All Outputs (764)

General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial (2008)
Journal Article
Chetter, I. (2008). General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial. Lancet, 372(9656), 2132-2142. https://doi.org/10.1016/S0140-6736%2808%2961699-2

BackgroundThe effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with th... Read More about General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial.

Nurse-led risk assessment/management clinics reduce predicted cardiac morbidity and mortality in claudicants (2008)
Journal Article
Hatfield, J., Gulati, S., Abdul Rahman, M. N., Coughlin, P. A., & Chetter, I. C. (2008). Nurse-led risk assessment/management clinics reduce predicted cardiac morbidity and mortality in claudicants. Journal of Vascular Nursing, 26(4), 118-122. https://doi.org/10.1016/j.jvn.2008.09.004

Quality of life in patients with lower limb ischemia; revised suggestions for analysis (2008)
Journal Article
Gulati, S., Coughlin, P. A., Hatfield, J., & Chetter, I. C. (2009). Quality of life in patients with lower limb ischemia; revised suggestions for analysis. Journal of vascular surgery, 49(1), 122-126. https://doi.org/10.1016/j.jvs.2008.08.011

Background: Quality of life (QoL) is a crucial outcome measure in patients with lower limb ischemia (LLI). The Short Form 36 (SF36) has been proposed as the gold standard instrument for generic QoL analysis in patients with LLI. The Short Form 8 (SF8... Read More about Quality of life in patients with lower limb ischemia; revised suggestions for analysis.

The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply (2008)
Journal Article
Birring, S. S., Mann, V. M., Matos, S., Yousaf, N., Wood, C., Fleming, T., Evans, D. H., Morice, A. H., & Pavord, I. D. (2008). The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply. European respiratory journal, 32(2), 530-531. https://doi.org/10.1183/09031936.00060808

K. McGuinness and colleagues request further details regarding the validation of the Leicester Cough Monitor (LCM) over 24 h. This was not possible during our study because of limitations in battery life 1. Therefore, we compared automated and manual... Read More about The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Reply.

Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status (2008)
Journal Article
Bournazos, S., Rennie, J., Hart, S. P., Fox, K. A. A., & Dransfield, I. (2008). Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), 1491-1498. https://doi.org/10.1161/ATVBAHA.108.167601

OBJECTIVE: Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the... Read More about Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status.

Early result of a randomized controlled trial of treatment for intermittent claudication (2008)
Presentation / Conference Contribution
Mekako, A., Lee, D., Abdul Rahman, H., McCollum, P., Gulati, S., Mehta, T., & Chetter, I. Early result of a randomized controlled trial of treatment for intermittent claudication

Peak wall stress measurement in elective and acute abdominal aortic aneurysms (2007)
Journal Article
Heng, M. S., Fagan, M. J., Collier, J. W., Desai, G., McCollum, P. T., & Chetter, I. C. (2008). Peak wall stress measurement in elective and acute abdominal aortic aneurysms. Journal of vascular surgery, 47(1), 17-22. https://doi.org/10.1016/j.jvs.2007.09.002

Background: Abdominal aortic aneurysm (AAA) rupture occurs when wall stress exceeds wall strength. Engineering principles suggest that aneurysm diameter is only one aspect of its geometry that influences wall stress. Finite element analysis considers... Read More about Peak wall stress measurement in elective and acute abdominal aortic aneurysms.

A prospective, randomized controlled trial comparing the effects of a fibrin sealant (EVICEL) versus manual compression on hemostatic effectiveness during vascular surgical procedures utilizing polytetrafluoroethylene graft material (2007)
Presentation / Conference Contribution
Chetter, I. A prospective, randomized controlled trial comparing the effects of a fibrin sealant (EVICEL) versus manual compression on hemostatic effectiveness during vascular surgical procedures utilizing polytetrafluoroethylene graft material

Alterations in thyroid status do not affect plasma peptide YY (PYY) and ghrelin concentrations (2007)
Journal Article
Manuchehri, A. M., Sathyapalan, T., Jayagopal, V., Kilpatrick, E. S., Ghatei, M. A., Bloom, S. R., & Atkin, S. L. (2008). Alterations in thyroid status do not affect plasma peptide YY (PYY) and ghrelin concentrations. Clinical Endocrinology, 68(5), 836-838. https://doi.org/10.1111/j.1365-2265.2007.03093.x

Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review (2007)
Journal Article
Mekako, A., & Chetter, I. (2007). Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review. Annals of vascular surgery, 21(5), 637-639. https://doi.org/10.1016/j.avsg.2007.03.013

Endovenous laser therapy (EVLT) for the treatment of varicose veins has been shown to be effective and relatively safe. Reported complications are few and transient. Whereas it is not uncommon to have cutaneous hyperpigmentation following treatment m... Read More about Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review.

Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty (2007)
Journal Article
Ray, B., Chetter, I. C., Lee, H. L. D., Ettelaie, C., & McCollum, P. T. (2007). Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty. British journal of surgery, 94(9), 1092-1095. https://doi.org/10.1002/bjs.5759

Background:In vitro studies suggest an association between raised levels of tissue factor and restenosis after coronary percutaneous transluminal angioplasty (PTA). This prospective, controlled study examined the association between plasma tissue fac... Read More about Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty.

