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Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abebe, M., Abebe, Z., Abil, O. Z., Aboyans, V., Abrham, A. R., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., Accrombessi, M. M. K., …Murray, C. J. L. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1859-1922. https://doi.org/10.1016/S0140-6736%2818%2932335-3

Background
How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services.... Read More about Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017.

Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
Murray, C. J. L., Callender, C. S. K. H., Kulikoff, X. R., Srinivasan, V., Abate, D., Abate, K. H., Abay, S. M., Abbasi, N., Abbastabar, H., Abdela, J., Abdelalim, A., Abdel-Rahman, O., Abdi, A., Abdoli, N., Abdollahpour, I., Abdulkader, R. S., Abebe, H. T., Abebe, M., Abebe, Z., Abebo, T. A., …Lim, S. S. (2018). Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1995-2051. https://doi.org/10.1016/S0140-6736%2818%2932278-5

© 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international in... Read More about Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017.

A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial (2018)
Journal Article
Huang, C., Roberts, Z., Cannings-John, R., Sanders, J., Pickett, K., Montgomery, A., & Robling, M. (2019). A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial. Nicotine and Tobacco Research, 21(12), 1660-1664. https://doi.org/10.1093/ntr/nty232

Reducing smoking in pregnancy was a primary outcome in our Building Blocks trial of the Family Nurse Partnership. We calibrated maternal reports of smoking using cotinine values derived from urine samples to assess tobacco use. This involves identify... Read More about A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial.

Integration of oncology and palliative care: a Lancet Oncology Commission (2018)
Journal Article
Kaasa, S., Loge, J. H., Aapro, M., Albreht, T., Anderson, R., Bruera, E., Brunelli, C., Caraceni, A., Cervantes, A., Currow, D. C., Deliens, L., Fallon, M., Gómez-Batiste, X., Grotmol, K. S., Hannon, B., Haugen, D. F., Higginson, I. J., Hjermstad, M. J., Hui, D., Jordan, K., …Lundeby, T. (2018). Integration of oncology and palliative care: a Lancet Oncology Commission. The lancet oncology, 19(11), e588-e653. https://doi.org/10.1016/S1470-2045%2818%2930415-7

Full integration of oncology and palliative care relies on the specific knowledge and skills of two modes of care: the tumour-directed approach, the main focus of which is on treating the disease; and the host-directed approach, which focuses on the... Read More about Integration of oncology and palliative care: a Lancet Oncology Commission.

Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care (2018)
Journal Article
Allgar, V. L., Chen, H., Richfield, E., Currow, D., Macleod, U., & Johnson, M. J. (2018). Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care. Journal of pain and symptom management, 56(4), 602-612. https://doi.org/10.1016/j.jpainsymman.2018.07.002

Background. The assessment of patients' needs for care is a critical step in achieving patient-centered cancer care. Tools can be used to assess needs and inform care planning. The Needs Assessment Tool:Progressive DiseaseeCancer (NAT:PD-C) is an Aus... Read More about Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care.

Missed opportunity? Worsening breathlessness as a harbinger of death: a cohort study (2018)
Journal Article
Currow, D. C., Smith, J. M., Chansriwong, P., Noble, S. I., Nikolaidou, T., Ferreira, D., Johnson, M. J., & Ekström, M. (2018). Missed opportunity? Worsening breathlessness as a harbinger of death: a cohort study. European respiratory journal, 52(3), Article 1800684. https://doi.org/10.1183/13993003.00684-2018

Introduction: To explore trajectories of breathlessness intensity by function and life-limiting illness diagnosis in the last 3 weeks of life in palliative care patients.

Methods: Prospective, consecutive cohort with point-of-care data of patients o... Read More about Missed opportunity? Worsening breathlessness as a harbinger of death: a cohort study.

A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol (2018)
Journal Article
Thomas-Jones, E., Lloyd, A., Roland, D., Sefton, G., Tume, L., Hood, K., Huang, C., Edwards, D., Oliver, A., Skone, R., Lacy, D., Sinha, I., Preston, J., Mason, B., Jacob, N., Trubey, R., Strange, H., Moriarty, Y., Grant, A., Allen, D., & Powell, C. (2018). A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol. BMC Pediatrics, 18(1), Article 244. https://doi.org/10.1186/s12887-018-1210-z

© 2018 The Author(s). Background: In hospital, staff need to routinely monitor patients to identify those who are seriously ill, so that they receive timely treatment to improve their condition. A Paediatric Early Warning System is a multi-faceted so... Read More about A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol.

High health gain patients with asthma: a cross-sectional study analysing national Scottish data sets (2018)
Journal Article
Mukherjee, M., Nwaru, B. I., Soyiri, I., Grant, I., & Sheikh, A. (2018). High health gain patients with asthma: a cross-sectional study analysing national Scottish data sets. NPJ Primary Care Respiratory Medicine, 28, Article 27. https://doi.org/10.1038/s41533-018-0094-6

Studies have shown that a small proportion of patients have particularly high needs and are responsible for disproportionally high disease burden. Estimates suggest that 2–5% of patients are high users of healthcare for their health gain. Such patien... Read More about High health gain patients with asthma: a cross-sectional study analysing national Scottish data sets.

Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils (2018)
Journal Article
Birkin, E., Moore, K. S., Huang, C., Christopher, M., Rees, J. I., Jayaprakasam, V., & Fielding, P. A. (2018). Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils. Medicine, 97(24), Article e11040. https://doi.org/10.1097/md.0000000000011040

To determine the extent of physiological variation of uptake of 18F-flurodeoxyglucose (FDG) within palatine tonsils. To define normal limits for side-to-side variation and characterize factors affecting tonsillar uptake of FDG.

Over a period of 16... Read More about Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils.

Exogenous sex steroid hormones and asthma in females: protocol for a population-based retrospective cohort study using a UK primary care database (2018)
Journal Article
Nwaru, B. I., Simpson, C. R., Soyiri, I. N., Pillinger, R., Appiagyei, F., Ryan, D., Critchley, H., Price, D. B., Hawrylowicz, C. M., & Sheikh, A. (2018). Exogenous sex steroid hormones and asthma in females: protocol for a population-based retrospective cohort study using a UK primary care database. BMJ open, 8(6), Article e020075. https://doi.org/10.1136/bmjopen-2017-020075

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Female sex steroid hormones have been implicated in sex-related differences in the development... Read More about Exogenous sex steroid hormones and asthma in females: protocol for a population-based retrospective cohort study using a UK primary care database.

Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016 (2018)
Journal Article
Fullman, N., Yearwood, J., Abay, S. M., Abbafati, C., Abd-Allah, F., Abdela, J., Abdelalim, A., Abebe, Z., Abebo, T. A., Aboyans, V., Abraha, H. N., Abreu, D. M. X., Abu-Raddad, L. J., Adane, A. A., Adedoyin, R. A., Adetokunboh, O., Adhikari, T. B., Afarideh, M., Afshin, A., Agarwal, G., …Lozano, R. (2018). Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016. Lancet, 391(10136), 2236-2271. https://doi.org/10.1016/S0140-6736%2818%2930994-2

Copyright © 2018 The Author(s). Published by Elsevier Ltd. Background A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has falt... Read More about Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016.

The future for diagnostic tests of acute kidney injury in critical care: evidence synthesis, care pathway analysis and research prioritisation (2018)
Journal Article
Hall, P. S., Mitchell, E. D., Smith, A. F., Cairns, D. A., Messenger, M., Hutchinson, M., Wright, J., Vinall-Collier, K., Corps, C., Hamilton, P., Meads, D., & Lewington, A. (2018). The future for diagnostic tests of acute kidney injury in critical care: evidence synthesis, care pathway analysis and research prioritisation. Health Technology Assessment, 22(32), 1-274. https://doi.org/10.3310/hta22320

© Queen’s Printer and Controller of HMSO 2018. Background: Acute kidney injury (AKI) is highly prevalent in hospital inpatient populations, leading to significant mortality and morbidity, reduced quality of life and high short- and long-term health-c... Read More about The future for diagnostic tests of acute kidney injury in critical care: evidence synthesis, care pathway analysis and research prioritisation.

Improving predictive asthma algorithms with modelled environment data for Scotland: an observational cohort study protocol (2018)
Journal Article
Soyiri, I. N., Sheikh, A., Reis, S., Kavanagh, K., Vieno, M., Clemens, T., Carnell, E. J., Pan, J., King, A., Beck, R. C., Ward, H. J., Dibben, C., Robertson, C., & Simpson, C. R. (2018). Improving predictive asthma algorithms with modelled environment data for Scotland: an observational cohort study protocol. BMJ open, 8(5), Article e023289. https://doi.org/10.1136/bmjopen-2018-023289

Abstract
Introduction Asthma has a considerable, but potentially, avoidable burden on many populations globally. Scotland has some of the poorest health outcomes from asthma. Although ambient pollution, weather changes and sociodemographic factors ha... Read More about Improving predictive asthma algorithms with modelled environment data for Scotland: an observational cohort study protocol.

Validation of the dyspnea exertion scale of breathlessness in people with life-limiting illness (2018)
Journal Article
Sandberg, J., Johnson, M. J., Currow, D. C., & Ekström, M. (2018). Validation of the dyspnea exertion scale of breathlessness in people with life-limiting illness. Journal of pain and symptom management, 56(3), 430-435.e2. https://doi.org/10.1016/j.jpainsymman.2018.05.002

Background
Although chronic breathlessness is common in life-limiting illnesses, validated feasible instruments to measure functional impact of the symptom in this population are scarce. We aimed to validate the Dyspnea Exertion Scale (DES) compared... Read More about Validation of the dyspnea exertion scale of breathlessness in people with life-limiting illness.

A randomized open-label study of guideline-driven antiemetic therapy versus single agent antiemetic therapy in patients with advanced cancer and nausea not related to anticancer treatment (2018)
Journal Article
Hardy, J., Skerman, H., Glare, P., Philip, J., Hudson, P., Mitchell, G., Martin, P., Spruyt, O., Currow, D., & Yates, P. (2018). A randomized open-label study of guideline-driven antiemetic therapy versus single agent antiemetic therapy in patients with advanced cancer and nausea not related to anticancer treatment. BMC Cancer, 18(1), Article 510. https://doi.org/10.1186/s12885-018-4404-8

© 2018 The Author(s). Background: Nausea/vomiting (N/V) not related to anti-cancer treatment is common in patients with advanced cancer. The standard approach to management is to define a dominant cause, and treat with an antiemetic selected through... Read More about A randomized open-label study of guideline-driven antiemetic therapy versus single agent antiemetic therapy in patients with advanced cancer and nausea not related to anticancer treatment.

Self-reported skin concerns: An epidemiological study of community-dwelling older people (2018)
Journal Article
Cowdell, F., Dyson, J., Long, J., & Macleod, U. (2018). Self-reported skin concerns: An epidemiological study of community-dwelling older people. International journal of older people nursing, 13(3), e12195. https://doi.org/10.1111/opn.12195

Background
Globally the population is getting older and it is essential to develop effective interventions to promote healthy ageing. Skin change with age is inevitable and renders this often neglected organ more vulnerable to damage and breakdown;... Read More about Self-reported skin concerns: An epidemiological study of community-dwelling older people.

Phenotyping patients with chronic cough: Evaluating the ability to predict the response to anti-inflammatory therapy (2018)
Journal Article
Sadeghi, M. H., Wright, C. E., Hart, S., Crooks, M., & Morice, A. (2018). Phenotyping patients with chronic cough: Evaluating the ability to predict the response to anti-inflammatory therapy. Annals of Allergy, Asthma and Immunology, 120(3), 285-291. https://doi.org/10.1016/j.anai.2017.12.004

© 2017 Background: Whether the fraction of exhaled nitric oxide (FeNO) measurement can predict the response to anti-inflammatory treatment in chronic cough is unknown. Objective: To explore whether the effectiveness of treatment with 10 mg of montelu... Read More about Phenotyping patients with chronic cough: Evaluating the ability to predict the response to anti-inflammatory therapy.

Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial (2018)
Journal Article
Gurusamy, K., Corrigan, N., Croft, J., Twiddy, M., Morris, S., Woodward, N., Bandula, S., Hochhauser, D., Napp, V., Pullan, A., Jakowiw, N., Prasad, R., Damink, S. O., van Laarhoven, C. J., de Wilt, J. H., Brown, J., & Davidson, B. R. (2018). Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial. Trials, 19(1), https://doi.org/10.1186/s13063-018-2499-5

Background:Although surgical resection has been considered the only curative option for colorectal livermetastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment. A prospective randomised trial is required to... Read More about Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial.