All Outputs (21)

Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty (2024)
Thesis
Randall, J. (2024). Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4659916

Aim Non-anaemic iron deficiency although identified as a potential area for improving patient outcome in the literature, its effect on patient outcomes post-surgery is an under researched topic, with numerous gaps in the published literature. The ai... Read More about Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty.

The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables (2024)
Thesis
Kassianides, X. (2024). The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4659777

Background: Modern intravenous iron preparations (e.g. ferric derisomaltose (FDI), ferric carboxymaltose (FCM)) are commonly used in non-dialysis-dependent chronic kidney disease (CKD) patients. Despite similar efficacy and safety in terms of previou... Read More about The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables.

The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation (2024)
Thesis
Greaves, J. (2024). The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4609527

The proper activation and subsequent differentiation of naive CD4+ T cells into effector T helper and regulatory T cells is vital for directing an appropriate adaptive immune response to specific infections. Recent evidence has identified long non-co... Read More about The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation.

Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis (2024)
Thesis
Muscutt, E. W. (2024). Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4557553

Visceral leishmaniasis (VL) causes immune and haematological dysfunction and is fatal in >95% of cases if left untreated. While macrophages are vital for efficient Leishmania parasite clearance, parasite-macrophage interactions are critical for VL pr... Read More about Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis.

The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease (2024)
Thesis
Nickolay, T. (2024). The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4659878

This thesis investigates the utility of cardiopulmonary exercise testing (CPET) in assessing and managing patients with coronary artery disease (CAD), particularly focusing on the significance of oxygen pulse (O2Pulse) inflections as a marker for myo... Read More about The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease.

Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery (2023)
Thesis
Meddick-Dyson, S. (2023). Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4587991

Background Palliative and end-of-life care have important roles in intensive care units (ICUs) given symptom burden and rate of mortality in ICUs. However, we do not know how ICU-based palliative care interventions should be implemented. This system... Read More about Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery.

Low-dose methotrexate: not the hepatotoxic medication we once thought (2023)
Thesis
Turner, L. V. B. (2023). Low-dose methotrexate: not the hepatotoxic medication we once thought. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4443697

Methotrexate is a highly efficacious and frequently utilised disease-modifying medication. Concern regarding methotrexate-related hepatotoxicity has impeded the widespread application of the drug, despite a lack of high-quality evidence demonstrating... Read More about Low-dose methotrexate: not the hepatotoxic medication we once thought.

Predicting and preventing relapse of depression in primary care: a mixed methods study (2023)
Thesis
Moriarty, A. S. (2023). Predicting and preventing relapse of depression in primary care: a mixed methods study. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4483741

Background Most people with depression are managed in primary care. Relapse (reemergence of depression symptoms after improvement) is common and contributes to the burden and morbidity associated with depression. There is a lack of evidence-based ap... Read More about Predicting and preventing relapse of depression in primary care: a mixed methods study.

Co-locating universal welfare advice in health settings for mothers and their families (2023)
Thesis
Reece, S. (2023). Co-locating universal welfare advice in health settings for mothers and their families. (Thesis). The University of Hull and the University of York. https://hull-repository.worktribe.com/output/4672312

Childhood deprivation is associated with poor health and social outcomes, limiting childhood development with long-lasting effects into adulthood. Welfare advice services improve financial security but access is often unequal for the most vulnerable.... Read More about Co-locating universal welfare advice in health settings for mothers and their families.

Addressing delays to treatment in patients with chronic limb-threatening ischaemia (2023)
Thesis
Birmpili, P. (2023). Addressing delays to treatment in patients with chronic limb-threatening ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371299

Patients with CLTI often face long delays from referral to the vascular surgery service and hospital admission to revascularisation, and there is limited evidence on the effect of these delays on patient outcomes. This thesis aims to identify factors... Read More about Addressing delays to treatment in patients with chronic limb-threatening ischaemia.