Attitudes to research in surgical training (Winner) (2007)
Presentation / Conference Contribution
Coughlin, P. A., & Chetter, I. Attitudes to research in surgical training (Winner)

Cystic lesions of the pancreas (CLP) are increasingly being recognised due to the wide-spread use of cross-sectional imaging. The vast majority although asymptomatic is associated with malignant potential and proves to be a diagnostic challenge. Ther... Read More about Attitudes to research in surgical training (Winner).

Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4 (2007)
Journal Article
Ramachandran, R., Sadofsky, L., Xiao, Y., Botham, A., Cowen, M., Morice, A., & Compton, S. J. (2007). Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4. American journal of physiology. Lung cellular and molecular physiology, 292(3), L788-L798. https://doi.org/10.1152/ajplung.00226.2006

Human lung fibroblasts express proteinase-activated receptor-1 (PAR 1 ), PAR 2 and PAR 3 , but not PAR 4 . Because PAR 2 has inflammatory effects on human primary bronchial fibroblasts (HPBF), we asked 1) whether the inflammatory mediators TNF-α and... Read More about Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.

Antibiotic prophylaxis in varicose vein surgery: a double-blind randomized controlled clinical trial (2007)
Presentation / Conference Contribution
Mekako, A. I., Coughlin, P. A., Hatfield, J., Baker, R., Dacthler, J., Akomolafe, B., Renwick, P., Johnson, B., McCollum, P. T., & Chetter, I. C. Antibiotic prophylaxis in varicose vein surgery: a double-blind randomized controlled clinical trial

Differential functions of tissue factor in the trans-activation of cellular signalling pathways (2006)
Journal Article
Ettelaie, C., Li, C., Collier, M. E. W., Pradier, A., Frentzou, G. A., Wood, C. G., Chetter, I. C., McCollum, P. T., Bruckdorfer, K. R., & James, N. J. (2007). Differential functions of tissue factor in the trans-activation of cellular signalling pathways. Atherosclerosis, 194(1), 88-101. https://doi.org/10.1016/j.atherosclerosis.2006.10.010

In this study we examined the ability of tissue factor (TF) alone, or in conjunction with factor VIIa, factor Xa and TFPI in activating a number of key signalling pathways associated with cellular growth, stress and differentiation responses in human... Read More about Differential functions of tissue factor in the trans-activation of cellular signalling pathways.

A nonrandomised controlled trial of endovenous laser therapy and surgery in the treatment of varicose veins (2006)
Journal Article
Mekako, A. I., Hatfield, J., Bryce, J., Lee, D., McCollum, P. T., & Chetter, I. (2006). A nonrandomised controlled trial of endovenous laser therapy and surgery in the treatment of varicose veins. Annals of vascular surgery, 20(4), 451-457. https://doi.org/10.1007/s10016-006-9095-y

Endovenous laser therapy (EVLT) is a minimally invasive treatment for varicose veins. This study compares early quality-of-life (QoL) outcomes following EVLT and surgery. Two nonrandomized groups were studied: an EVLT group with 70 patients, median a... Read More about A nonrandomised controlled trial of endovenous laser therapy and surgery in the treatment of varicose veins.

Response to letter to editor re: Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Assessing the validity and responsiveness of disease-specific quality of life instruments in intermittent claudication. Eur J Vasc Eudovasc Surg 2006;31:46-52 (2006)
Journal Article
Mehta, T. A., & Chetter, I. C. (2006). Response to letter to editor re: Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Assessing the validity and responsiveness of disease-specific quality of life instruments in intermittent claudication. Eur J Vasc Eudovasc Surg 2006;31:46-52. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 32(1), 110. https://doi.org/10.1016/j.ejvs.2006.02.005

Combined endovenous laser therapy and ambulatory phlebectomy: refinement of a new technique (2006)
Journal Article
Mekako, A., Hatfield, J., Bryce, J., Lee, D., Heng, M., McCollum, P., & Chetter, I. (2006). Combined endovenous laser therapy and ambulatory phlebectomy: refinement of a new technique. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 32(6), 725-729. https://doi.org/10.1016/j.ejvs.2006.06.002

Objective. Sclerotherapy (IS) or ambulatory phlebectomy (AP) are required as subsequent interventions in majority of cases following endovenous laser therapy (EVLT). We assessed whether AP performed concomitantly with EVLT (EVLTAP), is effective, acc... Read More about Combined endovenous laser therapy and ambulatory phlebectomy: refinement of a new technique.

A hybrid screening programme for clinically significant abdominal aortic aneurysms (2006)
Presentation / Conference Contribution
Heng, M., Venkatasubramaniam, A., Lee, D., Bryce, J., Tennison, C., Berry, B., Chetter, I., & McCollum, P. A hybrid screening programme for clinically significant abdominal aortic aneurysms

Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins (2006)
Journal Article
Chetter, I., Mylankal, K. J., Hughes, H., & Fitridge, R. (2006). Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins. British journal of surgery, 93(2), 169-174. https://doi.org/10.1002/bjs.5261

Background: The aim was to compare early postoperative subjective outcome measures in a randomized trial of multiple stab incision phlebectomy (MSIP) and transilluminated powered phlebectomy (TIPP) for the treatment of varicose veins. Methods: Patien... Read More about Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins.