapy of colon cancer - Does reactive disease hold the answer (2013)
Journal Article
Boncheva, V., Bonney, S. A., Brooks, S. E., Tangney, M., O'Sullivan, G., Mirnezami, A., & Guinn, B. A. (2013). New targets for the immunotherapy of colon cancer - Does reactive disease hold the answer. Cancer Gene Therapy, 20(3), 157-168. https://doi.org/10.1038/cgt.2013.5

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both men and women, posing a serious demographic and economic burden worldwide. In the United Kingdom, CRC affects 1 in every 20 people and it is often detected once well establ... Read More about New targets for the immunotherapy of colon cancer - Does reactive disease hold the answer.

[18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941 (2013)
Journal Article
Cawthorne, C., Burrows, N., Gieling, R. G., Morrow, C. J., Forster, D., Gregory, J., Radigois, M., Smigova, A., Babur, M., Simpson, K., Hodgkinson, C., Brown, G., McMahon, A., Dive, C., Hiscock, D., Wilson, I., & Williams, K. J. (2013). [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941. Molecular Cancer Therapeutics, 12(5), 819-828. https://doi.org/10.1158/1535-7163.mct-12-0905

The phosphoinositide 3-kinase (PI3K) pathway is deregulated in a range of cancers, and several targeted inhibitors are entering the clinic. This study aimed to investigate whether the positron emission tomography tracer 3′-deoxy-3′-[ 18 F]fluorothymi... Read More about [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941.

Glycoprotein Ibα and FcγRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis (2013)
Journal Article
Tilley, D. O., Arman, M., Smolenski, A., Cox, D., O'Donnell, J. S., Douglas, C. W., Watson, S. P., & Kerrigan, S. W. (2013). Glycoprotein Ibα and FcγRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis. Journal of thrombosis and haemostasis : JTH, 11(5), 941-950. https://doi.org/10.1111/jth.12175

Background: Infective endocarditis (IE) is characterized by thrombus formation on a cardiac valve. The oral bacterium, Streptococcus oralis, is recognized for its ability to colonize damaged heart valves and is frequently isolated from patients with... Read More about Glycoprotein Ibα and FcγRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis.

A Method for Positive and Negative Selection of Plasmodium falciparum Platelet-Mediated Clumping Parasites and Investigation of the Role of CD36 (2013)
Journal Article
Arman, M., Adams, Y., Lindergard, G., & Rowe, J. A. (2013). A Method for Positive and Negative Selection of Plasmodium falciparum Platelet-Mediated Clumping Parasites and Investigation of the Role of CD36. PLoS ONE, 8(2), Article e55453. https://doi.org/10.1371/journal.pone.0055453

Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes (IEs) is a frequently observed parasite adhesion phenotype. The importance of clumping in severe malaria and the molecular mechanisms behind this phenomenon are incompletely un... Read More about A Method for Positive and Negative Selection of Plasmodium falciparum Platelet-Mediated Clumping Parasites and Investigation of the Role of CD36.

Innovative evolution of cancer gene and cellular therapies (2013)
Journal Article
Lam, P., Khan, G., Stripecke, R., Hui, K. M., Kasahara, N., Peng, K. W., & Guinn, B. A. (2013). Innovative evolution of cancer gene and cellular therapies. Cancer Gene Therapy, 20(3), 141-149. https://doi.org/10.1038/cgt.2012.93

We provide an overview of the latest developments in cancer gene therapy - from the bench to early-stage clinical trials. We describe the most recent work of worldwide teams including experienced scientists and clinicians, reflecting the recent emerg... Read More about Innovative evolution of cancer gene and cellular therapies.

GxcC connects Rap and Rac signaling during Dictyostelium development (2013)
Journal Article
Plak, K., Veltman, D., Fusetti, F., Beeksma, J., Rivero, F., Van Haastert, P. J., & Kortholt, A. (2013). GxcC connects Rap and Rac signaling during Dictyostelium development. BMC cell biology, 14(1), Article 6. https://doi.org/10.1186/1471-2121-14-6

Background: Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early development and chemotaxis competent cells RapA induces pseudopod formation by acti... Read More about GxcC connects Rap and Rac signaling during Dictyostelium development.

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema (2013)
Journal Article
Nikitenko, L. L., Shimosawa, T., Henderson, S., Mäkinen, T., Shimosawa, H., Qureshi, U., Pedley, R. B., Rees, M. C., Fujita, T., & Boshoff, C. (2013). Adrenomedullin haploinsufficiency predisposes to secondary lymphedema. Journal of Investigative Dermatology, 133(7), 1768-1776. https://doi.org/10.1038/jid.2013.47

Secondary lymphedema is a debilitating condition, and genetic factors predisposing to its development remain largely unknown. Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the Adm gene (adrenome... Read More about Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei [version 1; peer review: 2 approved] (2013)
Journal Article
Colasante, C., Voncken, F., Manful, T., Ruppert, T., Tielens, A. G. M., van Hellemond, J. J., & Clayton, C. (2013). Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei [version 1; peer review: 2 approved]. F1000Research, 2, Article 27. https://doi.org/10.3410/f1000research.2-27.v1

In kinetoplastid protists, several metabolic pathways, including glycolysis and purine salvage, are located in glycosomes, which are microbodies that are evolutionarily related to peroxisomes. With the exception of some potential transporters for fat... Read More about Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei [version 1; peer review: 2 approved].

Corrigendum (2013)
Journal Article
Waxman, J., Cobb, J. P., Palmieri, C., Rhim, J. S., Pchejetski, D., Mauri, F., Sandison, A., Fonseca, A. V., Rodriguez-Teja, M., Adamarek, A., Gronau, J. H., Kogianni, G., Caley, M. P., & Sturge, J. (2013). Corrigendum. Journal of Pathology, 229(3), e4-e4. https://doi.org/10.1002/path.4156

Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697 (2013)
Journal Article
Agarwal, V., Hodgkinson, V. C., Eagle, G. L., Scaife, L., Lind, M. J., & Cawkwell, L. (2013). Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. International Journal of Oncology, 42(3), 1088-1092. https://doi.org/10.3892/ijo.2013.1784

We have previously shown that specific COX-2 inhibitors, including DuP 697, have anti-proliferative effects on mesothelioma cells and potentiate the cytotoxicity of pemetrexed. Here, we used a novel proteomic approach to explore the mechanism of acti... Read More about Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.