All Outputs (12)

Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery (2023)
Thesis
Meddick-Dyson, S. (2023). Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4587991

Background Palliative and end-of-life care have important roles in intensive care units (ICUs) given symptom burden and rate of mortality in ICUs. However, we do not know how ICU-based palliative care interventions should be implemented. This system... Read More about Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery.

Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I (2023)
Thesis
Bolanle, O. I. (2023). Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4420724

Despite the plethora of drugs currently available for managing coronary artery disease (CAD) patients with or without type 2 diabetes mellitus (T2DM), yet CAD frequently progresses, necessitating a coronary artery bypass graft (CABG) procedure using... Read More about Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I.

Low-dose methotrexate: not the hepatotoxic medication we once thought (2023)
Thesis
Turner, L. V. B. (2023). Low-dose methotrexate: not the hepatotoxic medication we once thought. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4443697

Methotrexate is a highly efficacious and frequently utilised disease-modifying medication. Concern regarding methotrexate-related hepatotoxicity has impeded the widespread application of the drug, despite a lack of high-quality evidence demonstrating... Read More about Low-dose methotrexate: not the hepatotoxic medication we once thought.

Predicting and preventing relapse of depression in primary care: a mixed methods study (2023)
Thesis
Moriarty, A. S. (2023). Predicting and preventing relapse of depression in primary care: a mixed methods study. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4483741

Background Most people with depression are managed in primary care. Relapse (reemergence of depression symptoms after improvement) is common and contributes to the burden and morbidity associated with depression. There is a lack of evidence-based ap... Read More about Predicting and preventing relapse of depression in primary care: a mixed methods study.

Co-locating universal welfare advice in health settings for mothers and their families (2023)
Thesis
Reece, S. (2023). Co-locating universal welfare advice in health settings for mothers and their families. (Thesis). The University of Hull and the University of York. https://hull-repository.worktribe.com/output/4672312

Childhood deprivation is associated with poor health and social outcomes, limiting childhood development with long-lasting effects into adulthood. Welfare advice services improve financial security but access is often unequal for the most vulnerable.... Read More about Co-locating universal welfare advice in health settings for mothers and their families.

The Host-Microbiota Axis in Chronic Wound Healing (2023)
Thesis
Stafford, A. R. (2023). The Host-Microbiota Axis in Chronic Wound Healing. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4424929

Chronic, non-healing skin wounds represent a substantial area of unmet clinical need, leading to debilitating morbidity and mortality in affected individuals. Due to their high prevalence and recurrence, chronic wounds pose a significant economic bur... Read More about The Host-Microbiota Axis in Chronic Wound Healing.

Addressing delays to treatment in patients with chronic limb-threatening ischaemia (2023)
Thesis
Birmpili, P. (2023). Addressing delays to treatment in patients with chronic limb-threatening ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371299

Patients with CLTI often face long delays from referral to the vascular surgery service and hospital admission to revascularisation, and there is limited evidence on the effect of these delays on patient outcomes. This thesis aims to identify factors... Read More about Addressing delays to treatment in patients with chronic limb-threatening ischaemia.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. (2023). Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory (2023)
Thesis
Wray, A. (2023). Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4609487

Background: In the UK, 46,300 children are bereaved of a parent each year. We understand bereaved people need a supportive response from those around them. However, there is limited evidence to inform our understanding of this. Aim: To explore how c... Read More about Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory.

Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education (2023)
Thesis
Kirkness, K. (2023). Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4407885

It is well established that the goals of education can only be achieved through the constructive alignment of instruction, learning and assessment. There is a gap in research interpreting the lived experiences of stakeholders within the UK learning e... Read More about Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education.

The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos (2023)
Thesis
Martin, F. (2023). The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4430667

Background: Blood-derived products are a growing area of therapeutic treatments for a diverse range of conditions, including hair loss, scarring, muscle injury, wounds, arthritis, and symptoms related to the menopause. Platelet-rich plasma (PRP) is o... Read More about The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos.

Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study (2023)
Thesis
Boam, G. L. (2023). Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4567461

Following surgery, patients with a major lower limb amputation face physical and mental health challenges. For clinicians and physiotherapists to reach a consensus and provide a suitable level of amputation for each patient, the understanding of post... Read More about Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study.