The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos (2023)
Thesis
Martin, F. (2023). The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4430667

Background: Blood-derived products are a growing area of therapeutic treatments for a diverse range of conditions, including hair loss, scarring, muscle injury, wounds, arthritis, and symptoms related to the menopause. Platelet-rich plasma (PRP) is o... Read More about The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos.

Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education (2023)
Thesis
Kirkness, K. (2023). Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4407885

It is well established that the goals of education can only be achieved through the constructive alignment of instruction, learning and assessment. There is a gap in research interpreting the lived experiences of stakeholders within the UK learning e... Read More about Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education.

Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study (2023)
Thesis
Boam, G. L. (2023). Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4567461

Following surgery, patients with a major lower limb amputation face physical and mental health challenges. For clinicians and physiotherapists to reach a consensus and provide a suitable level of amputation for each patient, the understanding of post... Read More about Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study.

Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation (2022)
Thesis
Isaac, E. S. (2022). Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4508137

Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide with sufferers of the condition facing significant morbidity and mortality. Ageing alone is identified as the most significant risk factor for developing the arrhythmia. As such... Read More about Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation.

A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation (2022)
Thesis
Crane, H. (2022). A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4312145

Through-knee amputation (TKA) has several theoretical physical advantages over above-knee amputation (AKA), yet AKA remains the preferred level of amputation by UK vascular surgeons when below-knee amputation (BKA) is not feasible. How clinician’s pe... Read More about A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation.

The assessment and management of unintentional weight loss associated with cachexia in a primary care setting: a mixed-methods study (2022)
Thesis
Nwulu, U. U. (2022). The assessment and management of unintentional weight loss associated with cachexia in a primary care setting: a mixed-methods study. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4420753

Introduction: Unintentional weight loss (UWL) is the main symptom of cachexia, a multifactorial syndrome associated with advanced disease. Other symptoms include loss of appetite and muscle weakness. UWL in older adults can be caused by many disease... Read More about The assessment and management of unintentional weight loss associated with cachexia in a primary care setting: a mixed-methods study.

Assessing professionalism for the selection of mental health clinicians: the development and validation of a situational judgement test (2022)
Thesis
Aylott, L. M. E. (2022). Assessing professionalism for the selection of mental health clinicians: the development and validation of a situational judgement test. (Thesis). The University of Hull and The University of York. https://hull-repository.worktribe.com/output/4192760

Patients using mental health services are vulnerable to abuse and exploitation, yet there is no consensus on assessment for values-based recruitment (VBR) in this setting. VBR requires evaluating attitudes, knowledge and traits relevant to the delive... Read More about Assessing professionalism for the selection of mental health clinicians: the development and validation of a situational judgement test.

The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer (2022)
Thesis
Bullock, A. F. (2022). The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4484119

Background: Older adults with cancer are a complex and growing population requiring tailored care to achieve optimum treatment outcomes. However, their care is complicated by underrecognised and under-treated nutrition-related wasting disorders: mal... Read More about The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer.

An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function (2020)
Thesis
Ahmed, Y. (2020). An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function. (Thesis). Hull York Medical School, The University of Hull and The University of York. Retrieved from https://hull-repository.worktribe.com/output/4200904

Atherosclerosis is a major underlying cause in cardiovascular disease and a significant health concern in developed countries. Part of the mechanism by which platelets are linked to this process is via their activation by oxidised Low-Density Lipopro... Read More about An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function.

Post Treatment for Prostate Cancer: The Experiences and Psychosocial Needs of Black African and Black Caribbean Men and their Partners (2019)
Thesis
Bamidele, O. (2019). Post Treatment for Prostate Cancer: The Experiences and Psychosocial Needs of Black African and Black Caribbean Men and their Partners. (Thesis). Ulster University. https://hull-repository.worktribe.com/output/3303524

This study explored the experiences, psychosocial needs and how best to address them after prostate cancer treatment for Black African/Black Caribbean men and their partners in England. Cancer statistics in the United Kingdom show that Black African... Read More about Post Treatment for Prostate Cancer: The Experiences and Psychosocial Needs of Black African and Black Caribbean Men and their Partners.