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Over-the-counter cough medicines: New approaches (2015)
Journal Article
Morice, A. H. (2015). Over-the-counter cough medicines: New approaches. Pulmonary Pharmacology and Therapeutics, 35, 149-151. https://doi.org/10.1016/j.pupt.2015.07.006

© 2015 Elsevier Ltd. The global market for over-the-counter (OTC) medicines in the category cough/cold is enormous amounting to 5.77 billion euro in 2014 (source IMS). Despite this enormous healthcare investment, mainly by direct consumer purchase, e... Read More about Over-the-counter cough medicines: New approaches.

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial (2015)
Journal Article
Valle, J. W., Wasan, H., Lopes, A., Backen, A. C., Palmer, D. H., Morris, K., …Bridgewater, J. A. (2015). Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial. The lancet oncology, 16(8), 967-978. https://doi.org/10.1016/S1470-2045%2815%2900139-4

© 2015 Valle et al. Open Access article distributed under the terms of CC BY. Background: Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer; expression of VEGF and its receptors... Read More about Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial.

A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis (2015)
Journal Article
Smith, G. E., Souroullos, P., Cayton, T., Harwood, A., Carradice, D., & Chetter, I. C. (2016). A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis. The journal of vascular access, 17(1), 1-5. https://doi.org/10.5301/jva.5000484

Purpose: Surgical arteriovenous fistula (AVF) or graft (AVG) is preferred to a central venous catheter for dialysis access. Surgical access may suffer thrombosis early after placement and systemic anticoagulation during surgical access formation may... Read More about A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis.

Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm (2015)
Journal Article
Chetter, I., Sweeting, M., Balm, R., Desgranges, P., Ulug, P., Powell, J., & Ruptured Aneurysm Trialists. (2015). Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm. British journal of surgery, 102(10), 1229-1239. https://doi.org/10.1002/bjs.9852

BackgroundThe benefits of endovascular repair of ruptured abdominal aortic aneurysm remain controversial, without any strong evidence about advantages in specific subgroups.MethodsAn individual-patient data meta-analysis of three recent randomized tr... Read More about Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm.

Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: A feasibility pilot (2015)
Journal Article
Johnson, M. J., Simpson, M. I., Currow, D. C., Millman, R. E., Hart, S. P., & Green, G. (2015). Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: A feasibility pilot. BMJ open, 5(6), Article ARTN e007535. https://doi.org/10.1136/bmjopen-2014-007535

Objectives: Neuroimaging in chronic breathlessness is challenging. The study objective was to test the feasibility of magnetoencephalography (MEG) for functional neuroimaging of people with chronic breathlessness. Design: Feasibility pilot study. Set... Read More about Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: A feasibility pilot.

Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial (2015)
Journal Article
Devereux, G., Cotton, S., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A. J., McCormack, K., McPherson, G., Morice, A., Norrie, J., Sullivan, A., Wilson, A., & Price, D. (2015). Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial. Trials, 16(1), Article 267. https://doi.org/10.1186/s13063-015-0782-2

© Devereux et al. Background: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD. Pre... Read More about Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial.

Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: One-year outcomes from the IMPROVE randomized trial (2015)
Journal Article
Braithwaite, B., Greenhalgh, R. M., Grieve, R., Hassan, T. B., Moore, F., Nicholson, A. A., Soong, C. V., Heatley, F., Anjum, A., Kalinowska, G., Gomes, M., Powell, J. T., Hinchliffe, R., Sweeting, M., Thompson, M. M., Thompson, S. G., Ulug, P., Roberts, I., Bell, P. R., Cheetham, A., …Wilson, L. (2015). Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: One-year outcomes from the IMPROVE randomized trial. European Heart Journal, 36(31), 2061-2069. https://doi.org/10.1093/eurheartj/ehv125

© 2015 The Author. Aims To report the longer term outcomes following either a strategy of endovascular repair first or open repair of ruptured abdominal aortic aneurysm, which are necessary for both patient and clinical decision-making. Methods and r... Read More about Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: One-year outcomes from the IMPROVE randomized trial.

Systematic review of compression following treatment for varicose veins (2015)
Journal Article
El-Sheikha, J., Carradice, D., Nandhra, S., Leung, C., Smith, G., Campbell, B., & Chetter, I. (2015). Systematic review of compression following treatment for varicose veins. British journal of surgery, 102(7), 719-725. https://doi.org/10.1002/bjs.9788

Background Consensus regarding compression following treatment of varicose veins has yet to be reached. This systematic review aims to establish the optimal compression regimen after venous treatment. Methods A systematic review of MEDLINE, Embase an... Read More about Systematic review of compression following treatment for varicose veins.

Clinical and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the CLASS trial (2015)
Journal Article
Brittenden, J., Cotton, S. C., Elders, A., Tassie, E., Scotland, G., Ramsay, C. R., Norrie, J., Burr, J., Francis, J., Wileman, S., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., MacLennan, G., Prior, M., …Campbell, M. K. (2015). Clinical and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the CLASS trial. Health Technology Assessment, 19(27), 1-342. https://doi.org/10.3310/hta19270

Background
Foam sclerotherapy (foam) and endovenous laser ablation (EVLA) have emerged as alternative treatments to surgery for patients with varicose veins, but uncertainty exists regarding their effectiveness in the medium to longer term.

Objec... Read More about Clinical and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the CLASS trial.

A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins (2015)
Journal Article
Nandhra, S., El-sheikha, J., Carradice, D., Wallace, T., Souroullas, P., Samuel, N., Smith, G., & Chetter, I. C. (2015). A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins. Journal of vascular surgery, 61(3), 741-746. https://doi.org/10.1016/j.jvs.2014.09.037

Background: This randomized clinical trial compared endovenous laser ablation (EVLA) and surgical ligation with attempted stripping in the treatment of small saphenous vein (SSV) insufficiency. The early results demonstrated that EVLA was more likely... Read More about A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins.

The Impact of Chronic Cough: A Cross-Sectional European Survey (2015)
Journal Article
Chamberlain, S. A., Garrod, R., Douiri, A., Masefield, S., Powell, P., Bücher, C., Pandyan, A., Morice, A. H., & Birring, S. S. (2015). The Impact of Chronic Cough: A Cross-Sectional European Survey. Lung, 193(3), 401-408. https://doi.org/10.1007/s00408-015-9701-2

© 2015, Springer Science+Business Media New York. Purpose: Studies that investigate the impact of chronic cough have largely focused on patients attending secondary care. Our aim was to investigate the opinions of the wider general population across... Read More about The Impact of Chronic Cough: A Cross-Sectional European Survey.

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., Holmes, E., Le Roux, C. W., Atkin, S. L., & Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

Compression regimes after endovenous ablation for superficial venous insufficiency – A survey of members of the Vascular Society of Great Britain and Ireland (2015)
Journal Article
El-Sheikha, J., Nandhra, S., Carradice, D., Acey, C., Smith, G., Campbell, B., & Chetter, I. (2016). Compression regimes after endovenous ablation for superficial venous insufficiency – A survey of members of the Vascular Society of Great Britain and Ireland. Phlebology, 31(1), 16-22. https://doi.org/10.1177/0268355514567732

Introduction: The optimal compression regime following ultrasound guided foam sclerotherapy (UGFS), radiofrequency ablation (RFA) and endovenous laser ablation (EVLA) for varicose veins is not known. The aim of this study was to document current prac... Read More about Compression regimes after endovenous ablation for superficial venous insufficiency – A survey of members of the Vascular Society of Great Britain and Ireland.

The value of telehealth in the early detection of chronic obstructive pulmonary disease exacerbations: A prospective observational study (2015)
Journal Article
Hamad, G. A., Crooks, M., & Morice, A. H. (2016). The value of telehealth in the early detection of chronic obstructive pulmonary disease exacerbations: A prospective observational study. Health Informatics Journal, 22(2), 406-413. https://doi.org/10.1177/1460458214564434

© 2014 The Author(s). We aim to establish the value of telemonitoring in the early detection of chronic obstructive pulmonary disease exacerbations. We followed up patients undergoing chronic obstructive pulmonary disease telemonitoring for 4 months.... Read More about The value of telehealth in the early detection of chronic obstructive pulmonary disease exacerbations: A prospective observational study.

Merkel cell carcinoma in East Yorkshire: A case series and literature review of current management (2015)
Journal Article
Jackson, P. C., Wallis, K., Allgar, V., Lind, M. J., & Stanley, P. R. (2015). Merkel cell carcinoma in East Yorkshire: A case series and literature review of current management. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 68(5), 667-672. https://doi.org/10.1016/j.bjps.2014.12.021

© 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Introduction Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine tumour of the skin. The incidence is rising and it is associated with sun exposure and immunos... Read More about Merkel cell carcinoma in East Yorkshire: A case series and literature review of current management.